Sathyabama University

About: Sathyabama University is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Wireless sensor network & Diesel fuel. The organization has 5993 authors who have published 5948 publications receiving 47033 citations.

Electrospun Nd3+‐Doped LiMn2O4 Nanofibers as High‐Performance Cathode Material for Li‐Ion Capacitors

Abstract: Electrospun high voltage spinel type LiNd0.01Mn1.99O4 nanofibers (LNdMO NF) were prepared successfully by electrospinning technique. The thermal behaviour of electrospun precursor fibrous mat was performed by TG/DTA analysis. The crystallite structure and phase purity of Nd3+ doped LiMn2O4 was confirmed by X-ray diffraction studies. The chemical structure of electrospun LNdMO NF was characterized by Raman spectroscopy studies. The morphology feature of the nanofibers was examined by field emission scanning electron microscopy. Li-ion capacitor (LIC) coin cell was fabricated by using high voltage intersion LNdMO NF as cathode and black pearl carbon as anode with electrospun PVdF membrane containing 1M LiNO3 as the separator as well as electrolyte. The electrochemical performance of assembled LIC coin cell was characterized by cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy. LIC was capable of operating in wide potential window of 1.6 V with excellent capacitance retention of 86% even after 2500 continuous galvanostatic charge-discharge cycles at a constant current density of 1 A g-1. Furthermore, LIC delivered an energy density of 17 Wh kg-1 and a power density of 397 W kg-1. Moreover, this results show that Nd3+ doped LiMn2O4 nanofibers can be considered as a promising electroactive cathode material for Li-ion capacitor.

Facile synthesis of α-Fe2O3/WO3 composite with an enhanced photocatalytic and photo-electrochemical performance

Abstract: The influence of hematite iron oxide (α-Fe2O3) nanoparticles in tungsten oxide (WO3) nanorods photocatalyst on photodegradation of organic pollutant was investigated in the present work. The spherical-shaped α-Fe2O3 nanoparticles and WO3 nanorods were synthesized from citrate precursor and hydrothermal routes respectively. The different weight percentage (wt%) ratios (1, 2, and 3 wt%) of α-Fe2O3 added heterostructured α-Fe2O3/WO3 composite photocatalysts by a simple physical mixing process. The photocatalytic activities of as-synthesized photocatalysts were evaluated by photodegradation of methylene blue (MB) under visible-light irradiation. It showed that the 2% α-Fe2O3/WO3 composite exhibited excellent photocatalytic activity than the others. This enhancement could be attributed to its strong absorption in the visible region and the low recombination rate of electron-hole pairs. In addition, the photo-electrochemical measurements of the 2% α-Fe2O3/WO3 composite revealed the faster migration of the photo-excited charge-carriers. Hence, this study demonstrates the heterostructured α-Fe2O3/WO3 composite as a promising candidate for environmental remediation.

Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors

Abstract: Histone deacetylases 2 (HDAC2), Class I histone deacetylase (HDAC) family, emerged as an important therapeutic target for the treatment of various cancers. A total of 48 inhibitors of two different chemotypes were used to generate pharmacophore model using 3D QSAR pharmacophore generation (HypoGen algorithm) module in Discovery Studio. The best HypoGen model consists of four pharmacophore features namely, one hydrogen bond acceptor (HBA), and one hydrogen donor (HBD), one hydrophobic (HYP) and one aromatic centres, (RA). This model was validated against 20 test set compounds and this model was utilized as a 3D query for virtual screening to validate against NCI and Maybridge database and the hits further screened by Lipinski’s rule of 5, and a total of 382 hit compounds from NCI and 243 hit compounds from Maybridge were found and were subjected to molecular docking in the active site of HDAC2 (PDB: 3MAX). Finally eight hit compounds, NSC108392, NSC127064, NSC110782, and NSC748337 from NCI database and MFCD01935795, MFCD00830779, MFCD00661790, and MFCD00124221 from Maybridge database, were considered as novel potential HDAC2 inhibitors.

Optimization of rhamnolipid biosurfactant production from Serratia rubidaea SNAU02 under solid-state fermentation and its biocontrol efficacy against Fusarium wilt of eggplant

Abstract: This work was aimed to explore rhamnolipid production under solid state fermentation using a potential substrate mahua oil cake and to evaluate the biocontrol efficacy of rhamnolipid against Fusarium wilt of eggplant. The combination of Response Surface Methodology and Central Composite Design was employed to optimize higher biosurfactant production. Therefore, four factors viz., substrate concentration, inoculum size, pH and temperature were selected for optimization of rhamnolipid production. The results revealed that the optimum conditions for reduction of surface tension were mahua oil cake 7.78 g, 2.4 ml inoculum size (1 × 108 cells/ml), pH 7 and 30° C temperature. To evaluate the biocontrol efficacy the application of rhamnolipid at various concentrations (0, 100, 250 and 500 μg/ml) by soil and foliar application were employed in the pot culture assay. In vitro study indicated that rhamnolipid producing strain SNAU02 was the most effective antagonist against Fusarium oxysporum f. sp. melongenae and used for pot culture study. On the basis of economic analysis, treatment T9 (Fusarium oxysporum f. sp. Melongenae ( × 106 spores/ml) + 50 ml of 250 μg biosurfactant/ml to soil + foliar spraying of biosurfactant (250 μg/ml) ranked among the efficacious treatments and was just as effective as a synthetic fungicide. In control treatment, occurrence of disease severity and disease incidence was observed from early stage of crop growth until harvest stage. The pot experiment results indicated that SNAU02 rhamnolipid could be a promising agent in the biocontrol of Fusarium wilt of eggplant, which might help to minimize the yield loss of eggplant.