Zonghui Yuan

TL;DR: This study was the first of its kind to evaluate the microbiological toxicity of tilmicosin using a chemostat model and provides new insight into the co-occurrence of macrolide resistance and virulence in E. faecalis under tilmicOSin selective pressure.

TL;DR: It is demonstrated for the first time that N1-desoxy QdNOs have the potential to be the major toxic metabolites in adrenaloxicity, which may shed new light on the adrenal toxicity of these fascinating compounds and help to provide a basic foundation for the formulation of safety controls for animal products and the design of new Qd NOs with less harmful effects.

TL;DR: This work reveals that CRNG might play a role in preventing the host from being infected by pathogens and viruses and exerting immune regulatory effects in the cytoplasm, which may be involved in prophylaxis of cyadox in piglets.

TL;DR: The results show that M4 could pass through the blood-testis barrier (BTB), and demonstrate that Sertoli cells (SCs) are the main toxic target for MEQ to induce spermatogenesis deficiency, and suggest that SCs, sex hormones and Y chromosome microdeletion genes are involved in reproductive toxicity mediated by MEQ in vivo.

TL;DR: In conclusion, cyadox was not carcinogenic to rats with the liver and kidney as the target organs, and the side chain may be involved in toxicity and carcinogenicity mediated by QdNOs.