Institution
Hospital Universitario La Paz
Healthcare•Madrid, Spain•
About: Hospital Universitario La Paz is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Medicine. The organization has 8960 authors who have published 11499 publications receiving 191509 citations.
Topics: Population, Medicine, Cancer, Transplantation, Haemophilia
Papers published on a yearly basis
Papers
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TL;DR: Changes in the phosphorylation states of both FAK and Pyk2 tyrosine kinases at focal contacts underlie impaired bone-forming cell attachment after exposure to Ti particles of micrometric sizes.
53 citations
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Boston Children's Hospital1, University College Hospital2, Imperial College Healthcare3, University of Padua4, UCL Institute of Child Health5, Hospital General Universitario Gregorio Marañón6, University of Barcelona7, Hospital Sant Joan de Déu Barcelona8, Hospital Universitario La Paz9, Complutense University of Madrid10
TL;DR: Early ART start and improving adherence in perinatally HIV-1–infected children minimize the size of viral reservoir and are linked with lower total HIV- 1 DNA.
Abstract: Background: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. Setting: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected children starting antiretroviral therapy (ART) <6 months of age. Methods: Total HIV-1 DNA was measured from 51 long-term suppressed children aged 6.3 years (median) after initial viral suppression. Factors associated with log10 total HIV-1 DNA were analyzed using linear regression. Results: At ART initiation, children were aged median [IQR] 2.3 [1.2-4.1] months, CD4% 37 [24-45] %, CD8% 28 [18-36] %, log10 plasma viral load (VL) 5.4 [4.4-5.9] copies per milliliter. Time to viral suppression was 7.98 [4.6-19.3] months. After suppression, 13 (25%) children had suboptimal response [≥2 consecutive VL 50-400 followed by VL <50] and/or experienced periods of virological failure [≥2 consecutive VL ≥400 followed by VL <50]. Median total HIV-1 DNA was 43 [6195] copies/106 PBMC. Younger age at therapy initiation was associated with lower total HIV-1 DNA (adjusted coefficient [AC] 0.12 per month older, P = 0.0091), with a month increase in age at ART start being associated with a 13% increase in HIV DNA. Similarly, a higher proportion of time spent virally suppressed (AC 0.10 per 10% higher, P = 0.0022) and the absence of viral failure/suboptimal response (AC 0.34 for those with fail/suboptimal response, P = 0.0483) were associated with lower total HIV-1 DNA. Conclusions: Early ART initiation and a higher proportion of time suppressed are linked with lower total HIV-1 DNA. Early ART start and improving adherence in perinatally HIV-1-infected children minimize the size of viral reservoir.
53 citations
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TL;DR: This work will review different hand injuries in infants and provide basic rules for their treatment and followup, and compare the experience with published results.
Abstract: Hand injuries in infants are an exciting challenge for those who treat pediatric trauma patients. We will review different hand injuries and provide basic rules for their treatment and followup. We will compare our experience with published results. When compared with adults, two main differences arise in treatment of pediatric hand injuries: children have an exceptional regenerative ability that allows procedures to be used that would not be useful in older patients (eg, replantation after avulsion injuries) and children have a high degree of cooperation with physicians. The main goal of treatment should be to have children return quickly to their daily leisure and academic activities.
53 citations
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TL;DR: A nationwide survey of the variable 5′ emm (M protein gene) sequences from 614 pharyngeal Streptococcus pyogenes isolates susceptible and resistant to erythromycin indicated that high frequency of eryhromycin resistance in Spain is due to few clones.
Abstract: We conducted a nationwide survey of the variable 5′ emm (M protein gene) sequences from 614 pharyngeal Streptococcus pyogenes isolates susceptible (299 isolates) and resistant (315 isolates) to erythromycin that were isolated in Spain from 1996 to 1999. Almost 98% of these isolates had emm sequences in agreement with previously recorded M antigen association. We only identified a new 5′ emm sequence in 17 isolates. Nine different emm types accounted for 85% of the S. pyogenes isolates susceptible to erythromycin. By contrast, only 3 emm types accounted for 70% of the erythromycin-resistant isolates. Further characterization of these isolates by ribotyping and pulsed-field gel electrophoresis indicated that high frequency of erythromycin resistance in Spain is due to few clones.
53 citations
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TL;DR: The Bonebridge implant is a promising transcutaneous bone conduction implant for patients with conductive hearing loss and aided thresholds demonstrate a significant benefit, with an improvement from 68dB to 25dB.
53 citations
Authors
Showing all 9020 results
Name | H-index | Papers | Citations |
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Jaakko Tuomilehto | 115 | 1285 | 210682 |
Vincent Soriano | 87 | 762 | 34084 |
Lina Badimon | 86 | 682 | 35774 |
Francisco J. Blanco | 84 | 789 | 33319 |
Michael A. Gatzoulis | 82 | 478 | 32562 |
Jose Lopez-Sendon | 81 | 460 | 41809 |
Victor Moreno | 80 | 635 | 31511 |
Joaquín Dopazo | 75 | 396 | 24790 |
Fernando Rodríguez-Artalejo | 74 | 512 | 23296 |
José R. Banegas | 74 | 421 | 28249 |
Michael Becker | 72 | 317 | 18189 |
Gianfranco Ferraccioli | 70 | 402 | 26515 |
Maria-Victoria Mateos | 66 | 480 | 24278 |
Manuel Romero-Gómez | 64 | 420 | 19006 |
Eulogio García | 63 | 270 | 15354 |