Institution
University of Catania
Education•Catania, Italy•
About: University of Catania is a education organization based out in Catania, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 14599 authors who have published 41195 publications receiving 1032705 citations. The organization is also known as: Università degli Studi di Catania & Universita degli Studi di Catania.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The bioflavonoids under examination showed a dose-dependent free-radical scavenging effect, a significant inhibition of xanthine oxidase activity, and an antilipoperoxidative capacity, and showed a protective effect on DNA cleavage.
Abstract: Flavonoids have recently aroused considerable interest because of their broad pharmacological activity. In fact, flavonoids have been reported to have antiviral, antiallergic, antiplatelet, anti-inflammatory and antitumoral activities. The pharmacological properties of bioflavonoids have been ascribed both to the concomitant inhibition of enzymes involved in the production of free radicals and to their free-radical scavenging and iron chelating capacity. However the antioxidant capacity of bioflavonoids due to free-radical scavenging and/or to iron chelating is still controversial. In this study, we have investigated the free-radical scavenging capacity of bioflavonoids (rutin, catechin, and naringin). In addition, the effects of these polyphenols on xanthine oxidase activity, spontaneous lipid peroxidation, and DNA cleavage were investigated. The bioflavonoids under examination showed a dose-dependent free-radical scavenging effect, a significant inhibition of xanthine oxidase activity, and an antilipoperoxidative capacity. In addition, they showed a protective effect on DNA cleavage.
333 citations
••
TL;DR: Among patients with NMOSD, satralizumab added to immunosuppressant treatment led to a lower risk of relapse than placebo but did not differ from placebo in its effect on pain or fatigue.
Abstract: Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system and is associated with autoantibodies to anti–aquaporin-4 (AQP4-IgG) in app...
333 citations
••
TL;DR: A thorough review of possible risks of spinosad and novel spinosyns (such as spinetoram) to beneficial arthropods (notably natural enemies and pollinators) is provided, and the acute lethal effect and multiple sublethal effects have been identified in almost all arthropod groups studied.
Abstract: Spinosyn-based products, mostly spinosad, have been widely recommended by extension specialists and agribusiness companies; consequently, they have been used to control various pests in many different cropping systems. Following the worldwide adoption of spinosad-based products for integrated and organic farming, an increasing number of ecotoxicological studies have been published in the past 10 years. These studies are primarily related to the risk assessment of spinosad towards beneficial arthropods. This review takes into account recent data with the aim of (i) highlighting potentially adverse effects of spinosyns on beneficial arthropods (and hence on ecosystem services that they provide in agroecosystems), (ii) clarifying the range of methods used to address spinosyn side effects on biocontrol agents and pollinators in order to provide new insights for the development of more accurate bioassays, (iii) identifying pitfalls when analysing laboratory results to assess field risks and (iv) gaining increasing knowledge on side effects when using spinosad for integrated pest management (IPM) programmes and organic farming. For the first time, a thorough review of possible risks of spinosad and novel spinosyns (such as spinetoram) to beneficial arthropods (notably natural enemies and pollinators) is provided. The acute lethal effect and multiple sublethal effects have been identified in almost all arthropod groups studied. This review will help to optimise the future use of spinosad and new spinosyns in IPM programmes and for organic farming, notably by preventing the possible side effects of spinosyns on beneficial arthropods.
332 citations
••
Newcastle University1, Vita-Salute San Raffaele University2, British Heart Foundation3, Hospital Clínico San Carlos4, Radboud University Nijmegen5, University of Paris6, VU University Medical Center7, National Institutes of Health8, Ludwig Maximilian University of Munich9, Yale University10, St Bartholomew's Hospital11, Brown University12, Autonomous University of Barcelona13, Erasmus University Rotterdam14, Mount Sinai Hospital15, University of Catania16, Queen Mary University of London17
TL;DR: This consensus document provides a definition of INOCA and guidance to the community on the diagnostic approach and management of IN OCA based on existing evidence from research and best available clinical practice; noting gaps in knowledge and potential areas for further investigation.
Abstract: This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA) Angina pectoris affects approximately 112 million people globally Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms INOCA patients present with a wide spectrum of symptoms and signs that are often misdiagnosed as non-cardiac leading to under-diagnosis/investigation and under-treatment INOCA can result from heterogeneous mechanism including coronary vasospasm and microvascular dysfunction and is not a benign condition Compared to asymptomatic individuals, INOCA is associated with increased incidence of cardiovascular events, repeated hospital admissions, as well as impaired quality of life and associated increased health care costs This consensus document provides a definition of INOCA and guidance to the community on the diagnostic approach and management of INOCA based on existing evidence from research and best available clinical practice; noting gaps in knowledge and potential areas for further investigation
331 citations
••
TL;DR: The classification of 105 PAH mutations may allow the prediction of the biochemical phenotype in >10,000 genotypes, which may be useful for the management of hyperphenylalaninemia in newborns.
Abstract: Phenylketonuria (PKU) and mild hyperphenylalaninemia (MHP) are allelic disorders caused by mutations in the gene encoding phenylalanine hydroxylase (PAH). Previous studies have suggested that the highly variable metabolic phenotypes of PAH deficiency correlate with PAH genotypes. We identified both causative mutations in 686 patients from seven European centers. On the basis of the phenotypic characteristics of 297 functionally hemizygous patients, 105 of the mutations were assigned to one of four arbitrary phenotype categories. We proposed and tested a simple model for correlation between genotype and phenotypic outcome. The observed phenotype matched the predicted phenotype in 79% of the cases, and in only 5 of 184 patients was the observed phenotype more than one category away from that expected. Among the seven contributing centers, the proportion of patients for whom the observed phenotype did not match the predicted phenotype was 4%-23% (P 10,000 genotypes, which may be useful for the management of hyperphenylalaninemia in newborns.
330 citations
Authors
Showing all 14771 results
Name | H-index | Papers | Citations |
---|---|---|---|
Napoleone Ferrara | 167 | 494 | 140647 |
Tobin J. Marks | 159 | 1621 | 111604 |
Susan O'Brien | 145 | 1509 | 87813 |
Stephen T. Holgate | 142 | 870 | 82345 |
Y. Choi | 141 | 1631 | 98709 |
Michael J. Keating | 140 | 1169 | 76353 |
Tiziano Rovelli | 135 | 1441 | 90518 |
Francesco Navarria | 135 | 1535 | 91427 |
Francesca Romana Cavallo | 135 | 1571 | 92392 |
Alessia Tricomi | 133 | 1446 | 92375 |
Burak Bilki | 132 | 1227 | 83478 |
Andrea Castro | 132 | 1500 | 90019 |
Paolo Capiluppi | 131 | 1544 | 89643 |
Daniele Bonacorsi | 130 | 1381 | 85994 |
Vitaliano Ciulli | 129 | 1171 | 82045 |