Institution
Tenri University
Education•Tenri, Japan•
About: Tenri University is a education organization based out in Tenri, Japan. It is known for research contribution in the topics: Cartilage & Population. The organization has 55 authors who have published 153 publications receiving 1762 citations.
Topics: Cartilage, Population, Land cover, Soleus muscle, Synovial fluid
Papers published on a yearly basis
Papers
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TL;DR: This review describes the catabolic activities of matrix degradation products, especially fibronectin fragments, and discusses the pathologic implication in cartilage destruction in osteoarthritis and rheumatoid arthritis.
Abstract: The progressive destruction of articular cartilage is one of the hallmarks of osteoarthritis and rheumatoid arthritis. Cartilage degradation is attributed to different classes of catabolic factors, including proinflammatory cytokines, aggrecanases, matrix metalloproteinases, and nitric oxide. Recently, matrix degradation products generated by excessive proteolysis in arthritis have been found to mediate cartilage destruction. These proteolytic fragments activate chondrocytes and synovial fibroblasts via specific cell surface receptors that can stimulate catabolic intracellular signaling pathways, leading to the induction of such catalysts. This review describes the catabolic activities of matrix degradation products, especially fibronectin fragments, and discusses the pathologic implication in cartilage destruction in osteoarthritis and rheumatoid arthritis. Increased levels of these degradation products, found in diseased joints, may stimulate cartilage breakdown by mechanisms of the kind demonstrated in the review.
117 citations
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University of Málaga1, Manchester Metropolitan University2, Center for International Forestry Research3, University College London4, Washington State University Vancouver5, Wildlife Conservation Society6, Roma Tre University7, Tenri University8, Yamaguchi University9, Kyoto University10, University of Florida11, Université du Québec à Montréal12, Centre national de la recherche scientifique13, Durham University14, Hosei University15, CGIAR16
TL;DR: It is argued that fragmentation of the existing Pygmy populations, alongside pressure from extractive industries and sometimes conflict with conservation areas, endanger their future and there is an urgent need to inform policies that can mitigate against future external threats to these indigenous peoples’ culture and lifestyles.
Abstract: Pygmy populations occupy a vast territory extending west-to-east along the central African belt from the Congo Basin to Lake Victoria. However, their numbers and actual distribution is not known precisely. Here, we undertake this task by using locational data and population sizes for an unprecedented number of known Pygmy camps and settlements (n = 654) in five of the nine countries where currently distributed. With these data we develop spatial distribution models based on the favourability function, which distinguish areas with favourable environmental conditions from those less suitable for Pygmy presence. Highly favourable areas were significantly explained by presence of tropical forests, and by lower human pressure variables. For documented Pygmy settlements, we use the relationship between observed population sizes and predicted favourability values to estimate the total Pygmy population throughout Central Africa. We estimate that around 920,000 Pygmies (over 60% in DRC) is possible within favourable forest areas in Central Africa. We argue that fragmentation of the existing Pygmy populations, alongside pressure from extractive industries and sometimes conflict with conservation areas, endanger their future. There is an urgent need to inform policies that can mitigate against future external threats to these indigenous peoples’ culture and lifestyles.
110 citations
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01 Feb 2002TL;DR: In this article, commercial funerals for contemporary Japanese are discussed, including the phase of negated death, rites of passage, and commoditization of the bathing ceremony, and the shift to commercialization and mass consumption.
Abstract: Introduction: commercial funerals for contemporary Japanese 1. Death rituals in anthropology and Japanese folklore studies 2. The history of Japanese funeral traditions 3. The phase of negated death 4. The funeral ceremony: rites of passage 5. Funeral professionals at moon rise 6. Funeral professionals outside of moon rise 7. The commoditization of the bathing ceremony Conclusion: the shift to commercialization and mass consumption Notes Bibliography Index.
90 citations
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TL;DR: It is shown that connective tissue cells contribute to a substantial amount of HO anlagen caused by trauma using postnatal, tamoxifen‐inducible, scleraxis‐lineage restricted reporter mice (Scx‐creERT2/tdTomatofl/fl).
Abstract: The pathologic development of heterotopic ossification (HO) is well described in patients with extensive trauma or with hyperactivating mutations of the bone morphogenetic protein (BMP) receptor ACVR1. However, identification of progenitor cells contributing to this process remains elusive. Here we show that connective tissue cells contribute to a substantial amount of HO anlagen caused by trauma using postnatal, tamoxifen-inducible, scleraxis-lineage restricted reporter mice (Scx-creERT2/tdTomatofl/fl ). When the scleraxis-lineage is restricted specifically to adults prior to injury marked cells contribute to each stage of the developing HO anlagen and coexpress markers of endochondral ossification (Osterix, SOX9). Furthermore, these adult preinjury restricted cells coexpressed mesenchymal stem cell markers including PDGFRα, Sca1, and S100A4 in HO. When constitutively active ACVR1 (caACVR1) was expressed in scx-cre cells in the absence of injury (Scx-cre/caACVR1fl/fl ), tendons and joints formed HO. Postnatal lineage-restricted, tamoxifen-inducible caACVR1 expression (Scx-creERT2/caACVR1fl/fl ) was sufficient to form HO after directed cardiotoxin-induced muscle injury. These findings suggest that cells expressing scleraxis within muscle or tendon contribute to HO in the setting of both trauma or hyperactive BMP receptor (e.g., caACVR1) activity. Stem Cells 2017;35:705-710.
81 citations
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TL;DR: It is unlikely that continuation of intermittent low-dose MTX treatment increases the risk of postoperative complications in patients with RA, and continued treatment with MTX during perioperative period could suppress disease flares, especially in severe RA patients.
Abstract: To determine the potential contribution of inter- mittent low-dose methotrexate (MTX) treatment (2-8 mg/ week) to postoperative complications, we studied 122 pa- tients with rheumatoid arthritis (RA) who had 201 surgical procedures. The patients with treatment with MTX were allocated to two groups: those who continued MTX (group A, 77 procedures) and those who discontinued MTX more than 1 week (group B, 21 procedures). The patients who had no treatment with MTX were allocated to group C (103 procedures). The incidence of postoperative infection, poor wound healing, and flare-up of RA was compared between the three groups. Postoperative infection occurred in 3.9%, 4.8%, and 3.9% in groups A, B, and C, respectively. Poor wound healing was experienced in 1.3%, 9.5%, and 7.8% in groups A, B, and C, respectively. At 4 weeks postopera- tively, 3.9%, 14.3%, and 6.8% of flares were seen in groups A, B, and C, respectively. No significant difference was found in the patients with or without perioperative use of MTX. From these results, it is unlikely that continuation of intermittent low-dose MTX treatment increases the risk of postoperative complications in patients with RA. Contin- ued treatment with MTX during perioperative period could suppress disease flares, especially in severe RA patients.
72 citations
Authors
Showing all 55 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tadashi Yasuda | 29 | 68 | 4473 |
Nobuhiro Kamiya | 28 | 64 | 2652 |
Toshiaki Nakatani | 6 | 15 | 144 |
Kayoko Shikishima-Tsuji | 5 | 14 | 108 |
Shiho Hattori | 5 | 6 | 192 |
Hikaru Suzuki | 5 | 8 | 149 |
Noriko Soyama | 4 | 14 | 59 |
Takanori Sato | 4 | 7 | 96 |
Minoru Itoh | 4 | 6 | 102 |
Katsuhito Uehara | 3 | 9 | 18 |
Kazufumi Terada | 3 | 4 | 19 |
Masaaki Okita | 3 | 5 | 43 |
Hisami Nakamura | 3 | 6 | 40 |
Walter Edwards | 3 | 5 | 31 |
K. Hinotani | 3 | 3 | 31 |