Institution
Institute of Technology, Tallaght
About: Institute of Technology, Tallaght is a based out in . It is known for research contribution in the topics: Burkholderia cepacia complex & Cyclic voltammetry. The organization has 296 authors who have published 497 publications receiving 10868 citations. The organization is also known as: ITT Dublin & Tallaght Regional Technical College.
Topics: Burkholderia cepacia complex, Cyclic voltammetry, Catalysis, Burkholderia cenocepacia, Higher education
Papers published on a yearly basis
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TL;DR: Gallidermin shows most promise as a therapeutic agent, with relatively low cytotoxicity and potent antimicrobial activities, and Melittin, while showing little potential as an antimicrobial agent, may have potential in delivery of poorly bioavailable drugs.
225 citations
TL;DR: Moderate workloads, coupled with moderate-low to moderate-high acute:chronic workload ratios, appear to be protective for professional soccer players.
192 citations
TL;DR: A systematic review of the coordination chemistry of calix[4]arenes, which have been functionalised at the lower rim and are in the cone conformation, is presented in this article.
188 citations
TL;DR: All of the compounds investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria were found to have excellent anti-Candida activity but were inactive against Staphylococcus aureus and Escherichia coli.
188 citations
TL;DR: The chemical aspects regarding lipid A and its role in innate immunity are described and discussed, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level.
Abstract: In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level.
178 citations
Authors
Showing all 296 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Kevin Kavanagh | 56 | 302 | 9519 |
| Hans Gregersen | 52 | 475 | 10987 |
| Baljit Singh | 39 | 340 | 5996 |
| Malachy McCann | 39 | 145 | 4697 |
| Michael Devereux | 36 | 105 | 3704 |
| Siobhán McClean | 34 | 98 | 3317 |
| Bernadette S. Creaven | 30 | 69 | 2557 |
| Denise A. Egan | 28 | 42 | 2860 |
| Mauricio Krause | 27 | 57 | 1838 |
| Eithne Dempsey | 26 | 96 | 2103 |
| Mark Lyons | 26 | 83 | 1933 |
| Andrew Kellett | 25 | 58 | 1691 |
| Dominic A. Doran | 24 | 60 | 1797 |
| Kevin N. Keane | 23 | 63 | 2449 |
| Sam Maher | 23 | 41 | 1598 |