American Association for the Advancement of Science

About: American Association for the Advancement of Science is a nonprofit organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Science education & Government. The organization has 353 authors who have published 897 publications receiving 18841 citations. The organization is also known as: AAAS.

2006: signaling breakthroughs of the year.

Abstract: With nominations from leading scientists studying cell signaling, the STKE editors compile a list of the year's most important advances. Signaling breakthroughs included molecules and processes both outside cells and inside cells, from channels in the membrane to chromatin in the nucleus. The nominated research ranged from structural and functional revelations to approaches for the global analysis of signaling pathways. Receptors were highlighted with unexpected proteins functioning as receptors, as well as surprising functions for known receptors. This year also brought new insights into the impact of cell signaling on human physiology and disease.

Focus issue: memories of signals past--plastic changes in nervous system function.

Abstract: Plasticity encompasses the ability of the nervous system to adapt to injury and the ability of the developing and mature brain to change in response to experience. This week's Special Issue of Science focuses on systems-level approaches to understanding cortical plasticity, especially during development. The accompanying Focus Issue of Science's STKE features articles and resources that address issues related to the molecular changes that underlie synaptic plasticity in response to physiological or pathological stimuli.

Science Signaling Podcast: 1 May 2012

Abstract: This Podcast features a conversation with an author of a Research Article published in the 1 May 2012 issue of Science Signaling . Hiroshi Suga discusses the evolution of tyrosine kinases during the transition from unicellularity to multicellularity in the animal lineage. Suga and colleagues analyzed the tyrosine kinase complement of filastereans, which are unicellular organisms that are the closest relatives to the clade that includes the multicellular animals (metazoa) and the choanoflagellates, a group of free-living unicellular and colonial eukaryotes. They found that filastereans share the same basic repertoire of cytoplasmic tyrosine kinases with metazoans and choanoflagellates, but that the receptor tyrosine kinase repertoire of each group differed, implying that this class of tyrosine kinases underwent diversification in each of the lineages. These findings imply that ancestral unicellular eukaryotes used a limited set of receptor tyrosine kinases to receive information from the environment and that these receptors were recruited for use in cell-cell communication and underwent subsequent amplification and diversification in the metazoan lineage.

Discovering “What's Innovative”: The Challenge of Evaluating Education Research and Development Efforts

Abstract: National Science Foundation's (NSF's) MSP Program seeks foremost “to improve student outcomes in high-quality mathematics and science by all students, at all pre-K-12 levels” (NSF-02-061; NSF, 2001...

Focus Issue: Signaling in Neuronal Development, Function, and Disease

Abstract: Behavior and learning require that neurons coordinate communication between regions within the brain and between the brain and peripheral tissues to respond and adapt to the environment. Abnormalities in neuronal function can lead to cognitive, motor, or behavioral disorders during development or aging. Content published in Science Signaling explores the molecular mechanisms that regulate neuronal development and function and that are altered in neurological dysfunction and neurodegenerative disease.