Z
Zongyi Wang
Researcher at Shanghai Jiao Tong University
Publications - 7
Citations - 167
Zongyi Wang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Osteosarcoma & Metastasis. The author has an hindex of 4, co-authored 7 publications receiving 84 citations.
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Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma
Gangyang Wang,Mengxiong Sun,Yafei Jiang,Tao Zhang,Wei Sun,Hongsheng Wang,Fei Yin,Zhuoying Wang,Weilin Sang,Jing Xu,Min Mao,Dongqing Zuo,Zifei Zhou,Chongren Wang,Zeze Fu,Zongyi Wang,Zhenfeng Duan,Yingqi Hua,Zhengdong Cai +18 more
TL;DR: Preclinical work indicates that anlotinib acts as a novel inhibitor of VEGFR2 and MET that blocks tumorigenesis in osteosarcoma, which could be translated into future clinical trials.
Journal ArticleDOI
CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma
Zongyi Wang,Fei Yin,Jing Xu,Tao Zhang,Gangyang Wang,Ming Mao,Zhuoying Wang,Wei Sun,Jing Han,Mengkai Yang,Yafei Jiang,Yingqi Hua,Zhengdong Cai +12 more
TL;DR: It is suggested that CYT997 induces apoptosis and autophagy in OS cells by triggering mutually enhanced ER stress and ROS and may thus be a promising agent against OS.
Journal ArticleDOI
Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo.
Min Mao,Tao Zhang,Zhuoying Wang,Hongsheng Wang,Jing Xu,Fei Yin,Gangyang Wang,Mengxiong Sun,Zongyi Wang,Yingqi Hua,Zhengdong Cai +10 more
TL;DR: It is demonstrated that GLA could exhibit potent anticancer effects through effectively blocking the STAT3 signaling pathway, which was induced by ROS-mediated oxidative stress in OS in vitro and in vivo.
Journal ArticleDOI
Reduction-responsive polypeptide nanomedicines significantly inhibit progression of orthotopic osteosarcoma.
Fei Yin,Zongyi Wang,Yafei Jiang,Tao Zhang,Zhuoying Wang,Yingqi Hua,Zhiming Song,Jianhua Liu,Weiguo Xu,Jing Xu,Zhengdong Cai,Jianxun Ding +11 more
TL;DR: The selective accumulation of micelles, especially P9M/DOX, in tumors induced stronger antitumor effects on both primary and lung metastatic OSs with less systematic toxicity.
Journal ArticleDOI
MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma.
Mengkai Yang,Tao Zhang,Yangfeng Zhang,Xiaojun Ma,Jing Han,Ke Zeng,Yafei Jiang,Zongyi Wang,Zhuoying Wang,Jing Xu,Yingqi Hua,Zhengdong Cai,Wei Sun +12 more
TL;DR: In this paper, the expression of myosin light chain kinase family members between metastasis and non-metastasis patients in the TARGET database was investigated and it was found that only myosIN light chain Kinase family member 4 (MYLK4) had higher expression in metastatic osteosarcoma patients.