Showing papers by "Autonomous University of Barcelona published in 1974"
145 citations
54 citations
TL;DR: The reactivity of 5-5′-dithiobis(2-nitrobenzoic acid) with thiol groups of calf thymus histone F3 was studied by using the tripeptide glutathione and 2-mercaptoethanol as models, suggesting that the reaction is dependent on the nucleophile-S− concentration.
Abstract: The reactivity of 5-5′-dithiobis(2-nitrobenzoic acid) with thiol groups of calf thymus histone F3 was studied by using the tripeptide glutathione and 2-mercaptoethanol as models. The results found for glutathione suggest that the reaction is dependent on the nucleophile-S− concentration. The reactivity of thiol groups of the histone in 2.4 mM sodium phosphate solutions at room temperature was found to be much higher than for glutathione and almost independent of pH between pH 5 to 7. The reaction follows second order kinetics, K2(app.) at pH 5 being 4000 times higher than K2 for glutathione. The pKa(app.) for thiol groups of histone F3 was estimated to be 4.2 indicating the predominance at low pH of ionic forms of the thiol groups. At 24 mM sodium phosphate, pH 6.6, 80% of thiol groups react at a similar high rate as in the case of 2.4 mM sodium phosphate, and the remaining 20% reacts very slowly, the kinetics being of first order. Local denaturation is not obtained by urea treatment and high temperatures (85°C), but guanidine hydrochloride completely unfolds the microenvironments containing cysteine. It is proposed that such reacting microenvironments are important in the biological role of the histone F3.
41 citations
TL;DR: Three major patterns of oxalate metabolism were found and in the third group an increasedOxalate absorption rate was the main alteration.
38 citations
01 Jan 1974
TL;DR: Ressenya de l'obra de Max Weber apareguda el 1972, Ensayos de sociologia contemporanea as mentioned in this paper, Barcelona: Ediciones Martinez Roca.
Abstract: Ressenya de l'obra de Max Weber apareguda el 1972, Ensayos de sociologia contemporanea. Barcelona: Ediciones Martinez Roca.
33 citations
TL;DR: It is concluded that hydrophobic triplets 1-2-5 and 1-4-5 are required for stabilizing the helices.
25 citations
TL;DR: From simple quark model and duality arguments, the mixing angle is predicted to be θ = arctan ( − 1 2 √2) ≈ −19.5°.
17 citations
TL;DR: There are clinical phramacology programs in three Spanish medical centers but none have developed from pharmacology departments, and ioint appointments with clinical departments do not exist at this early stage in the development of clinical pharmacology.
Abstract: There are clinical phramacology programs in three Spanish medical centers. All have developed from pharmacology departments, and ioint appointments with clinical departments do not exist at this early stage in the development of clinical pharmacology. Recent legislation exerting increased regulatory control over drug products (specialties) has been exacted, but the challenges facing clinical pharmacology in evaluating and selecting useful and safe therapeutic agents from the myriad of new and existing preparations remains immense.
10 citations
TL;DR: In this paper, two kinds of boundary conditions are applied: prescribed temperature history and prescribed heat flux across the surface, and the results are compared with exact ones, when available, or with those obtained from other variational principles like Biot's and Vujanovic's.
Abstract: Lebon-Lambermont's variational principle is used to solve some problems of unsteady heat conduction in semi-infinite solids. These are characterized by temperature dependent heat conductivity and heat capacity. Two kinds of boundary conditions are applied: prescribed temperature history and prescribed heat flux across the surface. This latter problem is investigated by means of the technique proposed by Lardner and Rafalski-Zyskowsky. The results are compared with exact ones, when available, or with those obtained from other variational principles like Biot's and Vujanovic's. In all cases, agreement is very satisfactory.
8 citations
TL;DR: The asymmetrical arterial abnormalities seen in the investigations done before arteriography could mistakenly have suggested stenosis of the main renal artery or of its first branches make one think of an unilateral nephropathy.
6 citations
TL;DR: In this study of the effects of noradrenaline and adrenaline in the isolated rat vas deferens, pD2 and slope of cumulative and non-cumulative curves coincided completely and it is suggested that this may also happen when other rapid-responding agonist preparation systems are used.
01 Jan 1974
TL;DR: A survey of the drugs presented in this compendium of fixed-ratio drug combinations found that some of them are among the most commonly prescribed drugs in the United States.
Abstract: July, 1974 325 LTHOUGH the existence and wide usage of fixed-ratio drug combinations is often mentioned as a matter of concern, data about them are somewhat scant. It is well known that some fixed-ratio drug combinations are among the most commonly prescribed drugs in the United States,1’2 but only a few reports are available concerning the prevalence of these compounds in prescription drugs. The Physicians’ Desk Reference (PDR)3’4 has been shown to be the main source of prescribing information for American doctors for some years,5 and, therefore, it seemed of interest to conduct a survey of the drugs presented in this compendium.