Institution
United Arab Emirates University
Education•Al Ain, United Arab Emirates•
About: United Arab Emirates University is a education organization based out in Al Ain, United Arab Emirates. It is known for research contribution in the topics: Population & Diabetes mellitus. The organization has 6227 authors who have published 14170 publications receiving 321143 citations. The organization is also known as: University of the United Arab Emirates & UAEU.
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Papers
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TL;DR: Oral curcumin reversed the alterations in the plasma neurotensin and sciatic nerve platinum concentrations, and markedly improved Sciatic nerve histology in the platinum-treated rats, reports the possible protective effect of curcuming on some cisplatin- and oxali Platin-induced behavioral, biochemical, and histopathological alterations in rats.
Abstract: Cisplatin is commonly used against several solid tumors, and oxaliplatin is an effective cytotoxic drug used in colorectal cancer. A major clinical issue affecting 10–40 % of patients treated with cisplatin or oxaliplatin is severe peripheral neuropathy causing sensory, motor, and autonomic dysfunction, with symptoms including cold sensitivity and neuropathic pain. The biochemical basis of the neurotoxicity is uncertain, but is associated with oxidative stress. Curcumin (a natural phenolic yellow pigment) has strong antioxidant, anticancer, and anti-inflammatory actions. Here we report the possible protective effect of curcumin on some cisplatin- and oxaliplatin-induced behavioral, biochemical, and histopathological alterations in rats. Twenty-four hours after the end of treatments some motor and behavioral tests (motor activity, thermal and mechanical nociception, and neuromuscular coordination) were conducted, followed by measuring plasma neurotensin platinum concentration in the sciatic nerve, and studying the histopathology of the sciatic nerve. Oxaliplatin (4 mg/kg) and cisplatin (2 mg/kg) [each given twice weekly, in a total of nine intraperitoneal injections over 4.5 weeks] significantly increased plasma neurotensin concentration, caused specific damage in the histology of the sciatic nerve and produced variable effects in the motor and behavioral tests. Oral curcumin (10 mg/kg, 4 days before the platinum drug, and thereafter, concomitantly with it for 4.5 weeks) reversed the alterations in the plasma neurotensin and sciatic nerve platinum concentrations, and markedly improved sciatic nerve histology in the platinum-treated rats. Larger experiments using a wider dose range of oxaliplatin, cisplatin, and curcumin are required to fully elucidate the possible protective role of curcumin in platinum-induced neurotoxicity.
106 citations
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TL;DR: The data suggest that protease inhibitors in skin secretions may play a role complementary to cationic, amphipathic alpha-helical peptides in protecting anurans from invasions by microorganisms.
106 citations
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TL;DR: In this paper, a simplified thermodynamics analytical model for steady airflow inside a solar chimney is performed, where a simplified Bernoulli equation combined with fluid statics and ideal gas equation was implemented and solved using EES solver to predict the performance of the solar ch chimney power plant.
106 citations
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TL;DR: In this paper, the authors examined antecedents of trust formation in new product development (NPD) teams and the effects of trust on NPD team performance, including task complexity as a moderating variable.
106 citations
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TL;DR: Data show that USUV has managed to overwinter and has been able to establish a transmission cycle in Austria, the virus seems to have become a resident pathogen of Austria with a tendency to spread to other geographic areas, and the surveillance of dead blackbirds is a useful sentinel system for monitoring USUV activity.
105 citations
Authors
Showing all 6340 results
Name | H-index | Papers | Citations |
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Vijay P. Singh | 106 | 1699 | 55831 |
Peter H.R. Green | 106 | 843 | 60113 |
Muhammad Imran | 94 | 3053 | 51728 |
Soottawat Benjakul | 92 | 891 | 34336 |
André Reis | 85 | 439 | 30225 |
Vicki H. Grassian | 80 | 390 | 22057 |
Ibrahim M. Banat | 78 | 325 | 26063 |
Muhammad Iqbal | 77 | 961 | 23821 |
Valérie Cormier-Daire | 77 | 439 | 21366 |
Nidal Hilal | 72 | 395 | 21524 |
Magdy M. A. Salama | 67 | 517 | 20313 |
Muhammad Tahir | 65 | 1636 | 23892 |
Shaher Momani | 64 | 301 | 13680 |
Timothy G. Yandle | 63 | 206 | 15705 |
Tewodros Asefa | 62 | 224 | 23741 |