Institution
Hyogo College of Medicine
Education•Nishinomiya, Hyôgo, Japan•
About: Hyogo College of Medicine is a education organization based out in Nishinomiya, Hyôgo, Japan. It is known for research contribution in the topics: Cancer & Transplantation. The organization has 5030 authors who have published 10629 publications receiving 258734 citations. The organization is also known as: Hyōgo ika daigaku.
Topics: Cancer, Transplantation, Population, Medicine, Survival rate
Papers published on a yearly basis
Papers
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TL;DR: GCAP could be effective for inducing remission and improving quality of life in patients with active Crohn’s disease that is refractory to conventional therapy.
Abstract: Background
Active Crohn’s disease (CD) is often associated with elevated levels of platelets, granulocytes, and monocytes that are activated and resistant to apoptosis. The level of neutrophils in the intestinal mucosa has been quantitatively related to the severity of intestinal inflammation in CD. We postulated that patients with CD that is refractory to conventional medications might respond to a reduction of granulocytes and monocytes by adsorptive apheresis.
90 citations
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TL;DR: It is demonstrated that Stat3 activation is required for efficient T cell proliferation by IL-2 throughIL-2Ralpha induction, which is responsible for IL-1- and IL-6-induced proliferation through distinct mechanisms.
Abstract: Stat3, a member of signal transducers and activators of transcription (STAT), is activated by a variety of cytokines. Recently, mice lacking Stat3 specifically in T cells have been generated and shown to be defective in IL-6-induced proliferation due to the impairment in IL-6-mediated prevention of apoptosis. In the present study, we show that Stat3-deficient T cells are partially defective in IL-2-induced proliferation. Stat3-deficient T cells show impaired IL-2-mediated IL-2 receptor (IL-2R) alpha chain expression. When Stat3-deficient T cells are stimulated with high-dose IL-2, these T cells express IL-2Ralpha and proliferate to similar extents as wild-type T cells. These demonstrate that Stat3 activation is required for efficient T cell proliferation by IL-2 through IL-2Ralpha induction. Taken together, these findings demonstrate that Stat3 activation in T cells is responsible for IL-2- and IL-6-induced proliferation through distinct mechanisms.
90 citations
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TL;DR: In vivo IL-33 treatment significantly increased the capacity of T cells in the cervical lymph nodes of RW-immunized mice to produce IL-4, IL-5 and IL-13 upon challenge with anti- CD3 and anti-CD28 antibodies in vitro.
Abstract: IL-33, a member of the IL-1 family of cytokines, is the ligand for ST2 (IL-33Ralpha chain). IL-33 has the capacity to induce T(h)2 cytokine production from T(h)2 cells, mast cells and basophils, indicating that IL-33 has the potential to induce T(h)2 cytokine-mediated allergic inflammation of the eye. Thus, we tested the pathological role of IL-33 in allergic conjunctivitis (AC). As reported elsewhere, animals immunized with ragweed pollen (RW)/alum and boosted with RW/PBS developed AC promptly (within 15 min) and conjunctival eosinophilic inflammation after a delay (within 24 h) in response to eye drop challenge with RW. Furthermore, RW-immunized mice, when topically challenged with both RW and IL-33, developed more striking eosinophilia in their conjunctiva without exacerbation of the clinical AC score. This in vivo IL-33 treatment significantly increased the capacity of T cells in the cervical lymph nodes of RW-immunized mice to produce IL-4, IL-5 and IL-13 upon challenge with anti-CD3 and anti-CD28 antibodies in vitro. Furthermore, the infiltrating cells were largely eosinophils and a small proportion of CD4(+) T cells, both of which express ST2. We also found that even splenic eosinophils express ST2 and show increased expression in response to IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF) or IL-33. Eosinophils, stimulated with IL-5 and/or GM-CSF, are responsive to IL-33, which induces production of IL-4 and chemokines. Finally, we showed that conjunctival tissues constitutively express biologically active IL-33, suggesting that IL-33 might play a crucial role in the induction and augmentation of AC.
90 citations
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TL;DR: It is concluded that high-dose-rate intracavitary irradiation following external irradiation is an effective treatment modality for esophageal carcinoma, especially in a limited stage.
90 citations
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TL;DR: TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Aβ-afferent nerves with a density over 3,000-fold higher than that on their somas and are required for rapid AP repolarization at the NRs.
90 citations
Authors
Showing all 5043 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
James G. Fujimoto | 165 | 1115 | 116451 |
Kiyoshi Takeda | 129 | 416 | 109817 |
David A. Brenner | 128 | 499 | 52756 |
Akira Yamamoto | 117 | 1999 | 74961 |
Osamu Takeuchi | 116 | 288 | 90116 |
Takaomi C. Saido | 90 | 352 | 27802 |
Taroh Kinoshita | 87 | 379 | 23714 |
Takenobu Kamada | 86 | 700 | 27535 |
Kazuhiko Nakagawa | 84 | 917 | 41018 |
Takashi Yamamoto | 84 | 1401 | 35169 |
Taro Kawai | 83 | 141 | 66916 |
Hiroo Imura | 83 | 781 | 29276 |
Kunio Matsumoto | 82 | 465 | 25131 |
Yukihiko Kitamura | 80 | 419 | 37965 |