Central University of Kashmir

About: Central University of Kashmir is a education organization based out in Gāndarbal, Jammu and Kashmir, India. It is known for research contribution in the topics: Higher education & Tourism. The organization has 140 authors who have published 217 publications receiving 1045 citations. The organization is also known as: Central University of Jammu and Kashmir.

Customer experience and engagement in tourism destinations: the experiential marketing perspective

Abstract: Tourism destinations are increasingly offering experiential services to promote the development of their competitive advantage. This research investigates the effects of customers’ tourism engageme...

Tumor microenvironment promotes breast cancer chemoresistance.

Abstract: Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis and therapeutics have momentously improved, chemoresistance remains an important challenge. Tumors oppose chemotherapeutic agents through a variety of mechanisms, with studies revealing that the tumor microenvironment (TME) is central to this process. The components of TME including stromal cells, immune cells, and non-stromal factors on exposure to chemotherapy promote the acquisition of resistant phenotype. Consequently, limited targeting of tumor cells leads to tumor recurrence after chemotherapy. Here, in this article, we summarize how TME alters chemotherapy responses in breast cancer. Furthermore, the role of different stromal cells viz., CAFs, TAMs, MSCs, endothelial cells, and cancer stem cells (CSC) in breast cancer chemoresistance is discussed in greater detail.

Effect of altitude and aspect on soil organic carbon and nitrogen stocks in the Himalayan Mawer Forest Range

Abstract: The soil organic carbon (SOC) and nitrogen (N) stocks in mountainous forests are influenced by the forest diversity, topographic features, and climate change impacts. Role of forest SOC and N stocks in global C cycle has been a subject of great research recently, but the effect of topographic features on their dynamics at the stand level has received less attention especially under temperate conditions. In order to find out how topographic aspect and altitude affect SOC and N budgets, a study was conducted in the Himalayan Mawer Forest Range. We examined SOC and N stocks at two altitude zones (Z1: 1800–2200 masl & Z2: 2200–2500 masl) under North (N) and South (S) aspects at three soil depths (D1: 0–20 cm, D2: 20–40 cm and D3: 40–60 cm). The SOC stock was found to be decreasing with altitude from 105.9 Mg ha− 1 to 78.3 Mg ha− 1 under N aspect and from 81.6 Mg ha− 1 to 74.0 Mg ha− 1 under S aspect. SOC stock was higher by 16.5% under N aspect as compared to S aspect. The results lead to the conclusion that altitude has a negative effect on SOC stabilization and therefore altitude and aspect effect may be included in SOC stock estimation equations.

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Abstract: Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate. Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.