Institution
American Association for the Advancement of Science
Nonprofit•Washington D.C., District of Columbia, United States•
About: American Association for the Advancement of Science is a nonprofit organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Science education & Government. The organization has 353 authors who have published 897 publications receiving 18841 citations. The organization is also known as: AAAS.
Topics: Science education, Government, Public policy, Cancer, Higher education
Papers published on a yearly basis
Papers
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TL;DR: By solving the crystal structure of NDP52 in complex with galectin-8, Li et al. revealed how NDP52 stimulates selective autophagy in response to infection by Salmonella.
Abstract: This Podcast features an interview with Felix Randow, senior author of a Research Article that appears in the 5 February 2013 issue of Science Signaling . Intracellular pathogens such as Salmonella damage vesicular membranes in infected cells. The cargo receptor NDP52 drives selective autophagy of Salmonella and the damaged vesicles with which it is associated. NDP52 detects Salmonella infection by binding to galectin-8, a host protein that is recruited to membranes damaged by the pathogen. By solving the crystal structure of NDP52 in complex with galectin-8, Li et al . revealed how NDP52 stimulates selective autophagy in response to infection by Salmonella .
TL;DR: The transcriptional coactivator Yap promotes migration of cardiomyocytes to the site of injury during heart regeneration and suggests that inhibiting Hippo signaling might be beneficial for promoting healing in damaged hearts.
Abstract: This Podcast features an interview with James Martin, primary author of a Research Article that appears in the 5 May 2015 issue of Science Signaling , about how reducing Hippo signaling might improve the ability of the heart to regenerate. The kinase Hippo prevents overgrowth of the heart during embryonic development by suppressing activity of the transcriptional coactivator Yap, which promotes expression of genes required for cell proliferation. Although Hippo signaling is important during development to keep the heart from growing too much, it limits the ability of the heart to regenerate in mature animals. Morikawa et al . found that, in addition to promoting the expression of genes that drive cell proliferation, Yap also promoted the expression of genes important for cytoskeletal remodeling in cardiomyocytes. Compared to cardiomyocytes from control animals, cardiomyocytes from mice lacking Hippo signaling exhibited enhanced migratory properties in vitro and migrated toward sites of injury in vivo. These findings suggest that inhibiting Hippo signaling might be beneficial for promoting healing in damaged hearts.
TL;DR: This Podcast features an interview with Vitezslav Bryja, Hendrik Korswagen, and Reinoud de Groot about a Research Article that appears in the 18 March 2014 issue of Science Signaling about Huawei1 ubiquitylates Dishevelled to negatively regulate Wnt signaling.
Abstract: This Podcast features an interview with Vitezslav Bryja, Hendrik Korswagen, and Reinoud de Groot about a Research Article that appears in the 18 March 2014 issue of Science Signaling
TL;DR: Sophie Ugolini and Eric Vivier discuss their team’s finding that signaling through inhibitory NK cell receptors determines the distribution of activating receptors, which, in turn, determines the responsiveness of the cells to activating stimuli.
Abstract: This Podcast features a conversation with the senior authors of a Research Article published in the April 5 issue of Science Signaling . Sophie Ugolini and Eric Vivier discuss their team’s finding that signaling through inhibitory NK cell receptors determines the distribution of activating receptors, which, in turn, determines the responsiveness of the cells to activating stimuli. This finding suggests that inhibitory receptors can affect membrane receptor organization and hence the responsiveness of NK cells.
TL;DR: This Podcast features an interview with José María González-Granado, Francisco Sánchez-Madrid, and Vicente Andrés, authors of a Research Article that appears in the 22 April 2014 issue of Science Signaling about a component of the nuclear skeleton that promotes T cell activation.
Abstract: This Podcast features an interview with Jose Maria Gonzalez-Granado, Francisco Sanchez-Madrid, and Vicente Andres, authors of a Research Article that appears in the 22 April 2014 issue of Science Signaling , about a component of the nuclear skeleton that promotes T cell activation. Immunological synapses are macromolecular structures that form at sites of contact between T cells and antigen presenting cells. Reorganization of the actin cytoskeleton is important for formation of immunological synapses, optimal signaling through the T cell receptor, and T cell activation. Gonzalez-Granado et al . found that the abundance of lamin-A, a component of the nuclear lamina, increased during T cell activation. The connection of lamin-A to the cytoskeleton was required for proper cytoskeletal organization at the immunological synapse and for optimal signaling through the T cell receptor.
Authors
Showing all 359 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Kendall N. Houk | 112 | 997 | 54877 |
| M. Cooke | 110 | 915 | 52792 |
| Federica Sallusto | 107 | 244 | 66684 |
| Peter Agre | 104 | 248 | 39051 |
| Michael B. Yaffe | 102 | 379 | 41663 |
| Abul K. Abbas | 88 | 251 | 34965 |
| Jose M. F. Moura | 80 | 647 | 25819 |
| Marcia C. Linn | 72 | 337 | 25744 |
| Eli Y. Adashi | 66 | 442 | 17139 |
| William H. Press | 63 | 180 | 102433 |
| Richard A. Berk | 58 | 293 | 15288 |
| James L. Salzer | 56 | 111 | 11437 |
| Robert E. Kopp | 56 | 199 | 10227 |
| Herbert C. Kelman | 52 | 155 | 12853 |
| Gerard Gilfoyle | 50 | 255 | 8716 |