American Association for the Advancement of Science

About: American Association for the Advancement of Science is a nonprofit organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Science education & Government. The organization has 353 authors who have published 897 publications receiving 18841 citations. The organization is also known as: AAAS.

Science Signaling Podcast: 19 March 2013

Abstract: This Podcast features an interview with Ching-Shih Chen, senior author of a Research Article that appears in the 19 March 2013 issue of Science Signaling . Huang et al . report that the α and γ forms of tocopherol, which is a lipophilic molecule and dietary form of vitamin E, promoted dephosphorylation of the growth-promoting kinase Akt. Tocopherols bound to both Akt and the phosphatase PHLPP1 and recruited them to the plasma membrane, where PHLPP1 dephosphorylated Akt on Ser 473 , thus inactivating Akt. This reduced the proliferation of cultured prostate cancer cells and reduced the growth of prostate tumors xenografted into mice. The authors developed a synthetic derivative of γ-tocopherol that exhibited greater potency than natural tocopherols in this context, suggesting that the development of drugs structurally related to tocopherols might benefit the treatment of prostate and other cancers that are driven by Akt activity.

Science Signaling Podcast: 24 March 2009

Abstract: This is a conversation with Stephen Smerdon, senior author of a Research Article published in the 24 March issue of Science Signaling He discusses his group9s recent characterization of the mechanism for regulating the activity of a bacterial forkhead-associated (FHA) domain

Science Signaling Podcast: 27 October 2009

Abstract: This is a conversation with Myriam Gorospe about a Research Article published in the 27 October 2009 issue of Science Signaling.

Science Signaling Podcast: 23 October 2012

Abstract: This Podcast features an interview with Stephen Nimer, senior author of a Research Article published in the 23 October 2012 issue of Science Signaling . Nimer discusses his group’s finding that Akt signaling stimulates expression of the Ink4a-Arf locus, which encodes the cell cycle regulator p16 and the tumor suppressor p19. The kinase Akt, which is activated by growth signals and is often activated in cancer cells, phophorylated the transcriptional silencer Bmi1 to cause it to dissociate from the Ink4a-Arf locus. The resulting increase in abundance of p16 and p19 led to decreased cell proliferation, tumor growth, and self-renewal of stem and progenitor cells. Therefore, in addition to mediating growth signaling, Akt can also initiate a feedback loop that counteracts growth signaling.