Institution
Sewanee: The University of the South
Education•Sewanee, Tennessee, United States•
About: Sewanee: The University of the South is a education organization based out in Sewanee, Tennessee, United States. It is known for research contribution in the topics: Population & Species richness. The organization has 8995 authors who have published 14790 publications receiving 320138 citations. The organization is also known as: Sewanee & The University of the South.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A multistep and multikinase model for Dvl activation in the Wnt/β-catenin pathway is proposed that uncovers a built-in de-activation mechanism that is triggered by activating phosphorylation of Dvl by CK1δ/ϵ.
103 citations
••
18 Mar 2021
TL;DR: Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head and neck, lung, ovarian, testicular cancers, and sarcoma as mentioned in this paper.
Abstract: Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head and neck, lung, ovarian, testicular cancers, and sarcoma. Cisplatin is commonly administered intravenously as a first-line chemotherapy for patients suffering from various malignancies. Upon absorption into the cancer cell, cisplatin interacts with cellular macromolecules and exerts its cytotoxic effects through a series of biochemical mechanisms by binding to Deoxyribonucleic acid (DNA) and forming intra-strand DNA adducts leading to the inhibition of DNA synthesis and cell growth. Its primary molecular mechanism of action has been associated with the induction of both intrinsic and extrinsic pathways of apoptosis resulting from the production of reactive oxygen species through lipid peroxidation, activation of various signal transduction pathways, induction of p53 signaling and cell cycle arrest, upregulation of pro-apoptotic genes/proteins, and down-regulation of proto-oncogenes and anti-apoptotic genes/proteins. Despite great clinical outcomes, many studies have reported substantial side effects associated with cisplatin monotherapy, while others have shown substantial drug resistance in some cancer patients. Hence, new formulations and several combinational therapies with other drugs have been tested for the purpose of improving the clinical utility of cisplatin. Therefore, this review provides a comprehensive understanding of its molecular mechanisms of action in cancer therapy and discusses the therapeutic approaches to overcome cisplatin resistance and side effects.
103 citations
••
102 citations
••
TL;DR: In this paper, the authors used scanning tunneling microscopy (STM) to study the oxidation of stepped (100) PbS surfaces in air over periods up to 270 min.
102 citations
••
TL;DR: Most research has been conducted within the SWEBOK knowledge areas software engineering process, management, construction, design, and requirements, with the shift of focus towards process and management areas.
102 citations
Authors
Showing all 9016 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marc Humbert | 149 | 1184 | 100577 |
Vladimir N. Uversky | 131 | 959 | 75342 |
Edward L. Deci | 130 | 284 | 206930 |
Andrew J.S. Coats | 127 | 820 | 94490 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Yusuf A. Hannun | 126 | 589 | 62729 |
Anthony Howell | 120 | 714 | 55075 |
David C. Baulcombe | 110 | 287 | 50828 |
Petr Pyšek | 110 | 523 | 54926 |
Allen N. Berger | 106 | 382 | 65596 |
Mark S. George | 106 | 592 | 39480 |
John C. Avise | 105 | 413 | 53088 |
Peter Riederer | 104 | 565 | 42472 |
Xiaodong Li | 104 | 1300 | 49024 |
Stuart J. H. Biddle | 102 | 484 | 41251 |