West Virginia University

About: West Virginia University is a education organization based out in Morgantown, West Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 25632 authors who have published 48308 publications receiving 1343934 citations. The organization is also known as: WVU & West Virginia University, WVU.

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways

Abstract: Apigenin is a nontoxic dietary flavonoid that has been shown to possess anti-tumor properties and therefore poses special interest for the development of a novel chemopreventive and/or chemotherapeutic agent for cancer. Ovarian cancer is one of the most common causes of cancer death among women. Here we demonstrate that apigenin inhibits expression of vascular endothelial growth factor (VEGF) in human ovarian cancer cells. VEGF plays an important role in tumor angiogenesis and growth. We found that apigenin inhibited VEGF expression at the transcriptional level through expression of hypoxia-inducible factor 1alpha (HIF-1alpha). Apigenin inhibited expression of HIF-1alpha and VEGF via the PI3K/AKT/p70S6K1 and HDM2/p53 pathways. Apigenin inhibited tube formation in vitro by endothelial cells. These findings reveal a novel role of apigenin in inhibiting HIF-1 and VEGF expression that is important for tumor angiogenesis and growth, identifying new signaling molecules that mediate this regulation.

Foundations of Component-Based Systems

Abstract: Introduction: component software - a snapshot and future directions Clemens Szyperski Part I. Frameworks and Architectures: 1. Key concepts in architecture definition languages David C. Luckham, James Vera and Sigurd Meldal 2. Acme: a basis for architectural integration David Garlan, Robert Monroe and David Wile 3. An extensible language for composition Markus Lumpe, Franz Achermann and Oscar Nierstrasz 4. A framework for a formal and automated approach to component-based reuse Betty H. C. Cheng and Yonghao Chen Part II. Object-Based Specification and Verification: 5. Behavioral subtyping Gary T. Leavens and Krishna Kishore Dhara 6. Modular specification and verification techniques for object-oriented software components Peter Mueller and Arnd Poetzsch-Heffter 7. Respectful type converters for objects Jeannette M. Wing and John Ockerbloom Part III. Formal Models and Semantics: 8. A formal model of componentware Klaus Bergner, Manfred Broy, Andreas Rausch, Marc Sihling and Alexander Vilbig 9. General semantic spaces for specifications and templates David S. Gibson, Bruce W. Weide, Steven H. Edwards and Scott Pike 10. An implementation-oriented semantics for module composition Joseph Goguen and Will Tracz Part IV. Reactive and Distributed Systems: 11. Composition of reactive system components K. Lano, J. Bicarregui, T. Maibaum and J. Fiadeiro 12. The IOA language and toolset: support for mathematics-based distributed programming Stephen J. Garland and Nancy A. Lynch.

Preovulatory, postovulatory, and postmaternal recognition effects of concentrations of progesterone on embryonic survival in the cow

Abstract: Although fertilization rate usually is very high when male fertility is normal, pregnancy rates are below expectations when defined by the birth of live offspring in response to first service. Factors that affect establishment and retention of pregnancy include 1) preovulatory influences on the follicle and oocyte, 2) early postovulatory uterine and luteal function, 3) concentrations of hormones associated with trophoblastic and endometrial function during maternal recognition of pregnancy, and 4) less-well understood factors during the peri-attachment period. For example, decreased progesterone during preovulatory follicular development leads to a persistent follicle, premature resumption of meiosis, and a high incidence of embryonic death between the 2- and 16-cell stages. Elevated PGF(2alpha) during d 4 to 9 of the estrous cycle not only caused luteolysis but also had a direct embryotoxic effect during the morula-to-blastocyst transition. Ideal conditions during placentation and attachment are not clearly defined. Late embryonic mortality might be increased after ovulation of persistent or immature follicles. Nominal increases in secretion of PGF(2alpha) between d 30 and 35 might be important for attachment and placentation. Lower survival of embryos from wk 5 to wk 7 to 9 of gestation in the cow was associated with lower circulating concentrations of progesterone on wk 5. To maximize embryonic survival in the cow, management must provide high progesterone before estrus, quality detection of estrus, and timely insemination. Luteolytic influences of estradiol-17beta or PGF(2alpha) must be minimized early after mating and during maternal recognition of pregnancy, and high progesterone is needed during the late embryonic/early fetal period.