Technical University of Ostrava

About: Technical University of Ostrava is a education organization based out in Ostrava, Czechia. It is known for research contribution in the topics: Artificial neural network & Evolutionary algorithm. The organization has 4186 authors who have published 8936 publications receiving 65393 citations. The organization is also known as: Vysoká škola báňská – Technická univerzita Ostrava & VŠB – Technical University of Ostrava.

Complex Biomedical System with Mobile Clients

Abstract: Our project deal with the system development of personal sources in area of home care agencies. System consists of the three main parts - PC application, mobile application and database server. All these parts are built on Microsoft .NET solution namely on performances .NET Framework 3.5 and MS SQL server 2008, .NET Compact Framework 3.5 and MS SQL server 3.5 Compact Edition. System works offline, whereas synchronization mobile arrangement with data in database is made only in agency by the help of technology USB, Bluetooth or WiFi. However the system has also the possibility to work in the online mode, allows the interviewing on database by the use of the web services. Software layer synchronization administration data is based on technologies ADO .NET and Linq. System will further develop and will base for advancement biomedical science research framework.

Chitosan-Based Carbon Quantum Dots for Biomedical Applications: Synthesis and Characterization.

Abstract: Rapid development in medicine and pharmacy has created a need for novel biomaterials with advanced properties such as photoluminescence, biocompability and long-term stability. The following research deals with the preparation of novel types of N-doped chitosan-based carbon quantum dots. Nanomaterials were obtained with simultaneous nitrogen-doping using biocompatible amino acids according to Green Chemistry principles. For the carbon quantum dots synthesis chitosan was used as a raw material known for its biocompability. The nanomaterials obtained in the form of lyophilic colloids were characterized by spectroscopic and spectrofluorimetric methods. Their quantum yields were determined. Additionally the cytotoxicity of the prepared bionanomaterials was evaluated by XTT (2,3-Bis-(2-methoxy-4-nitro5-sulfophenyl)-2H-tetrazolium-5-carboxanilide salt) method. Our results confirmed the formation of biocompatible quantum dots with carbon cores exhibiting luminescence in visible range. Performed studies showed that modification with lysine (11.5%) and glutamic acid (7.4%) had a high impact on quantum yield, whereas functionalization with amino acids rich in S and N atoms did not significantly increase in fluorescence properties. XTT assays as well as morphological studies on human dermal fibroblasts confirmed the lack of cytotoxicity of the prepared bionanomaterials. The study shows chitosan-based quantum dots to be promising for biomedical applications such as cell labelling, diagnostics or controlled drug delivery and release systems.