Institution
Walter Sisulu University
Education•Mthatha, South Africa•
About: Walter Sisulu University is a education organization based out in Mthatha, South Africa. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 868 authors who have published 1362 publications receiving 15313 citations. The organization is also known as: WSU.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), Medicine, Higher education, Health care
Papers published on a yearly basis
Papers
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University of KwaZulu-Natal1, Universidade Federal de Minas Gerais2, Oswaldo Cruz Foundation3, University of Cape Town4, National Health Laboratory Service5, Centre for the AIDS Programme of Research in South Africa6, University of the Witwatersrand7, Stellenbosch University8, Max Planck Society9, University of the Free State10, Walter Sisulu University11, University of California, Riverside12, University of Oxford13, Temple University14, University of Washington15
TL;DR: A newly arisen lineage of SARS-CoV-2 (designated 501Y.V2) was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province.
Abstract: Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3-5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu-Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data-which show rapid expansion and displacement of other lineages in several regions-suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6-8.
1,171 citations
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University of KwaZulu-Natal1, Universidade Federal de Minas Gerais2, Oswaldo Cruz Foundation3, University of Cape Town4, National Health Laboratory Service5, Centre for the AIDS Programme of Research in South Africa6, University of the Witwatersrand7, Stellenbosch University8, Max Planck Society9, University of the Free State10, Walter Sisulu University11, University of California, Riverside12, University of Oxford13, Temple University14, University of Washington15
TL;DR: In this paper, the authors describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y).
Abstract: Summary Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for significant virus evolution. Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance. This lineage emerged in South Africa after the first epidemic wave in a severely affected metropolitan area, Nelson Mandela Bay, located on the coast of the Eastern Cape Province. This lineage spread rapidly, becoming within weeks the dominant lineage in the Eastern Cape and Western Cape Provinces. Whilst the full significance of the mutations is yet to be determined, the genomic data, showing the rapid displacement of other lineages, suggest that this lineage may be associated with increased transmissibility.
980 citations
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Sadaf G. Sepanlou1, Saeid Safiri2, Catherine Bisignano3, Kevin S Ikuta4 +198 more•Institutions (106)
TL;DR: Mortality, prevalence, and DALY estimates are compared with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries, and a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017.
670 citations
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Charles N. Rotimi1, Akin Abayomi2, Alash'le Abimiku3, Victoria Adabayeri4 +242 more•Institutions (82)
TL;DR: If the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent.
Abstract: H3Africa is developing capacity for health-related genomics research in Africa Our understanding of genome biology, genomics, and disease, and even human history, has advanced tremendously with the completion of the Human Genome Project. Technological advances coupled with significant cost reductions in genomic research have yielded novel insights into disease etiology, diagnosis, and therapy for some of the world's most intractable and devastating diseases—including malaria, HIV/AIDS, tuberculosis, cancer, and diabetes. Yet, despite the burden of infectious diseases and, more recently, noncommunicable diseases (NCDs) in Africa, Africans have only participated minimally in genomics research. Of the thousands of genome-wide association studies (GWASs) that have been conducted globally, only seven (for HIV susceptibility, malaria, tuberculosis, and podoconiosis) have been conducted exclusively on African participants; four others (for prostate cancer, obsessive compulsive disorder, and anthropometry) included some African participants (www.genome.gov/gwastudies/). As discussed in 2011 (www.h3africa.org), if the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent.
344 citations
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George Washington University1, University of Pretoria2, Yale University3, University of al-Jazirah4, World Health Organization5, Catholic University of Mozambique6, Jimma University7, Walter Sisulu University8, University of Cape Town9, University of Malawi10, University of Ibadan11, Hubert Kairuki Memorial University12, Makerere University13, University of Michigan14, New York University15
TL;DR: Findings from the study showed that countries are prioritising medical education scale-up as part of health-system strengthening, and many innovations in premedical preparation, team-based education, and creative use of scarce research support are identified.
293 citations
Authors
Showing all 893 results
Name | H-index | Papers | Citations |
---|---|---|---|
Guillaume Paré | 70 | 332 | 32822 |
G Justus Hofmeyr | 55 | 176 | 10400 |
Matt W. Hayward | 44 | 187 | 7616 |
Michael J. Somers | 44 | 217 | 8083 |
Rajendra Pant | 29 | 246 | 3516 |
Benjamin Longo-Mbenza | 25 | 140 | 1853 |
Oluwatobi S. Oluwafemi | 24 | 175 | 2111 |
Meenakshi Singh | 23 | 56 | 1811 |
Ehimario U. Igumbor | 23 | 60 | 15841 |
Olanrewaju Oladimeji | 23 | 58 | 15497 |
Hemant Kumar Pathak | 21 | 113 | 1528 |
Francis B. Dejene | 21 | 155 | 1582 |
Chikwela Lawrence Obi | 19 | 28 | 1153 |
Monde Makiwane | 18 | 48 | 1200 |
Adebola O. Oyedeji | 17 | 76 | 1109 |