Z
Zygmunt Kazimierczuk
Researcher at Warsaw University of Life Sciences
Publications - 131
Citations - 3305
Zygmunt Kazimierczuk is an academic researcher from Warsaw University of Life Sciences. The author has contributed to research in topics: Glycosylation & Benzimidazole. The author has an hindex of 27, co-authored 130 publications receiving 3114 citations. Previous affiliations of Zygmunt Kazimierczuk include Polish Academy of Sciences & University of Osnabrück.
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Journal ArticleDOI
Synthesis of 2'-deoxytubercidin, 2'-deoxyadenosine, and related 2'-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure
Journal ArticleDOI
The selectivity of inhibitors of protein kinase CK2: an update.
Mario A. Pagano,Jenny Bain,Zygmunt Kazimierczuk,Stefania Sarno,Maria Ruzzene,Giovanni Di Maira,Matthew Elliott,Andrzej Orzeszko,Giorgio Cozza,Flavio Meggio,Lorenzo A. Pinna +10 more
TL;DR: DMAT and its parent compound TBI are potent inhibitors of several other kinases, with special reference to PIM (provirus integration site for Moloney murine leukaemia virus), and TBB is significantly more selective toward CK2, although it also inhibits PIM1 and PIM3.
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2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2
Mario A. Pagano,Flavio Meggio,Maria Ruzzene,Mariola Andrzejewska,Zygmunt Kazimierczuk,Lorenzo A. Pinna +5 more
TL;DR: A novel compound, 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT), is described, which is superior to the commonly used specific CK2 inhibitor 4, 5, 6, 7-t Petrabromobenzotriazoles (TBB) in several respects and is the first choice CK2 inhibitors for in vivo studies available to date.
Journal ArticleDOI
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Mario A. Pagano,Mariola Andrzejewska,Maria Ruzzene,Stefania Sarno,Luca Cesaro,Jenny Bain,Matthew Elliott,Flavio Meggio,Zygmunt Kazimierczuk,Lorenzo A. Pinna +9 more
TL;DR: It is proposed to adopt 2c as first choice CK2 inhibitor instead of TBB, especially for in cell studies, because 2c is even more susceptible than TBB to mutations of the unique hydrophobic residues V66 and/or I174 to alanine.
Journal ArticleDOI
Syn-anti conformational analysis of regular and modified nucleosides by 1D 1H NOE difference spectroscopy: a simple graphical method based on conformationally rigid molecules
Helmut Rosemeyer,Gábor Tóth,Bozenna Golankiewicz,Zygmunt Kazimierczuk,Werner Bourgeois,Uwe Kretschmer,Heinz Peter Muth,Frank Seela +7 more
TL;DR: In this paper, the 1D 1 H NOE difference spectra of 50 base and/or sugar-modified nucleosides were measured in (CD 3 ) 2 SO with irradiation of various protons.