D
Denise A. Egan
Researcher at Institute of Technology, Tallaght
Publications - 42
Citations - 3089
Denise A. Egan is an academic researcher from Institute of Technology, Tallaght. The author has contributed to research in topics: Cell culture & Cell cycle. The author has an hindex of 28, co-authored 42 publications receiving 2860 citations. Previous affiliations of Denise A. Egan include Dublin City University.
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Journal ArticleDOI
The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds
TL;DR: Coumarin-Related Compounds and Drug Metabolism Reviews: Vol.
Journal ArticleDOI
Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases
Bernadette S. Creaven,Brian Duff,Denise A. Egan,Kevin Kavanagh,Georgina M. Rosair,Venkat Reddy Thangella,Maureen Walsh +6 more
TL;DR: All of the compounds investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria were found to have excellent anti-Candida activity but were inactive against Staphylococcus aureus and Escherichia coli.
Journal ArticleDOI
Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands.
Michael Devereux,Denis O Shea,Andrew Kellett,Andrew Kellett,Malachy McCann,Maureen Walsh,Denise A. Egan,Carol Deegan,Kinga Kędziora,Georgina M. Rosair,Helge Müller-Bunz +10 more
TL;DR: The catalase and superoxide dismutase (SOD) activities of the four complexes along with those of the known phenanthroline complexes were investigated and the structural results for 4 represent a re-examination of this crystallographically known compound for which no hydrogen atom coordinates have been previously reported.
Journal ArticleDOI
Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.
TL;DR: A derivative of coumarin, 8-nitro- 7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised and was shown to be non-mutagenic in a standard Ames test, both with or without a mammalian enzyme activation system.
Journal ArticleDOI
In vitro cytotoxic potential and mechanism of action of selected coumarins, using human renal cell lines.
TL;DR: Results would suggest that 6-NO(2)-7- OHC and 7,8-OHC might have a therapeutic role to play in the treatment of renal cell carcinoma.