Institution
University of Catania
Education•Catania, Italy•
About: University of Catania is a education organization based out in Catania, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 14599 authors who have published 41195 publications receiving 1032705 citations. The organization is also known as: Università degli Studi di Catania & Universita degli Studi di Catania.
Papers published on a yearly basis
Papers
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TL;DR: Results indicate that MPEP and CPCCOEt bind to overlapping binding pockets in the TM region of group I mGluRs but interact with different non-conserved residues.
271 citations
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11 Jul 2013
TL;DR: In this paper, the ALICE detector was used to measure the long-range correlations between trigger particles and various species of charged associated particles (unidentified particles, pions, kaons, protons and antiprotons).
Abstract: Angular correlations between unidentified charged trigger particles and various species of charged associated particles (unidentified particles, pions, kaons, protons and antiprotons) are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV in the transverse-momentum range 0.3 < p(T) < 4 GeV/c. The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range vertical bar n(lab)vertical bar < 0.8. Fourier coefficients are extracted from the long-range correlations projected onto the azimuthal angle difference and studied as a function of p(T) and in intervals of event multiplicity. In high-multiplicity events, the second-order coefficient for protons, 4, is observed to be smaller than that for pions, v(2)(pi), up to about p(T) = 2 GeV/c. To reduce correlations due to jets, the per-trigger yield measured in low-multiplicity events is subtracted from that in high-multiplicity events. A two-ridge structure is obtained for all particle species. The Fourier decomposition of this structure shows that the second-order coefficients for pions and kaons are similar. The v(2)(p) is found to be smaller at low P-T and larger at higher p(T) than v(2)(pi), with a crossing occurring at about 2 GeV/c. This is qualitatively similar to the elliptic-flow pattern observed in heavy-ion collisions. A mass ordering effect at low transverse momenta is consistent with expectations from hydrodynamic model calculations assuming a collectively expanding system. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved.
271 citations
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TL;DR: The mechanism of uptake and translocation of MPs can be the same described and reported for carbon-nanomaterials and this may be a possible translocation route of MPs by environment to vegetables permitting, so, the translocation or uptake inside of their biological systems.
271 citations
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TL;DR: One-and-one-half-bound (OOHB) as discussed by the authors was proposed to reduce the potential for response bias on the follow-up bid in multiple-bound discrete choice CVM questions.
Abstract: To reduce the potential for response bias on the follow-up bid in multiple-bound discrete choice CVM questions while maintaining much of the efficiency gains of the multiple-bound approach, we introduce the one-and-one-half-bound (OOHB) approach. Despite the fact that the OOHB model uses less information than the double-bound (DB) approach, efficiency gains in moving from single-bound to OOHB capture a large portion of the gain associated with moving from single-bound to DB. In an analysis of survey data, our OOHB estimates demonstrated higher consistency with respect to the follow-up data than the DB estimates and were more efficient as well.
270 citations
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TL;DR: Hybrid-Rs are present and play a major role in mediating the IGF-I signal in breast cancer; their expression is directly related to IR overexpression; and potential therapies designed to block IGF- I actions in breast cancers must take into account the role of these Hybrid-Rs.
Abstract: The insulin receptor (IR) form hybrids with the closely related insulin-like growth factor-I (IGF-I) receptor (IGF-I-R). Because most human breast carcinomas overexpress both the IR and the IGF-I-R, we evaluated whether the insulin/IGF-I hybrid receptor (Hybrid-R) is also overexpressed in these tumors and what role it plays in breast cancer biology. Using specific ELISAs and Western blots, we measured Hybrid-R content and function in 8 human cultured breast cancer cell lines and 39 human breast cancer specimens. Hybrid-R content and function were also compared to the content and function of the IR and the IGF-I-R. Hybrid-R content exceeded the IGF-I-R content in >75% of breast cancer specimens and was directly related to the molar ratio of both the IR and IGF-I-R content, suggesting that Hybrid-R formation occurred by random assembly of IR and IGF-I-R half-receptors. Hybrid-Rs became tyrosine autophosphorylated when breast cancer cells were exposed to IGF-I but not when they were exposed to insulin. In cells with an elevated Hybrid-R content, Hybrid-R autophosphorylation in response to IGF-I exceeded IGF-I-R autophosphorylation, suggesting that most of the IGF-I effect occurred via the Hybrid-R. Furthermore, Hybrid-Rs mediated growth in response to IGF-I, as indicated by experiments with blocking antibodies to the IGF-I-R. These data indicated therefore that: (a) Hybrid-Rs are present and play a major role in mediating the IGF-I signal in breast cancer; (b) their expression is directly related to IR overexpression; and (c) potential therapies designed to block IGF-I actions in breast cancer must take into account the role of these Hybrid-Rs.
270 citations
Authors
Showing all 14771 results
Name | H-index | Papers | Citations |
---|---|---|---|
Napoleone Ferrara | 167 | 494 | 140647 |
Tobin J. Marks | 159 | 1621 | 111604 |
Susan O'Brien | 145 | 1509 | 87813 |
Stephen T. Holgate | 142 | 870 | 82345 |
Y. Choi | 141 | 1631 | 98709 |
Michael J. Keating | 140 | 1169 | 76353 |
Tiziano Rovelli | 135 | 1441 | 90518 |
Francesco Navarria | 135 | 1535 | 91427 |
Francesca Romana Cavallo | 135 | 1571 | 92392 |
Alessia Tricomi | 133 | 1446 | 92375 |
Burak Bilki | 132 | 1227 | 83478 |
Andrea Castro | 132 | 1500 | 90019 |
Paolo Capiluppi | 131 | 1544 | 89643 |
Daniele Bonacorsi | 130 | 1381 | 85994 |
Vitaliano Ciulli | 129 | 1171 | 82045 |