Great Lakes Institute of Management

About: Great Lakes Institute of Management is a education organization based out in Chennai, India. It is known for research contribution in the topics: Population & Carbon. The organization has 2372 authors who have published 2543 publications receiving 65477 citations. The organization is also known as: Great Lakes & GLIM.

Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.

Abstract: 0.29 [95% confidence interval {CI}, 0.17 to 0.48]; P<0.001) and major adverse cardiovascular and cerebrovascular events (4.3% vs. 5.9%; hazard ratio, 0.71 [95% CI, 0.59 to 0.85]; P<0.001). The rate of myocardial infarction was lower with thienopyridine treatment than with placebo (2.1% vs. 4.1%; hazard ratio, 0.47; P<0.001). The rate of death from any cause was 2.0% in the group that continued thienopyridine therapy and 1.5% in the placebo group (hazard ratio, 1.36 [95% CI, 1.00 to 1.85]; P = 0.05). The rate of moderate or severe bleeding was increased with continued thienopyridine treatment (2.5% vs. 1.6%, P = 0.001). An elevated risk of stent thrombosis and myocardial infarction was observed in both groups during the 3 months after discontinuation of thienopyridine treatment. Conclusions Dual antiplatelet therapy beyond 1 year after placement of a drug-eluting stent, as compared with aspirin therapy alone, significantly reduced the risks of stent thrombosis and major adverse cardiovascular and cerebrovascular events but was associated with an increased risk of bleeding. (Funded by a consortium of eight device and drug manufacturers and others; DAPT ClinicalTrials.gov number, NCT00977938.)

Historical Trends in Lake and River Ice Cover in the Northern Hemisphere

Abstract: Freeze and breakup dates of ice on lakes and rivers provide consistent evidence of later freezing and earlier breakup around the Northern Hemisphere from 1846 to 1995. Over these 150 years, changes in freeze dates averaged 5.8 days per 100 years later, and changes in breakup dates averaged 6.5 days per 100 years earlier; these translate to increasing air temperatures of about 1.2°C per 100 years. Interannual variability in both freeze and breakup dates has increased since 1950. A few longer time series reveal reduced ice cover (a warming trend) beginning as early as the 16th century, with increasing rates of change after about 1850.

Technology in Parkinson's disease: Challenges and opportunities.

Abstract: The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.

Potential Abiotic and Biotic Impacts of Zebra Mussels on the Inland Waters of North America

Abstract: SYNOPSIS. The expansion of zebra mussel distribution into inland waterways of North America portends significant abiotic and biotic changes mediated either directly or indirectly by Dreissena . Dreissena fouls a wide array of submerged substrates including rock surfaces, macrophytes, native molluscs, canal and dock walls, and watercraft and motor outdrives. Fouling of water intake pipes and associated installations can severely impair water delivery to hydroelectric, municipal and industrial users, necessitating proactive or reactive control measures. Mussels increase water clarity by removing suspended clay, silt, bacteria, phytoplankton, and small zooplankton. Clear water phases associated with Dreissena grazing may exceed in magnitude and duration those generated by zooplankton grazing. Enhanced water clarity increases light transmittance and growth of benthic plants. Some benthic invertebrates {e.g., unionid molluscs) are adversely affected by Dreissena , whereas others, including amphipod crustaceans, exploit structure associated with or wastes generated by zebra mussels. Dreissena is exploited by a host of predators, most notably waterfowl, fish and crayfish. Waterfowl predators that consume contaminated Dreissena have elevated concentrations of organic pesticides and polychlorinated biphenyl compounds. Invasion of shallow lakes and ponds by Dreissena may divert production and biomass from pelagic to benthic foodwebs, shifting ecosystems to an alternative state.