Beaumont Health

About: Beaumont Health is a nonprofit organization based out in Royal Oak, Michigan, United States. It is known for research contribution in the topics: Medicine & Population. The organization has 1483 authors who have published 1448 publications receiving 15407 citations. The organization is also known as: William Beaumont Health System & Beaumont Hospitals.

Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo.

Abstract: Purpose To test the hypothesis that mitochondrial respiration contributes to local changes in hydration involved in phototransduction-driven expansion of outer retina, as measured by structural responses on optical coherence tomography (OCT) and diffusion magnetic resonance imaging (MRI). Methods Oxygen consumption rate and mitochondrial reserve capacity of freshly isolated C57BL/6 and 129S6/SvEvTac mouse retina were measured using a Seahorse Extracellular Flux Analyzer. Light-stimulated outer retina layer water content was determined by proton density MRI, structure and thickness by ultrahigh-resolution OCT, and water mobility by diffusion MRI. Results Compared with C57BL/6 mice, 129S6/SvEvTac retina demonstrated a less robust mitochondrial respiratory basal level, with a higher reserve capacity and lower oxygen consumption in the light, suggesting a relatively lower production of water. C57BL/6 mice showed a light-triggered surge in water content of outer retina in vivo as well as an increase in hyporeflective bands, thickness, and water mobility. In contrast, light did not evoke augmented hydration in this region or an increase in hyporeflective bands or water mobility in the 129S6/SvEvTac outer retina. Nonetheless, we observed a significant but small increase in outer retinal thickness. Conclusions These studies suggest that respiratory-controlled hydration in healthy retina is linked with a localized light-evoked expansion of the posterior retina in vivo and may serve as a useful biomarker of the function of photoreceptor/retinal pigment epithelium complex.

Biomechanical Evaluation of the TightRope Versus Traditional Docking Ulnar Collateral Ligament Reconstruction Technique Kinematic and Failure Testing

Abstract: Background:Numerous variations of ulnar collateral ligament (UCL) reconstruction have been described since the original technique by Jobe et al.Purpose/Hypothesis:To biomechanically compare the new TightRope technique and the traditional ulnar bone tunnels as used in the docking technique. The hypothesis was that the TightRope technique would exhibit improved kinematics and comparable failure properties.Study Design:Controlled laboratory study.Methods:Seven matched pairs of cadaveric arms (mean age, 44.71 years) were tested in both the native state and reconstructed state. Kinematics were assessed at 15° to 90° of flexion by applying a 1.5-N·m valgus torque and measuring the resultant angular displacement. Failure testing was performed by loading to failure at 4.5 deg/s in 70° of flexion. Sides of a matched pair were randomized to the TightRope (TR) and docking (DO) techniques after testing the native state.Results:There was no significant difference in kinematic results between the native state and recon...

Qualitative and Quantitative Coronary Angiography

Abstract: In patients with coronary artery disease (CAD), cardiac catheterization remains the gold standard in evaluating the degree of luminal narrowing and assessing the appropriateness of a patient’s medical regimen, the need for percutaneous coronary intervention (PCI), or coronary artery bypass grafting (CABG).