Institution
Hyogo College of Medicine
Education•Nishinomiya, Hyôgo, Japan•
About: Hyogo College of Medicine is a education organization based out in Nishinomiya, Hyôgo, Japan. It is known for research contribution in the topics: Cancer & Transplantation. The organization has 5030 authors who have published 10629 publications receiving 258734 citations. The organization is also known as: Hyōgo ika daigaku.
Topics: Cancer, Transplantation, Population, Medicine, Survival rate
Papers published on a yearly basis
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TL;DR: The ATI method showed good diagnostic capability for the detection of hepatic steatosis in patients with non-alcoholic fatty liver disease and in obese patients.
Abstract: We investigated the diagnostic capability of the proprietary attenuation imaging (ATI) modality found on some Canon Medical Systems Corp. ultrasound scanners to detect histologically diagnosed steatosis in 148 patients. ATI values increased significantly with increasing steatosis grade (p 66% of hepatocytes) were 0.85, 0.91 and 0.91. In addition, ATI values increased significantly with increasing steatosis grades (p = 0.002) even in obese patients (n = 41). The diagnostic values of ATI for steatosis grades ≥ 1, ≥ 2 and 3 in obese patients were 0.72, 0.72 and 0.78. Furthermore, ATI values increased significantly with increasing steatosis grade (p
95 citations
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Nagoya University1, Kobe University2, Hokkaido University3, Yamaguchi University4, Boston Children's Hospital5, Tokai University6, Nihon University7, Toho University8, Kyoto Prefectural University of Medicine9, Hyogo College of Medicine10, Kyushu University11, Kyorin University12, Kyoto University13
TL;DR: It is suggested that SCT from an alternative donor offers a better chance of FFS than a second IST in patients not responding to an initial IST in children with acquired aplastic anemia who failed to respond to anInitial IST.
95 citations
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TL;DR: The results suggest that TRPA1‐dependent orofacial and spinal nociceptive input is processed mainly in the superficial laminae of the Vc and DH in a specific manner and may be processed differently between the rostral TSN and Vc.
Abstract: Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is known about the processing of the TRPA1-mediated nociceptive information within the trigeminal sensory nuclei (TSN) and the spinal dorsal horn (DH). To address this issue, we characterized the TRPA1-positive (+) neurons in the trigeminal ganglion (TG) and investigated the distribution of TRPA1(+) afferent fibers and their synaptic connectivity within the rat TSN and DH by using light and electron microscopic immunohistochemistry. In the TG, TRPA1 was expressed in unmyelinated and small myelinated axons and also occasionally in large myelinated axons. Many TRPA1(+) neurons costained for the marker for peptidergic neurons substance P (26.8%) or the marker for nonpeptidergic neurons IB4 (44.5%). In the CNS, small numbers of axons and terminals were immunopositive for TRPA1 throughout the rostral TSN, in contrast to the dense network of positive fibers and terminals in the superficial laminae of the trigeminal caudal nucleus (Vc) and DH. The TRPA1(+) terminals contained clear round vesicles, were presynaptic to one or two dendrites, and rarely participated in axoaxonic contacts, suggesting involvement in relatively simple synaptic circuitry with a small degree of synaptic divergence and little presynaptic modulation. Immunoreactivity for TRPA1 was also occasionally observed in postsynaptic dendrites. These results suggest that TRPA1-dependent orofacial and spinal nociceptive input is processed mainly in the superficial laminae of the Vc and DH in a specific manner and may be processed differently between the rostral TSN and Vc.
95 citations
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TL;DR: It is shown for the first time that purified H. pylori urease predominantly stimulates the B-1-cell population rather than B-2 cells, which produce antigen-specific conventional antibodies among splenic B220+ B cells.
Abstract: Besides various gastroduodenal diseases, Helicobacter pylori infection may be involved in autoimmune disorders like rheumatoid arthritis (RA) or idiopathic thrombocytopenic purpura. Such autoimmune disorders are often associated with autoreactive antibodies produced by B-1 cells, a subpopulation of B lymphocytes. These B-1 cells are mainly located in the pleural cavity or mucosal compartment. The existence of H. pylori urease-specific immunoglobulin A (IgA)-producing B cells in the mucosal compartment and of their specific IgM in the sera of acutely infected volunteers suggests the possibility that urease stimulates mucosal innate immune responses. Here, we show for the first time that purified H. pylori urease predominantly stimulates the B-1-cell population rather than B-2 cells, which produce antigen-specific conventional antibodies among splenic B220+ B cells. The fact that such stimulation of B-1 cells was not affected by the addition of polymyxin B indicates that the effect of purified H. pylori urease was not due to the contamination with bacterial lipopolysaccharide. Furthermore, the production of various B-1-cell-related autoreactive antibodies such as IgM-type rheumatoid factor, anti-single-stranded DNA antibody, and anti-phosphatidyl choline antibody was observed when the splenic B cells were stimulated with purified H. pylori urease in vitro. These findings suggest that H. pylori components, urease in particular, may be among the environmental triggars that initiate various autoimmune diseases via producing autoreactive antibodies through the activation of B-1 cells. The findings shown here offer important new insights into the pathogenesis of autoimmune disorders related to H. pylori infection.
95 citations
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TL;DR: Protective effects of human recombinant superoxide dismutase against ischemic neuronal damage are demonstrated and support the hypothesis that the generated free radicals induce a vicious cycle leading to delayed neuronal death.
Abstract: It has been postulated that oxygen-derived free radicals are produced in significant quantities upon reperfusion of ischemic brain and that the free radicals play a pivotal role in triggering the ischemic neuronal damage causing delayed neuronal death. This study was undertaken to examine the effects of human recombinant superoxide dismutase on the delayed neuronal death of CA1 neurons and on the change in the expression of messenger ribonucleic acid for endogenous copper-zinc superoxide dismutase after transient ischemia.Human recombinant superoxide dismutase (8 x 10(5) units/kg) or apo-superoxide dismutase was administered intravenously 1 minute before bilateral carotid artery occlusion in gerbils divided among four experimental groups. Endogenous copper-zinc superoxide dismutase messenger ribonucleic acid was analyzed by in situ hybridization histochemistry using a sulfur-35-labeled oligonucleotide probe. Immunohistochemical localizations of administered human recombinant superoxide dismutase were inve...
95 citations
Authors
Showing all 5043 results
Name | H-index | Papers | Citations |
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Shizuo Akira | 261 | 1308 | 320561 |
James G. Fujimoto | 165 | 1115 | 116451 |
Kiyoshi Takeda | 129 | 416 | 109817 |
David A. Brenner | 128 | 499 | 52756 |
Akira Yamamoto | 117 | 1999 | 74961 |
Osamu Takeuchi | 116 | 288 | 90116 |
Takaomi C. Saido | 90 | 352 | 27802 |
Taroh Kinoshita | 87 | 379 | 23714 |
Takenobu Kamada | 86 | 700 | 27535 |
Kazuhiko Nakagawa | 84 | 917 | 41018 |
Takashi Yamamoto | 84 | 1401 | 35169 |
Taro Kawai | 83 | 141 | 66916 |
Hiroo Imura | 83 | 781 | 29276 |
Kunio Matsumoto | 82 | 465 | 25131 |
Yukihiko Kitamura | 80 | 419 | 37965 |