Beaumont Health

About: Beaumont Health is a nonprofit organization based out in Royal Oak, Michigan, United States. It is known for research contribution in the topics: Medicine & Population. The organization has 1483 authors who have published 1448 publications receiving 15407 citations. The organization is also known as: William Beaumont Health System & Beaumont Hospitals.

Epidemiology, Clinical Characteristics, and Outcomes of a Large Cohort of COVID-19 Outpatients in Michigan

Abstract: Background: Most outpatients with coronavirus disease 2019 (COVID-19) do not initially demonstrate severe features requiring hospitalization. Understanding this population's epidemiological and clinical characteristics to allow outcome anticipation is crucial in healthcare resource allocation. Methods: Retrospective, multicenter (8 hospitals) study reporting on 821 patients diagnosed with COVID-19 by real-time reverse transcriptase-polymerase chain reaction assay of nasopharyngeal swabs and discharged home to self-isolate after evaluation in emergency departments (EDs) within Beaumont Health System in March, 2020. Outcomes were collected through April 14, 2020, with a minimum of 12 day follow-up and included subsequent ED visit, admission status, and mortality. Results: Of the 821 patients, mean age was 49.3 years (SD 15.7), 46.8% were male and 55.1% were African-American. Cough was the most frequent symptom in 78.2% of patients with a median duration of 3 days (IQR 2-7), and other symptoms included fever 62.1%, rhinorrhea or nasal congestion 35.1% and dyspnea 31.2%. ACEI/ARBs usage was reported in 28.7% patients and 34.0% had diabetes mellitus. Return to the ED for re-evaluation was reported in 19.2% of patients from whom 54.4% were admitted. The patients eventually admitted to the hospital were older (mean age 54.4 vs 48.7 years, p=0.002), had higher BMI (35.4 kg/m2 vs 31.9 kg/m2, p=0.004), were more likely male (58.1% vs 45.4%, p=0.026), and more likely to have hypertension (52.3% vs 29.4%, p<0.001), diabetes mellitus (74.4% vs 29.3%, p<0.001) or prediabetes (25.6% vs 8.4%, p<0.001), COPD (39.5% vs 5.4%, p<0.001), and OSA (36% vs 19%, p<0.001). The overall mortality rate was 1.3%. Conclusion: We found that 80.8% of patients did not return to the ED for re-evaluation. Sending patients with COVID-19 home if they experience mild symptoms is a safe approach for most patients and might mitigate some of the financial and staffing pressures on healthcare systems.

A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response to Mycobacterium tuberculosis and Co-Infection with HIV

Abstract: Mycobacterium tuberculosis (Mtb) is a highly infectious acid-fast bacillus and is known to cause tuberculosis (TB) in humans. It is a leading cause of death from a sole infectious agent, with an estimated 1.5 million deaths yearly worldwide, and up to one third of the world’s population has been infected with TB. The virulence and susceptibility of Mtb are further amplified in the presence of Human Immunodeficiency Virus (HIV). Coinfection with Mtb and HIV forms a lethal combination. Previous studies had demonstrated the synergistic effects of Mtb and HIV, with one disease accelerating the disease progression of the other through multiple mechanisms, including the modulation of the immune response to these two pathogens. The response of the endosomal pattern recognition receptors to these two pathogens, specifically toll-like receptors (TLR)-3, -7, and -9, has not been elucidated, with some studies producing mixed results. This article seeks to review the roles of TLR-3, -7, and -9 in response to Mtb infection, as well as Mtb-HIV-coinfection via Toll-interleukin 1 receptor (TIR) domain-containing adaptor inducing INF-β (TRIF)-dependent and myeloid differentiation factor 88 (MyD88)-dependent pathways.

Insertion-related pain with intramedullary nailing

Abstract: The use of intramedullary nails for the treatment of long bone fractures has become increasingly frequent over the last decade with gradually expanding indications and technological advances. Improved biomechanics relative to plates and less direct fracture exposure are some of the potential benefits of intramedullary nails. However, persistent insertion-related pain is common and may limit satisfactory long term outcomes. The etiologies of this phenomenon remain unclear. Proposed theories for which there is a growing body of supporting evidence include hardware prominence, suboptimal nail entry points leading to soft tissue irritation and structural compromise, local heterotrophic ossification, implant instability with persistent fracture micromotion, and poorly defined insertional strain. Many factors that lead to insertion-related pain are iatrogenic, and careful attention to detail and refined surgical techniques will optimize outcomes.

Three-dimensional preoperative planning accurately guides surgeons for intraoperative implant selection in shoulder arthroplasty

Abstract: Background With the rapid growth of shoulder arthroplasty (SA) over the past decade, the focus has been on improving outcomes and minimizing complications. As a result, preoperative planning tools have become a trend among orthopedic surgeons for SA to aid in achieving optimal implant selection and ultimately continual improvement of outcomes. Success in achieving these goals is predicated on software precision and reliability. Therefore, the purpose of our study was to assess the accuracy of three dimensional (3D) preoperative planning software in guiding orthopaedic surgeons for implant selection in SA. Methods This was a retrospective study of 76 patients who underwent SA all with the same manufacturer's implants by a single fellowship-trained shoulder surgeon. All patients had preoperative CT scans and completed 3D preoperative plans. The final implant selection was decided intraoperatively solely under surgeon's discretion based on review of preoperative plan, intraoperative bone quality, and soft tissue balancing, not restricted by the preoperative plan. Software accuracy was assessed by directly comparing each component size planned to the actual implant selected in the procedure for both humeral and glenoid components. Statistical analyses was performed including paired-sample t tests and rate for perfect matching. Results Our results demonstrated glenoid implant size matched perfectly in 75% of cases and 100% within 1 size in anatomic total shoulder arthroplasty (TSA). Humeral head diameter matched perfectly in 31% of cases and 100% within 1 size. Humeral head thickness matched perfectly in 69% of cases and 100% within 1 size. For reverse shoulder arthroplasty, glenoid baseplate diameter matched perfectly in 81% of the cases and 100% within 1 size. Glenosphere diameter matched perfectly in 88% of the cases and 98% within 1 size. Humeral stem size in both groups were more variable than the remaining components. Conclusion Our study demonstrates that 3D preoperative planning was accurate to guide intraoperative implant selection for both anatomic and reverse SA including both glenoid and humeral components within 1 size. This tool may decrease the need for extensive inventory and instrumentation by improving operating room workflow and surgeon efficiency and may ultimately be translate into better postoperative outcomes. Level of evidence Level IV; Case Series