Montreal Children's Hospital

About: Montreal Children's Hospital is a healthcare organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 3842 authors who have published 4816 publications receiving 200198 citations.

Studies on the hyperactive child. VI. Prenatal and paranatal factors associated with hyperactivity.

Abstract: SUMMARY In this study the birth records of 56 hyperactive children were compared with 56 controls with respect to 23 different prenatal and paranatal complications. The only significant difference was that more hyperactive than normal children were born following an abnormally short or long labour which was further complicated by the use of forceps. There was no evidence, however, that the mothers of hyperactive children either suffered from or were more predisposed to have difficulties producing brain-damage in their offspring than were the mothers of normal children. There is evidence that important information regarding the child's birth process is commonly withheld from the mother by her medical attendants. The hypothesis that chronic hyperactivity is frequently the result of complications of pregnancy and delivery receives little support from this study. RESUME Dans cette etude ont ete comparees les fiches de naissance de 56 enfants hyperactifs et celles de 56 controles en fonction de 23 difierentes complications pre-et peri-natales. II n'a ete tzouve qu'une seule differente significative: plus d'enfants hyperactifs que d'enfants normaux etaient nes a la suite d'un travail anormalement court ou long, complique davantage encore par l'emploi de forceps. II n'y a aucune preuve pourtant que les meres des enfants hyperactifs aient ete plus predisposees aux difficultes produisant une lesion cerebrate chez l'enfants que les meres d'enfants normaux. Paz ailleurs il est evident que des informations importantes au sujet du processus de la naissance de leur enfant sont communement cachees aux meres par leur medecin. Cette etude n'apporte pas grand support a l'hypothese selon iaquelle l'hyperactivite chronique est frequemment le resultat de complications de la grossesse ou de Taccouchement. ZUSAMMENFASSUNG In dieser Untersuchung werden die Geburtsverlaufe von 56 hyperaktiven Kindern mil 56 Kontrollen hinsichtlich 23 verschiedener pra-und paranataler Komplikationen ver-glichen. Der einzige bedeutsame Unterschied bestand darin, daβ mehr hyperaktive als normale Kinder nach einer ungewohnlich kurzen oder langen, durch Zangenanwendung weiterhin komplizierten Geburt geboren wurden. Es fand sich jedoch kein Hinweis dafur, daβ Mutter von hyperaktiven Kindern mehr als andere zu Erkrankungen neigen, welche Hirnschaden bei den Feten erzeugen. Die Studie ergab, daβ die Geburtshelfer haufig wichtige Informationen hinsichtlich des Geburtsvorganges der Mutter vorenthalten. Die Hypothese, daβ chronische Hyperaktivitat haufig das Ergebnis von Schwanger-schafts-oder Entbindungskomplikationen ist, bekommt durch diese Untersuchungen eine geringe Stutze. RESUME Se compararon los registros de nacimiento de 56 ninos hiperactivos con los de 56 ninos de testigo con respecto a 23 complicaciones prenatales y paranatales distintas. La unica diferencia significante era que mas ninos hiperactivos que ninos normales nacieron despues de un parto anormalmente corto o largo, complicado ademas por el empleo de forceps. No habia evidencia, sin embargo, de que las madres de ninos hiperactivos o tuvieran o fueran mas predispuestas a tener dificultades que producieran dano cerebral, que las madres de ninos normales. Hay evidencia de que informes importantes sobre el parto se esconden muchas veces de la madre por el personal medico. La hipotesis que una hiperactividad cronica resulta frecuentemente de complicaciones del embarazo y del parto tiene muy poca confirmacion del estudio actual.

Prevention of Laboratory-Acquired Brucellosis

Abstract: Brucellosis is one of the most common laboratory-acquired infections, mostly because aerosolization is a mechanism of transmission in this setting. We report an exposure to Brucella melitensis that occurred in a large microbiology laboratory and describe the strategy chosen for antibiotic prophylaxis and serological follow-up of exposed workers.

Dynamic stromal‐epithelial interactions during progression of MCF10DCIS.com xenografts

Abstract: MCF10DCIS.com cells form comedo type ductal carcinoma in situ in immune-deficient mice before forming invasive ductal carcinoma. As the lesions mature, both stromal and epithelial cells undergo phenotypic changes detected by immunohistochemistry. Myofibroblasts are present before the formation of carcinoma in situ and after development of invasive carcinoma. MCF10DCIS. com lesions develop a myoepithelial layer prior to exhibiting a basement membrane surrounding the ductal mass. TGFbeta1 is initially expressed by the epithelial cells but is expressed by stroma in invasive carcinoma. Stromal derived factor-1 is detected in epithelial cells in early carcinoma in situ but is produced in stromal cells in invasive carcinoma. The receptor CXCR4 is expressed by epithelial cells in the xenografts at all times, as is the hepatocyte growth factor receptor c-met. MCF10DCIS.com xenografts illustrate the dynamic interplay of epithelium and stroma in the development of carcinoma in situ and subsequent invasive carcinoma. Although the phenotype of the epithelial cells may be dependent upon the stroma, the malignant epithelium induces the development of the stroma necessary for progression to the invasive stage. (c) 2007 Wiley-Liss, Inc.