Institution
Montreal Children's Hospital
Healthcare•Montreal, Quebec, Canada•
About: Montreal Children's Hospital is a healthcare organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 3842 authors who have published 4816 publications receiving 200198 citations.
Topics: Population, Poison control, Gene, Medicine, Kidney
Papers published on a yearly basis
Papers
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TL;DR: The prevalence rate of epileptiform abnormalities is greater in children with attention-deficit-hyperactivity disorder compared with that observed in normal school-aged children when hyperventilation and photic stimulation are used, however, the clinical utility of routine electroencephalography in the diagnosis of a comorbid seizure disorder in childrenWith attention- deficit- hyperactivity disorder is limited.
120 citations
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120 citations
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TL;DR: For injuries in Montreal and all of urban Canada, the pattern of socio-economic inequality in the annual incidence rates by quintile was very pronounced, completely regular and highly significant, and the rates for each sex were consistently highest in the poorest income quintile.
Abstract: This paper examines motor vehicle traffic accident deaths and injuries to pedestrians and bicyclists (ICD-9 codes E813-E814) aged 0-14 years, by income quintile of area of residence. It is based on 92 deaths in urban Canada in 1981, 69 deaths in Montreal during the period 1979-1983, and 1,133 injuries which resulted in hospital care or police reports in Montreal in 1981. For injuries in Montreal, the pattern of socio-economic inequality in the annual incidence rates by quintile was very pronounced, completely regular and highly significant. The rate of injury to children living in the poorest neighbourhoods was four times that of children living in the least poor neighbourhoods. For both sexes, inequalities were much more pronounced for pedestrians compared to bicyclists. For deaths in Montreal and all of urban Canada, the inequality in the rates did not follow such a consistent pattern across the income quintiles, nor were the differences statistically significant in most cases, but the rates for each sex were consistently highest in the poorest income quintile. Socio-economic inequalities in the rates of death and injury were greater in girls than in boys. The results are discussed in the context of theories of etiology and strategies for prevention. Language: en
120 citations
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TL;DR: In this review, peroxisome biology and PBD are discussed, and research contributions to pathophysiology and treatment are discussed.
Abstract: The peroxisome biogenesis disorders (PBD) are a heterogeneous group of autosomal recessive disorders in which peroxisome assembly is impaired, leading to multiple peroxisome enzyme deficiencies, complex developmental sequelae and progressive disabilities. Mammalian peroxisome assembly involves the protein products of 16 PEX genes; defects in 14 of these have been shown to cause PBD. Three broad phenotypic groups are described on a spectrum of severity: Zellweger syndrome is the most severe, neonatal adrenoleukodystrophy is intermediate and infantile Refsum disease is less severe. Another group is Rhizomelic chondrodysplasia punctata spectrum. Recently, atypical phenotypes have been described, indicating that the full spectrum of these disorders remains to be identified. For most patients, there is a correlation between clinical severity and effect of the mutation on PEX protein function. Diagnosis relies on biochemical measurements of peroxisome functions and PEX gene sequencing. There are no targeted therapies, although management protocols have been suggested and research endeavors continue. In this review we will discuss peroxisome biology and PBD, and research contributions to pathophysiology and treatment.
119 citations
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TL;DR: Serum immunoreactive parathyroid hormone (IPTH) is normal in patients with X-linked hypophosphatemic rickets who are not treated with phosphate salts and endogenous IPTH does not influence the existing defect in tubular reabsorption of phosphate in male patients.
Abstract: Serum immunoreactive parathyroid hormone(IPTH) is normal in patients with X-linked hypophosphatemic rickets who are not treated with phosphate salts. Phosphate raises IPTH in these patients. Endogenous IPTH does not influence the existing defect in tubular reabsorption of phosphate in male patients.
119 citations
Authors
Showing all 3844 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Matthews | 140 | 617 | 88802 |
Joost J. Oppenheim | 130 | 454 | 59601 |
Michael Camilleri | 125 | 1084 | 58867 |
James M. Swanson | 117 | 415 | 47131 |
Rhian M. Touyz | 114 | 620 | 43738 |
Ian Roberts | 112 | 714 | 51933 |
William D. Foulkes | 108 | 682 | 45013 |
Stephen P. Hinshaw | 106 | 330 | 37336 |
Michael S. Kramer | 104 | 568 | 43803 |
Liam Smeeth | 104 | 753 | 53433 |
Eric Fombonne | 100 | 336 | 44447 |
Douglas L. Arnold | 100 | 624 | 37040 |
Erwin W. Gelfand | 99 | 675 | 36059 |
Frederick Andermann | 90 | 365 | 25638 |
Robert W. Platt | 88 | 638 | 31918 |