Institution
Tianjin Medical University
Education•Tianjin, China•
About: Tianjin Medical University is a education organization based out in Tianjin, China. It is known for research contribution in the topics: Cancer & Metastasis. The organization has 19345 authors who have published 13942 publications receiving 241709 citations. The organization is also known as: Tiānjīn Yīkē Dàxué.
Topics: Cancer, Metastasis, Breast cancer, Population, Medicine
Papers published on a yearly basis
Papers
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TL;DR: The results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors.
Abstract: Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADRβ2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors. [BMB Reports 2015; 48(5): 295-300]
82 citations
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TL;DR: It is found that TGF‐β signaling is required for normal growth plate cartilage and endplate cartilage growth at postnatal stage and the expression of Mmp13 gene is significantly up‐regulated in primary disc cells of Tgfbr2 conditional knockout mice.
82 citations
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TL;DR: The authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting DC activation in several preclinical mouse models and provides an avenue to improve DC-based immunotherapy.
Abstract: Treating large established tumors is challenging for dendritic cell (DC)-based immunotherapy. DC activation with tumor cell-derived exosomes (TEXs) carrying multiple tumor-associated antigen can enhance tumor recognition. Adding a potent adjuvant, high mobility group nucleosome-binding protein 1 (HMGN1), boosts DCs' ability to activate T cells and improves vaccine efficiency. Here, we demonstrate that TEXs painted with the functional domain of HMGN1 (TEX-N1ND) via an exosomal anchor peptide potentiates DC immunogenicity. TEX-N1ND pulsed DCs (DCTEX-N1ND) elicit long-lasting antitumor immunity and tumor suppression in different syngeneic mouse models with large tumor burdens, most notably large, poorly immunogenic orthotopic hepatocellular carcinoma (HCC). DCTEX-N1ND show increased homing to lymphoid tissues and contribute to augmented memory T cells. Importantly, N1ND-painted serum exosomes from cancer patients also promote DC activation. Our study demonstrates the potency of TEX-N1ND to strengthen DC immunogenicity and to suppress large established tumors, and thus provides an avenue to improve DC-based immunotherapy.
82 citations
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TL;DR: Data indicate that PTEN may play a role in ischemia/reperfusion injury by inhibiting anti-apoptotic survival signals and inhibitory PTEN inactivation may serve as a potential approach to exert cardiac protection against ischemIA reperfusions injury.
82 citations
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TL;DR: Rational design of chimeric peptides with specific titanium-binding motifs and antimicrobial motifs against bacteria can be optimized by the proper selection of linkers and provides a promising alternative to inhibit the formation of biofilms on titanium surfaces.
Abstract: Bacterial adhesion and biofilm formation are the primary causes of implant-associated infection, which is difficult to eliminate and may induce failure in dental implants. Chimeric peptides with both binding and antimicrobial motifs may provide a promising alternative to inhibit biofilm formation on titanium surfaces. In this study, chimeric peptides were designed by connecting an antimicrobial motif (JH8194: KRLFRRWQWRMKKY) with a binding motif (minTBP-1: RKLPDA) directly or via flexible/rigid linkers to modify Ti surfaces. We evaluated the binding behavior of peptides using quartz crystal microbalance (QCM) and atomic force microscopy (AFM) techniques and investigated the effect of the modification of titanium surfaces with these peptides on the bioactivity of Streptococcus gordonii (S. gordonii) and Streptococcus sanguis (S. sanguis). Compared with the flexible linker (GGGGS), the rigid linker (PAPAP) significantly increased the adsorption of the chimeric peptide on titanium surfaces (p < 0.05). Concen...
82 citations
Authors
Showing all 19408 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Yang | 171 | 2644 | 153049 |
Wei Zheng | 151 | 1929 | 120209 |
Bo Wang | 119 | 2905 | 84863 |
Qian Wang | 108 | 2148 | 65557 |
Yongsheng Chen | 107 | 465 | 55962 |
Jian Zhang | 107 | 3064 | 69715 |
Wei Liu | 102 | 2927 | 65228 |
Bin Zhang | 99 | 435 | 55028 |
Lei Liu | 98 | 2041 | 51163 |
Chawnshang Chang | 97 | 534 | 35629 |
Bin Li | 92 | 1755 | 42835 |
Yihai Cao | 90 | 304 | 32712 |
Chen-Yu Zhang | 85 | 332 | 39724 |
Hsing Jien Kung | 85 | 349 | 30686 |
Susan K. Lutgendorf | 77 | 248 | 17318 |