Showing papers by "University of Rajasthan published in 1994"
TL;DR: Of the nine biological trace elements, zinc, copper and selenium are important in reproduction in males and females and the level of testosterone in the male has been suggested to play a role in the severity of copper deficiency.
Abstract: Of the nine biological trace elements, zinc, copper and selenium are important in reproduction in males and females. Zinc content is high in the adult testis, and the prostate has a higher concentration of zinc than any other organ of the body. Zinc deficiency first impairs angiotensin converting enzyme (ACE) activity, and this in turn leads to depletion of testosterone and inhibition of spermatogenesis. Defects in spermatozoa are frequently observed in the zinc-deficient rat. Zinc is thought to help to extend the functional life span of the ejaculated spermatozoa. Zinc deficiency in the female can lead to such problems as impaired synthesis/secretion-of (FSH) and (LH), abnormal ovarian development, disruption of the estrous cycle, frequent abortion, a prolonged gestation period, teratogenicity, still-births, difficulty in parturition, pre-eclampsia, toxemia and low birth weights of infants. The level of testosterone in the male has been suggested to play a role in the severity of copper deficiency. Copper-deficient female rats are protected against mortality due to copper deficiency, and the protection has been suggested to be provided by estrogens, since estrogens alter the subcellular distribution of copper in the liver and increase plasma copper levels by inducing ceruloplasmin synthesis. The selenium content of male gonads increases during pubertal maturation. Selenium is localized in the mitochondrial capsule protein (MCP) of the midpiece. Maximal incorporation in MCP occurs at steps 7 and 12 of spermatogenesis and uptake dereases by step 15. Selenium deficiency in females results in infertility, abortions and retention of the placenta. The newborns from a selenium-deficient mother suffer from muscular weakness, but the concentration of selenium during pregnancy does not have any effect on the weight of the baby or length of pregnancy. The selenium requirements of a pregnant and lactating mother are increased as a result of selenium transport to the fetus via the placenta and to the infant via breast milk.
358 citations
TL;DR: The data revealed that reversible sterility could be induced in male rats by papaya seeds aqueous extract treatment without adverse effects on libido and toxicological profile.
Abstract: The influence of the crude aqueous extract of Carica papaya L. (Caricaceae) seeds has been studied on semen profile, fertility, body and organ weight response, and toxicology in male albino rats. The extract was administered at the dose regimens of 10 and 50 mg/animal/day orally for 30, 60, and 90 days and 0.1 and 1.0 mg/animal/day intramuscularly for 15 and 30 days. Cauda epididymal sperm motility and count was reduced significantly at low and high dose regimens both in the oral as well as the intramuscular groups. The reduced sperm motility was associated with morphological defects. Testicular sperm counts were also reduced in all the treatment groups except the low dose intramuscular group. Fertility tests showed dose- and duration-dependent reduction and zero fertility was observed at high dose regimens of the oral and intramuscular groups following 60 and 30 days of treatment, respectively. Testicular weight was reduced in all the treatment groups, whereas accessory sex organs showed a variable response. Body weight and toxicological observations did not show any untoward response. Fertility and all other associated changes returned to normal within 45 and 30 days of treatment cessation in the oral and intramuscular groups, respectively. The data revealed that reversible sterility could be induced in male rats by papaya seeds aqueous extract treatment without adverse effects on libido and toxicological profile.
85 citations
TL;DR: In this paper, the oblique propagation of ion-acoustic solitons in a magnetized low-β plasma consisting of warm positive and negative ion species along with hot electrons is studied.
Abstract: Oblique propagation of ion-acoustic solitons in a magnetized low-β plasma consisting of warm positive and negative ion species along with hot electrons is studied. Using the reductive perturbation method, a KdV equation is derived for the system, which admits an obliquely propagating soliton solution. It is found that if the ions have finite temperatures then there exist two types of modes, namely slow and fast ion-acoustic modes. The parameter determining the nature of soliton (i.e. whether the system will support compressive or rarefactive solitons) is different for slow and fast modes. For the slow mode the parameter is the relative temperature of the two ion species, whereas for the fast mode it is the relative concentraion of the two ion species. For the fast mode it is found that there is a critical value of the negative-ion concentration below which only compressive solitons exist and above which rarefactive solitons exist. To discuss the soliton solution at the critical concentration, a modified KdV equation is derived. It is found that- at the critical concentration of negative ions compressive and rarefactive solitons co-exist. The effects of temperature of different ion species, angle of obliqueness and magnetization on the characteristics of the solitons are discussed in detail
55 citations
Journal Article•
TL;DR: Inhibition of spermatogenesis indicates for decreased zinc levels in 3-week whereas the increase in 6-week experiment indicates for accumulation of zinc in oedomatous fluid and uncontrolled diffusion of zinc across the blood testis barrier.
Abstract: Zinc, protein, cholesterol, phospholipids, alkaline phosphatase (AlPase), acid phosphatase (AcPase), adenosine-5-triphosphatase(ATPase) and histology were studied in testis of zinc-deficient mice. Zinc and protein decreased in the 3-week experiment whereas they increased in the 6-week experiment. Zinc is involved in several functions of the cell and is regulated by hormones. Inhibition of spermatogenesis indicates for decreased zinc levels in 3-week whereas the increase in 6-week experiment indicates for accumulation of zinc in oedomatous fluid and uncontrolled diffusion of zinc across the blood testis barrier. Glycogen decreased in the 3-week as well as 6-week experiments due to blockage of androgen and spermatogenesis. Cholesterol and phospholipids increased in the 3-week experiment and decreased in 6-week experiment as both the parameters are related to steroidogenesis. Zinc deficiency leads to aspermatogenic condition and comparatively less injury to non-germinal cells. This could have blocked the transport of material across the testis barrier and therefore might have increased AlPase levels. Increased AcPase, probably represents lysosomal enzymes, as the cell debris of disorganised epithelium are to be digested and removed. ATPase increased in 3-week experiment and can be correlated to increased demands of energy of testicular cells to overcome the insults of zinc deficiency whereas the decrease in 6-week experiment could be as a result of inhibition of spermatogenesis.
54 citations
TL;DR: The chemopreventive property of an ethanollc extract of the leaves of Ocimum sanctum (a traditional medicinal plant) on 7,12-dlmethylbenz[a]anthracene Induced skin papillomagenesis In male Swiss albino mice is reported.
Abstract: We report the chemopreventive property of an ethanollc extract of the leaves of Ocimum sanctum (a traditional medicinal plant) on 7,12-dlmethylbenz[a]anthracene Induced skin papillomagenesis In male Swiss albino mice. A significant reduction In the values of tumor Incidence, average number of tumors
48 citations
39 citations
TL;DR: In this paper, a general expression for porosity correction has been derived for diverse two-phase systems from experimental results reported in the literature, and the correction term is found to be dependent on the ratio of thermal conductivities of the constituent phases of the system.
Abstract: Two-phase systems are assumed to contain spherical particles arranged in a three-dimensional cubic array. A general expression for porosity correction has been derived for diverse two-phase systems from experimental results reported in the literature. The correction term is found to be dependent on the ratio of thermal conductivities of the constituent phases of the system and gives better agreement of predicted effective thermal conductivity values with experimental results.
25 citations
TL;DR: In this paper, a first order ferromagnetic transition at T c ≈ 180 K and a reentrant spin glass transition at t g ≈ 125 K was investigated with dc-magnetisation and ac-susceptibility measurements.
19 citations
TL;DR: In this article, the effects of variations in the density and temperature ratios of the two electron species, the ion temperature, the angle of obliqueness and the magnetization on the characteristics of the cnoidal wave are discussed in detail.
Abstract: Obliquely propagating ion-acoustic nonlinear periodic waves in a magnetized plasma consisting of warm adiabatic ions and two Maxwellian electron species are studied. Using the reductive perturbation method, the Korteweg–de Vries (KdV) equation is derived and its cnoidal wave solution is discussed. It is found that as the amplitude of the cnoidal wave increases, so does its frequency. The effects of variations in the density and temperature ratios of the two electron species, the ion temperature, the angle of obliqueness and the magnetization on the characteristics of the cnoidal wave are discussed in detail. When the coefficient of the nonlinear term of the KdV equation, a1, vanishes, the modified Korteweg–de Vries equation is derived, and its periodic-wave solutions are discussed in detail. In the limiting case these periodic-wave solutions reduce to soliton or double-layer solutions.
18 citations
TL;DR: In this article, the stoichiometric formulae [Fe{S2P(OPr-n)2}3] and [S2PO2G}3 ] are precipitated from the reactions of FeCl3 with ammonium dithiophosphates in water.
Abstract: Solids of the stoichiometric formulae [Fe{S2P(OPr-n)2}3] and [Fe{S2PO2G}3] (G = —CH2CMe2CH2—, CMe2−CMe2— or —CH2CH2CHMe—) are precipitated from the reactions of FeCl3 with ammonium dithiophosphates in water. Soluble complexes of the type [Fe{S2PO2G}2], formed by the reactions of FeCl2 with NH4[{S2PO2G}] in MeOH, can be extracted with benzene. Adducts of the types [Fe{S2PO2G}2L] and [Fe{S2PO2G}2(PPh3)2] are formed by the reaction of [Fe{S2PO2G}2] with L (L = 2,2′-bipyridyl or 1,10-phenanthroline) and PPh3, respectively. All the compounds have been characterized by i.r. and u.v.-vis. spectroscopy and magnetic studies.
17 citations
TL;DR: In this article, the synthesis of trimethylaminoborane dithiophosphates of the types B[S2P(OR)2]3.NMe3 and B[ S2POGO]3.
Abstract: O,O'-Dialkyl (or alkylene) dithiophosphates of trimethylaminoborane of the types B[S2P(OR)2]3.NMe3 and B[S2POGO]3.NMe3 (where R = Me, Et, Pri, Bui, Ph; G = -CMe2CMe2- and -CH2CMe2CH2-) have been synthesized as monomeric, white crystalline solids, soluble in common organic solvents and are characterized by elemental analyses, molecular weight measurements, IR and multinuclear (1H, 11B and 31P) NMR spectral studies which are consistent with four coordinated boron and the monodentate behaviour of the dithiophosphate moiety.
TL;DR: In this paper, the P[sbnd]C3 bond of the azaphosphole ring was used to give the zwitterionic 4,5-dihydrooxazolio phosphinate 3.
Abstract: 2-Ethyl-3-phenacyl-4,5-dihydrooxazolium bromide 1 enolizes spontaneously in dimethyl sulfoxide solution. Condensation with phosphorus trichloride nevertheless involves both the methylene groups in 2-and 3-position and thus yields a five-membered ring. Hydrolysis of the resulting 1-methyl-3-benzoyl-5,6-dihydro-1,3-azaphospholo[5,1-b]oxazole 2 selectively opens the P[sbnd]C3 bond of the azaphosphole ring to give the zwitterionic 4,5-dihydrooxazolio phosphinate 3.
TL;DR: In this article, the preparation, characterisation and biological activities of some oxovanadium(V) and manganese(II) complexes of ligands having nitrogen-sulphur donor sets are described.
Abstract: The preparation, characterisation and biological activities of some oxovanadium(V) and manganese(II) complexes of ligands having nitrogen-sulphur donor sets are described. Reaction of VOCl3 and MnCl2 with HTSCZ (HTSCZ = thiosemicarbazone) resulted in the formation of complexes of the type [VOCl2(TSCZ)], [MnCl(TSCZ)H2O], [VOCl(TSCZ)2] and [Mn(TSCZ)2]. These have been characterized by elemental analyses, molecular weight determinations and conductivity measurements and found to be monomeric and nonelectrolytes. Distorted trigonal bipyramidal (1∶1) and octahedral (1∶2) geometries for the vanadium(V) complexes and a tetrahedral geometry for the manganese(II) complexes are proposed. All the free ligands and their complexes have been tested in vitro against a number of pathogenic fungi and bacteria and were found to possess good fungicidal and bactericidal properties.
Panjab University, Chandigarh1, University of Sydney2, University of Jammu3, Academy of Sciences of Uzbekistan4, University of Rajasthan5, Joint Institute for Nuclear Research6, University of Washington7, Central China Normal University8, University of Marburg9, Lund University10, Shanxi Teachers University11
TL;DR: In this paper, the angular distribution of projectile-associated He fragments from Au induced reactions in nuclear emulsions at 10.7 A GeV have been measured with a precision of ± 0.1 mrad.
TL;DR: In this paper, 3-Alkyl-2-thiazolylidenaminodichlorophosphines were used to give new classes of monothiophosphoric esters.
Abstract: 3-Alkyl-2-thiazolylidenaminodichlorophosphines 1 react with p-cresol and sulfur as well as with diethylamine and sulfur to give new classes of monothiophosphoric esters, namely (3-alkyl-2-thiazolylidenamido)bis(O-4-methylphenyl)thiophosphates 3 and (3-alkyl-2-thiazolylidenamido)bis(diethylamido)thiophosphates 4, respectively. The products exhibit fungicidal activity against the pathogen Macrophomina phaseolina.
TL;DR: In this article, a new series of biologically active oxovanadium(V) complexes of benzothiazolines derived from heterocyclic ketones and 2-mercaptoaniline were synthesized and characterized by elemental analyses, molecular weight determinations and conductance measurements.
Abstract: A new series of biologically active oxovanadium(V) complexes of benzothiazolines derived from heterocyclic ketones and 2-mercaptoaniline were synthesized and characterized by elemental analyses, molecular weight determinations and conductance measurements. Spectroscopic studies indicate coordination of sulphur and the azomethine nitrogen to the metal. All the free ligands and their complexes have been tested in vitro against a variety of pathogenic fungi and bacteria and were found to possess appreciable fungicidal and bactericidal properties.
TL;DR: In this paper, the second-order rate constants were calculated to be 2.04 × 10−2 dm3 mol−1 and 2.72 × 10 −2dm3 ml−1 s−1 for glycine and alanine, respectively, at 35°C and 5.9× 10− 2dm 3 m3 m3 s− 1 s−2 for threonine at 25°C.
Abstract: The kinetics of oxidation of amino acids viz. glycine, alanine, and threonine with bismuth(V) in HClO4–HF medium have been studied. The kinetics of the oxidation of all these amino acids exhibit similar rate laws. The second-order rate constants were calculated to be 2.04 × 10−2 dm3 mol−1 and 2.72 × 10−2 dm3 mol−1 s−1 for glycine and alanine, respectively, at 35°C and 5.9 × 10−2 dm3 mol−1 s−1 for threonine at 25°C. All the possible reactive species of both bismuth(V) and amino acids have been discussed and a most probable kinetic model in each reaction has been envisaged. © 1994 John Wiley & Sons, Inc.
TL;DR: In this paper, template condensation of α-diketones such as 2,3-butanedione or benzil with 1,8-diamino-3,6-diaza octane in the presence of Cr(III), Fe(III) and Co(II) results in the formation of macrocyclic complexes of the type [MLX2]X and [CoLX]X.
Abstract: Template condensation of α-diketones such as 2,3-butanedione or benzil with 1,8-diamino-3,6-diazaoctane in the presence of Cr(III), Fe(III) and Co(II) results in the formation of macrocyclic complexes of the type [MLX2]X and [CoLX]X (where M=Cr(III), Fe(III), L=N4 macrocycle and X=NO3− or Cl−). The complexes have been characterized by elemental analyses, conductance and magnetic measurements, molecular weight determinations, infrared and diffuse reflectance spectral studies.
TL;DR: Azaphospholes with an anellated pyridine ring have become available only recently as discussed by the authors, and only six a-fused azaphospholopyridine are known:
Abstract: Azaphospholes with an anellated pyridine ring have become available only recently1. Representatives of six a-fused azaphospholopyridine are known:
TL;DR: In this paper, the effects of Pb doping on the electronic structure of the Bi-O and Cu-O planes were studied using core-level photoemission, showing that the rare-earth doping at the Ca site causes an increase in the valence state of Bi and a decrease in average Cu valence.
TL;DR: A facile synthesis of spiroindole derivatives, spiro[3H-indole-3,4'-2,3',4,5,6,7'-hexahydro-lH-pyrano[2, 3-b: 6,5-b']dipyrrole]-2(1H)-ones (IV) was achieved by dry heating of substituted indole-2.3-diones with 2.5pyrrolidinone or N-methyl-2pyrrinone as discussed by the authors.
Abstract: A facile synthesis of novel spiroindole derivatives, spiro[3H-indole-3,4'-2',3',4',5',6',7'-hexahydro-lH-pyrano[2,3-b: 6,5-b']dipyrrole]-2(1H)-ones (IV), together with 2,3-dihydro-3-(2,3,4,5-tetrahydro-2-oxo-1H-pyrrole-3-ylidene)-1H-indol-2-ones (II), was achieved by dry heating of substituted indole-2,3-diones with 2-pyrrolidinone or N-methyl-2-pyrrolidinone
TL;DR: In this paper, the Compton profile of polycrystalline yttrium was measured using 59.54 keV gamma-rays and compared with available APW band structure calculations, with and without electron correlation effects.
Abstract: The first measurement of the Compton profile of polycrystalline yttrium is reported. The data, obtained using 59.54 keV gamma-rays are compared with available APW band structure calculations, with and without electron correlation effects. Theoretical computations have also been carried out using the renormalized-free-atom (RFA) model for various 4d-5s configurations. It is found that the present experimental data are in better agreement with the APW band structure calculation without an electron correlation correction. Among the RFA calculations, the best agreement between theory and experiment is found if the outer electron configuration is chosen as 4d1 5s2.
TL;DR: In this paper, a series of novel spiro [3H-indole-3, 2′-(1′H)[1, 2, 4]triazolo[5, 1-d][1, 3, 5]thiadiazepine]-2, 5′-( 1H, 4′H)-diones (II) have been synthesized by the condensation of novel 1, 3-dihydro-3-[(1H]-triazol-3-yl)imino]-2-ones (I) with thio
Abstract: A series of novel spiro [3H-indole-3, 2′-(1′H)[1, 2, 4]triazolo[5, 1-d][1, 3, 5]thiadiazepine]-2, 5′-(1H,4′H)-diones (II) have been synthesized by the condensation of novel 1, 3-dihydro-3-[(1H-[1, 2, 4]-triazol-3-yl)imino]-2H-indol-2-ones (I) with thioacids, viz. mercaptoacetic and 2-mercaptopropionic acid in dry toluene. I were prepared by the reaction of indole-2, 3-diones with 3-amino-1, 2, 4-triazole in absolute ethanol. All the compounds have been characterized on the basis of elemental and spectral studies and have been screened for their antibacterial activity.
TL;DR: Avian species reflect biological magnification of OC residues presumably due to their food habits, and DDT residues generally showed the following order in tissues of birds examined: fantail snipe > red wattled lapwing > blackwinged stilt > flamingo > large pied wagtail.
TL;DR: In this paper, the first rapidity density distributions from relativistic collisions between truly heavy nuclei are presented and compared with expectations from a linear extrapolation of results obtained from collisions with lighter nuclei.
Journal Article•
TL;DR: DMBA (195 nmol/50 microliters of acetone/animal) was applied topically over the dorsal skin of the mice and tumors were promoted by repeated applications of croton oil (1% in acetone, three times per week) after two weeks of DMBA application.
Abstract: SUMMARY DMBA (195 nmol/50µl of acetone/animal) was applied topically over the dorsal skin of the mice and tumors were promoted by repeated applications of croton oil (1% in acetone, three times per week) after two weeks of DMBA application Skin papillomas appeared in 100% animals in control as well as in groups treated orally with Liv52 at post-initiational stages and continuously at periinitiational and post-initiational stages of papillomagenesis When Liv52 was given orally at the peri-initiational stage of papillomagenesis, the percentage of mice bearing tumors was 75% and the tumor mean per mouse was reduced to 40 ± 163 as compared to 75 ± 354 in the control group after 15 weeks of observation The tumor mean per mouse was observed to be 475 ± 055 and 25 ± 057 in the groups treated orally with Liv52 at the post-initiational stages and continuously at periinitiational and post-initiational stages of papillomagenesis respectively Similarly, the cumulative number of papillomas after 15 weeks was 30 in the control group, which was reduced to 10 in the animals treated with Liv52 continuously at peri-initiational and post-initiational stages The cumulative number of papillomas was also reduced to 16 and 19 in animals treated with Liv52 at peri-initiational and post-initiational stages, respectively
TL;DR: In this article, a new class of 16 organotitanium(IV) and organozirconium(IV)-chelates with biologically active monofunctional bidentate semicarbazones having the O⌢N donor system were prepared by reacting 1∶1 and 1∵2 stoichiometric proportions of bis(cyclopentadienyl)titanium dichloride and bis-(cycledienyl)-zirconiam(IV), respectively, with the appropriate ligand, prepared by condensing heterocyclic ket
Abstract: A new class of 16 organotitanium(IV) and organozirconium(IV) chelates with biologically active monofunctional bidentate semicarbazones having the O⌢N donor system were prepared by reacting 1∶1 and 1∶2 stoichiometric proportions of bis(cyclopentadienyl)titanium(IV) dichloride and bis(cyclopentadienyl)zirconium(IV) dichloride with the appropriate ligand, prepared by condensing heterocyclic ketones and semicarbazide hydrochlorides in presence of NaOAc. Trigonal bipyramidal and octahedral structures have been suggested for the 1∶1 and 1∶2 (M∶L) complexes of titanium(IV) and zirconium(IV), respectively, on the basis of spectral analyses.
TL;DR: Some Schiff base derivatives of aluminium having the general formula (OPri)3-nAl[O(NH2)C:NN:C(CH3)R]n (where n=1,2 and 3; R=C4H3O, C4H 3S, C5H4N and C10H7) have been synthesised by the reactions of semicarbazones of the methyl ketones of heterocyclic aromatic compounds with aluminium isopropoxide in stoichiometric ratios in refluxing benzene.
Abstract: Some new Schiff base derivatives of aluminium having the general formula (OPri)3-nAl[O(NH2)C:NN:C(CH3)R]n (where n=1,2 and 3; R=C4H3O, C4H3S, C5H4N and C10H7) have been synthesised by the reactions of semicarbazones of the methyl ketones of heterocyclic aromatic compounds with aluminium isopropoxide in stoichiometric ratios in refluxing benzene. The replacement reactions of isopropoxy aluminium (III) derivatives with tert.butanol have also been studied. All these derivatives have been characterised by conductance measurements, elemental analysis and molecular weight determination. Their probable structures have been proposed on the basis of infrared and 1H NMR spectral studies. Referee I: P. R. Shukla Referee II: M. Athar
TL;DR: In this article, several new complexes of oxovandium(V) and manganese(II) with the monobasic bidentate ligands 2-acetylnaphthalene semicarbazone, 2acetylthiophene semicarbazer, 2-acetylfuran semicarazone and 2-hexacoordinated octahedral geometries for 1:1 and 1:2 (M:L) oxovanadium complexes have been proposed.
Abstract: Several new complexes of oxovandium(V) and manganese(II) with the monobasic bidentate ligands 2-acetylnaphthalene semicarbazone, 2-acetylthiophene semicarbazone, 2-acetylfuran semicarbazone and 2-acetylpyridine semicarbazone have been prepared and characterized by elemental analysis, magnetic moments, IR, 1H NMR and electronic spectral studies. The complexes were monomeric and non-electrolytes. A probable tetracoordinated tetrahedral geometry for manganese complexes and a pentacoordinated distorted trigonal bipyramidal and hexacoordinated octahedral geometries for 1:1 and 1:2 (M:L) oxovanadium complexes, respectively, have been proposed. Some representative complexes of manganese and oxovanadium are found to have remarkable antifungal and antibacterial activities.