Hospital Universitario La Paz

About: Hospital Universitario La Paz is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Medicine. The organization has 8960 authors who have published 11499 publications receiving 191509 citations.

Manometric findings in adult eosinophilic oesophagitis : a study of 12 cases

Abstract: ObjectiveTo describe the manometric findings detected in adult patients with dysphagia that were diagnosed of eosinophilic oesophagitis, and to compare with the cases of eosinophilic infiltration of the oesophagus reported in the literature.Patients and methodsWe present 12 adult patients diagnosed

The assessment of outcome after total knee arthroplasty: are we there yet?

Abstract: The routine use of patient reported outcome measures (PROMs) in evaluating the outcome after arthroplasty by healthcare organisations reflects a growing recognition of the importance of patients’ perspectives in improving treatment. Although widely embraced in the NHS, there are concerns that PROMs are being used beyond their means due to a poor understanding of their limitations. This paper reviews some of the current challenges in using PROMs to evaluate total knee arthroplasty. It highlights alternative methods that have been used to improve the assessment of outcome. Cite this article: Bone Joint J 2015;97-B:3–9.

Early systemic hypotension and vasopressor support in low birth weight infants: impact on neurodevelopment.

Abstract: BACKGROUND The duration and severity of systemic hypotension have been related with altered neurodevelopment Cerebral circulation is pressure-passive in low birth weight infants with early systemic hypotension who receive cardiovascular support The treatment of early systemic hypotension is controversial, because it has been associated with short-term and long-term morbidity in retrospective studies However, there has been no prospective information on cardiovascular support for hypotension and morbidity OBJECTIVE Our goal for this prospective study was to evaluate the effect on neurodevelopment resulting from the use of vasopressors/inotropes for early systemic hypotension METHODS Low birth weight infants with early systemic hypotension (<24 hours of life; study group) were assigned randomly to receive dopamine (25-10 microg/kg per minute) or epinephrine (0125-05 microg/kg per minute) in progressively larger doses until target blood pressure was attained (treatment-success subgroup) Hemodynamically stable patients who did not receive cardiovascular support were the control group Outcome measures were serial cranial ultrasound up to 40 weeks, structured neurologic evaluation (every 3 months), and neurodevelopmental test at 2 to 3 years of age RESULTS One hundred thirty patients were included (study = 60; treatment success = 38; controls = 70) Study-group patients had lower birth weight, gestational age, and 5-minute Apgar score, higher rates of premature rupture of membranes, need for cardiorespiratory resuscitation at birth, and sickness shortly after birth than the control group The patients in the study group also had significantly higher serum troponin I levels at birth Initial cranial ultrasound findings did not differ between groups, but the final cranial ultrasounds revealed higher rates of severe periventricular hemorrhage in the study group and higher rates of normal cranial ultrasounds in the control group Only the latter remained when the treatment-success subgroup and control group were compared Multivariate analysis did not detect any association between final cranial ultrasounds and the use of vasopressors/inotropes Sixteen infants died and 103 were followed up (90% survival rate) No differences between groups were found in the rates of abnormal neurologic status, developmental delay, or combined adverse outcome (death or cerebral palsy or severe neurodevelopmental delay) CONCLUSIONS Cautious use of cardiovascular support to treat early systemic hypotension in low birth weight infants seems to be safe The question of whether raising systemic blood pressure to within a normal range will improve outcome should be examined by using appropriate study designs

Does music perception have an impact on quality of life following cochlear implantation

Abstract: Conclusion. Despite the decrease in listening habits, about half of the patients still enjoy music post implantation. Better quality of sound through the implant improves music enjoyment and contri...