Institution
Tianjin Medical University
Education•Tianjin, China•
About: Tianjin Medical University is a education organization based out in Tianjin, China. It is known for research contribution in the topics: Cancer & Metastasis. The organization has 19345 authors who have published 13942 publications receiving 241709 citations. The organization is also known as: Tiānjīn Yīkē Dàxué.
Topics: Cancer, Metastasis, Breast cancer, Population, Medicine
Papers published on a yearly basis
Papers
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TL;DR: It is reported that G-coupled receptors in layer II/III of visual cortex control the polarity of synaptic plasticity through a pull-push regulation of LTP and LTD.
104 citations
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Vanderbilt University1, Centers for Disease Control and Prevention2, Seoul National University3, Tianjin Medical University Cancer Institute and Hospital4, Nanjing Medical University5, Academia Sinica6, University of Southern California7, Li Ka Shing Faculty of Medicine, University of Hong Kong8, Sun Yat-sen University9, National Cancer Research Institute10, Tianjin Medical University11, University of Ulsan12, University of Hawaii13, Soonchunhyang University14
TL;DR: The results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women and in vitro electrophoretic mobility shift assays demonstrated the potential functional significance of this SNP.
Abstract: Although approximately 20 common genetic susceptibility loci have been identified for breast cancer risk through genome-wide association studies (GWASs), genetic risk variants reported to date explain only a small fraction of heritability for this common cancer. We conducted a four-stage GWAS including 17 153 cases and 16 943 controls among East-Asian women to search for new genetic risk factors for breast cancer. After analyzing 684 457 SNPs in 2062 cases and 2066 controls (Stage I), we selected for replication among 5969 Chinese women (4146 cases and 1823 controls) the top 49 SNPs that had neither been reported previously nor were in strong linkage disequilibrium with reported SNPs (Stage II). Three SNPs were further evaluated in up to 13 152 Chinese and Japanese women (6436 cases and 6716 controls) (Stage III). Finally, two SNPs were evaluated in 10 847 Korean women (4509 cases and 6338 controls) (Stage IV). SNP rs10822013 on chromosome 10q21.2, located in the zinc finger protein 365 (ZNF365) gene, showed a consistent association with breast cancer risk in all four stages with a combined per-risk allele odds ratio of 1.10 (95% CI: 1.07-1.14) (P-value for trend = 5.87 × 10(-9)). In vitro electrophoretic mobility shift assays demonstrated the potential functional significance of rs10822013. Our results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women.
104 citations
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TL;DR: It is concluded that miR‐20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.
104 citations
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TL;DR: A novel method to synthesize biocompatible CuS nanoparticles for photothermal therapy using bovine serum albumin (BSA) as a template via mimicking biomaterialization processes is reported, showing great potential as an ideal photothermal agent for cancer treatment.
Abstract: Photothermal therapy as a physical therapeutic approach has greatly attracted research interest due to its negligible systemic effects. Among the various photothermal agents, CuS nanoparticles have been widely used due to their easy preparation, low cost, high stability and strong absorption in the NIR region. However, the ambiguous biotoxicity of CuS nanoparticles limited their bio-application. So it is highly desirable to develop biocompatible CuS photothermal agents with the potential of clinical translation. Herein, we report a novel method to synthesize biocompatible CuS nanoparticles for photothermal therapy using bovine serum albumin (BSA) as a template via mimicking biomaterialization processes. Owing to the inherent biocompatibility of BSA, the toxicity assays in vitro and in vivo showed that BSA–CuS nanoparticles possessed good biocompatibility. In vitro and in vivo photothermal therapies were performed and good results were obtained. The bulk of the HeLa cells treated with BSA–CuS nanoparticles under laser irradiation (808 nm) were killed, and the tumor tissues of mice were also successfully eliminated without causing any obvious systemic damage. In summary, a novel strategy for the synthesis of CuS nanoparticles was developed using BSA as the template, and the excellent biocompatibility and efficient photothermal therapy effects of BSA–CuS nanoparticles show great potential as an ideal photothermal agent for cancer treatment.
104 citations
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TL;DR: This drug carrier system has significant liver-targeting property and exhibits advantages for the combination therapy against hepatocellular carcinoma.
104 citations
Authors
Showing all 19408 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Yang | 171 | 2644 | 153049 |
Wei Zheng | 151 | 1929 | 120209 |
Bo Wang | 119 | 2905 | 84863 |
Qian Wang | 108 | 2148 | 65557 |
Yongsheng Chen | 107 | 465 | 55962 |
Jian Zhang | 107 | 3064 | 69715 |
Wei Liu | 102 | 2927 | 65228 |
Bin Zhang | 99 | 435 | 55028 |
Lei Liu | 98 | 2041 | 51163 |
Chawnshang Chang | 97 | 534 | 35629 |
Bin Li | 92 | 1755 | 42835 |
Yihai Cao | 90 | 304 | 32712 |
Chen-Yu Zhang | 85 | 332 | 39724 |
Hsing Jien Kung | 85 | 349 | 30686 |
Susan K. Lutgendorf | 77 | 248 | 17318 |