United Arab Emirates University

About: United Arab Emirates University is a education organization based out in Al Ain, United Arab Emirates. It is known for research contribution in the topics: Population & Diabetes mellitus. The organization has 6227 authors who have published 14170 publications receiving 321143 citations. The organization is also known as: University of the United Arab Emirates & UAEU.

Titans of the early Universe: The Prato statement on the origin of the first supermassive black holes

Abstract: In recent years, the discovery of massive quasars at has provided a striking challenge to our understanding of the origin and growth of supermassive black holes in the early Universe. Mounting observational and theoretical evidence indicates the viability of massive seeds, formed by the collapse of supermassive stars, as a progenitor model for such early, massive accreting black holes. Although considerable progress has been made in our theoretical understanding, many questions remain regarding how (and how often) such objects may form, how they live and die, and how next generation observatories may yield new insight into the origin of these primordial titans. This review focusses on our present understanding of this remarkable formation scenario, based on the discussions held at the Monash Prato Centre from November 20 to 24, 2017, during the workshop ‘Titans of the Early Universe: The Origin of the First Supermassive Black Holes’.

IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin

Abstract: IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell damage and the development of diabetes, as evaluated by blood glucose, quantitative histology, immunohistochemistry and expression of relevant cytokines in the islets. Ten daily injections of 400 ng IL-23, starting on the first day of MLD-STZ administration led to significant and sustained hyperglycemia along with weight loss compared with controls (no IL-23), and a significant increase in the number of infiltrating cells, a lower insulin content, enhanced apoptosis, expression of IFN-gamma and IL-17 (not seen in the controls) and a significant increase in the expression of TNF-alpha and IL-18 in the pancreatic islets. IL-23 treatment started 5 days prior to MLD-STZ administration had no effect on diabetogenesis or cytokines expression in the pancreatic islets. We provide the first evidence in an animal model that IL-23 is involved in the development of type-1 diabetes, by inducing IL-17 and possibly IFN-gamma production in the target tissue.

A survey on service-oriented middleware for wireless sensor networks

Abstract: Wireless sensor networks (WSN) are used for many applications such as environmental monitoring, infrastructure security, healthcare applications, and traffic control. The design and development of such applications must address many challenges dictated by WSN characteristics on one hand and the targeted applications on the other. One of the emerging approaches used for relaxing these challenges is using service-oriented middleware (SOM). Service-oriented computing, in general, aims to make services available and easily accessible through standardized models and protocols without having to worry about the underlying infrastructures, development models, or implementation details. SOM could play an important role in facilitating the design, development, and implementation of service-oriented systems. This will help achieve interoperability, loose coupling, and heterogeneity support. Furthermore, SOM approaches will provision non-functional requirements like scalability, reliability, flexibility, and Quality of Service (QoS) assurance. This paper surveys the current work in SOM and the trends and challenges to be addressed when designing and developing these solutions for WSN.