Beaumont Health

About: Beaumont Health is a nonprofit organization based out in Royal Oak, Michigan, United States. It is known for research contribution in the topics: Medicine & Population. The organization has 1483 authors who have published 1448 publications receiving 15407 citations. The organization is also known as: William Beaumont Health System & Beaumont Hospitals.

Renal cell carcinoma metastasis to the thyroid: how long is long enough?

Abstract: Eribulin has been approved as treatment for patients with metastatic breast cancer, who have received at least two chemotherapeutic regimens including an anthracyclineand a taxane-based. When comparing the effects seen in the EMBRACE study with our results, very similar effects are found, with a medium progression-free survival time of 3.7 months in the EMBRACE study and 3.4 months in our sample. Concerning the clinical benefi t rate we even observed a slightly higher rate of 50% compared to the 23% reported in the EMBRACE trial. Adverse events occurred in 99% of the patients in the EMBRACE study compared to 87.5% in our sample. The most common adverse event in the EMBRACE study as well as in our study was fatigue. In the EMBRACE study the most common grade 3 and 4 adverse event was neutropenia. We also found neutropenia to have one of the highest incidences of grade 3 and 4 adverse events along with fatigue and peripheral neuropathy. Unfortunately, no registration of the preexisting neuropathy from previous treatment with other taxane-based chemotherapy regimens was performed. In conclusion we saw a side effect profi le very consistent to what we expected from prior studies. With the effect and side effect profi le of eribulin seen in this study, which is quite comparable to what is found in previous trials, it is worthwhile considering eribulin as a new standard of care. Additional considerations about when to introduce eribulin and who will benefi t the most from it need to be made.

Exercise Training in "At-Risk" Black and White Women: A Comparative Cohort Analyses.

Abstract: PURPOSE Few data on the effect of exercise interventions in black women at risk for cardiovascular disease are available. METHODS Women ≥18 yr of age without known cardiovascular disease with ≥1 coronary risk factor were enrolled in a community-based exercise program ≥3 d·wk for ≥30 min per session for 6 months. Exercise training intensity ~50% to 80% of functional capacity, using heart rate (HR) and/or rating of perceived exertion (RPE) as the primary intensity modulators. Preconditioning versus postconditioning quality of life assessments (depression and level of daytime sleepiness), dietary fat intake, Duke Activity Status Index score, changes in cardiovascular efficiency (systolic/diastolic blood pressure (SBP/DBP), HR, RPE during a standardized submaximal workload), and anthropometric measures, including body weight, body mass index, and waist circumference, were evaluated. RESULTS Of 556 volunteers, 143 were excluded, leaving 413 women (222 white, 191 black; mean ± SD age, 61 ± 9 yr) who met compliance criteria. Both groups demonstrated significant (P < 0.05) postconditioning decreases in body mass index, waist circumference, resting SBP/DBP, and total and LDL cholesterol, and reductions in HR, SBP/DBP, and RPE at a fixed submaximal workload, and in fat screener, depression, and sleep scores. Duke Activity Status Index scores increased significantly (P < 0.0001) for both groups, signifying increases in self-reported functional capacity. Although 87 women (21%) experienced a musculoskeletal injury/discomfort during the program, there were no exercise-related cardiovascular events. CONCLUSIONS A progressive moderate-to-vigorous exercise intervention without preliminary exercise testing elicited comparable improvements in coronary risk factors, anthropometric and quality of life measures, and cardiovascular efficiency in "at-risk" black and white women. These adaptations were achieved at exercise levels below those recommended in contemporary physical activity guidelines.