University Dental Hospital of Manchester

About: University Dental Hospital of Manchester is a healthcare organization based out in Manchester, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 584 authors who have published 939 publications receiving 30811 citations.

The radiological prediction of inferior alveolar nerve injury during third molar surgery.

Abstract: The surgical removal of an impacted mandibular third molar may result in damage to the inferior alveolar nerve and may cause disabling anaesthesia of the lip; anaesthesia of the lower gingivae and anterior teeth may also result Assessing the likelihood of injury depends to a great extent on preoperative radiographic examination Seven radiological diagnostic signs have been mentioned in the literature; the reliability of these signs as predictors of likely nerve injury have been evaluated through retrospective and prospective surveys Three signs were found to be significantly related to nerve injury and a further two were probably important clinically

Dietary fat intake and prevention of cardiovascular disease: systematic review.

Abstract: Objective To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity. Design Systematic review. Data sources Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included. Included studies Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta›analysis (random effects methodology), meta›regression, and funnel plots were performed. Results 27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years’ follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90). Conclusions There is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.

The Eurocleft project 1996-2000: overview.

Abstract: Introduction: The original Eurocleft project, a European intercentre comparison study, revealed dramatic differences in outcome, which were a powerful stimulus for improvement in the services of respective teams. The study developed a preliminary methodology to compare practices and the potential for wider European collaboration including opportunities for the promotion of clinical trials and intercentre comparison was recognized by the European Commission. Therefore, the project: ‘Standards of Care for Cleft Lip and Palate in Europe: Eurocleft’ ran between 1996 and 2000 and aimed to promote a broad uplift in the quality of care and research in the area of cleft lip and palate. Results: The results of the 1996–2000 project include: • a register of services in Europe, with details of professionals and teams involved in cleft care, service organization, clinical protocols and special facilities for research; • a set of common Policy Statements governing clinical practice for European cleft teams, Practice Guidelines describing minimum recommendations for care that all European children with clefts should be entitled to and recommendations for Documentation governing minimum records that cleft teams should maintain; • encouraging initial efforts to compare outcomes (results) of care between centres. A survey showed a wide diversity in models of care and national policies as well as clinical practices in Europe. Of the 201 centres that registered with the network, the survey showed 194 different protocols being followed for only unilateral clefts. Conclusion: Cleft services, treatment and research have undoubtedly suffered from haphazard development across Europe. Attainment of even minimum standards of care remains a major challenge in some communities and both the will to reform and a basic strategy to follow are overdue. It is hoped that the Eurocleft Consensus Recommendations reached during the present project will assist in improving the opportunities for tomorrow's patients. It is also hoped that the collaborative research now beginning under the European Commission's Framework V Programme will provide a focus for European researchers wishing to improve understanding, treatment and prevention of clefts of the lip, alveolus and palate in the years ahead.