The Hertz Corporation

About: The Hertz Corporation is a based out in . It is known for research contribution in the topics: Population & Soil water. The organization has 9562 authors who have published 11044 publications receiving 447929 citations. The organization is also known as: Hertz Rental Car & Hertz Rent-a-Car.

Gas and vapour movements in the soil: II. The diffusion of carbon dioxide through porous solids

Abstract: Apparatus for measuring the rate of diffusion of carbon dioxide through granular solids is described and the results obtained with it are shown to conform to the curve connecting D/D0 and S previously obtained for carbon disulphide and acetone. The equation D/D0 = 0·66S, which it is suggested should replace Buckingham's equation D/D0=S2, is applied to a discussion of soil aeration, and it is shown that at all porosities the rate of diffusion of carbon dioxide from the soil is sufficient to account for normal respiration without invoking the assistance of meteorological changes. A further application of the equation to water vapour movement in soils is briefly discussed.

Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo

Abstract: Interleukin-6 (IL-6) contributes to increased pain and hyperalgesia in inflamed tissue. We have investigated the effects of IL-6, alone or in combination with its soluble receptor (sIL-6R), on the sensitivity of nociceptors to noxious heat, using dermal microdialysis. Plasmapheresis membranes were inserted into the abdominal skin of adult male Wistar rats ( n =46) and perfused with modified Ringer solution. After three control samples (20 min each), the skin area above the membrane was heated to 48°C for 20 min. The stimulation was followed by two washout samples. The calcitonin gene-related peptide (CGRP) content of the dialysate was measured with an enzyme immunoassay. Heat stimulation provoked a significant CGRP increase in the dialysate. Intradermal application of IL-6 (200 ng ml −1 ) did not significantly alter heat-induced CGRP release. However, a significant sensitisation of the heat-induced CGRP release was observed when sIL-6R (25 ng ml −1 ) was applied, either alone or in combination with IL-6. Neutralisation of endogenous IL-6 with a sheep anti-rat IL-6 serum did not alter heat-induced CGRP release, but abolished the sIL-6R-mediated sensitising effect. We show that IL-6 in combination with its soluble receptor can sensitise nociceptors to heat and provide evidence for the constitutive expression of the signalling molecule gp130, but not of the IL-6-membrane-bound (specific) receptor, in nociceptors.