Showing papers in "American Journal of Hypertension in 1988"

TL;DR: It is postulate that a renal abnormality that contributes to essential hypertension in the general population is a reduced number of nephrons, and congenital variability in filtration surface area may explain why only some, but not all, patients exposed to potentially injurious renal stimuli eventually manifest chronic nephropathy.

TL;DR: The purpose of this study was to examine the variability of 24-hour urinary and serum creatinine levels and Creatinine clearance in normal subjects and to develop nomograms for assessing the adequacy of24-hour urine collections and the data were from a longitudinal research program examining biochemical, hormonal, and hemodynamic parameters innormal subjects.

TL;DR: The hypothesis presented here emphasizes the important role of diet in the treatment of obese hypertensive subjects and the efficacy of caloric restriction, weight loss, and exercise in reducing blood pressure in the obese is linked to diminished insulin and SNS activity and may be viewed as evidence in favor of this hypothesis.

TL;DR: It is concluded that pill count variability is large, even among highly selected subjects, traditional reports of overall pill counts are suboptimal, and pill counts may unreliably measure medication-taking behavior because "supranormal" compliance by this method is improbable but common.

TL;DR: Urinary albumin and NAG excretions are positively correlated with blood pressure and may be useful markers of renal involvement in patients with essential hypertension.

TL;DR: It is concluded that blood pressure reactivity measured in the laboratory may not be readily generalized to changes of pressure in everyday life, as measured by noninvasive ambulatory recorders.

TL;DR: Minimizing cardiac sympathetic drive by strict bedrest and studying beta-blockers with different degrees of ISA in 50 hypertensive patients showed that initially the effect of the drugs is offset by a rise in vascular resistance proportional to the fall in cardiac output, but in the long run blood pressure and vascular resistance were always positively correlated.

TL;DR: H hypertensive diabetic rats (SHR-STZ) had an earlier and more rapid rise in urinary albumin excretion and Angiotensin-converting enzyme inhibition is associated with a reduction in albuminuria in both hypertensive and normotensive models of diabetic nephropathy.

TL;DR: Neuropeptide Y (NPY) is present in the brain, the adrenal medulla, and peripheral sympathetic nerves and potentiates the vascular effect of several stimulatory substances and may contribute to the modulation of blood pressure responsiveness under a number of circumstances.

TL;DR: The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whether there exists an anatomical base for such interrelation with the afferent arteriole of the juxtaglomerular apparatus.

TL;DR: The negative correlation between serum calcium and blood pressure is similar to that obtained in normocalcemic individuals and suggests that raised blood pressure, at least in the milder forms of primary HPT, is only independently associated with the disease.

TL;DR: It is indicated that dietary salt causes increases in intracellular sodium and calcium and that the antihypertensive effect of dietary calcium in salt-sensitive individuals may be attributable in part to preventing this salt-induced elevation in intrACEllular calcium.

TL;DR: Medical therapy with a converting-enzyme inhibitor represents a viable alternative in selected patients with renovascular hypertension, especially those in whom there is a contraindication to surgery or angioplasty.

TL;DR: A compensatory role of ANF in the prevention of blood pressure increase is suggested, which may explain this inappropriate hypostimulation of renin secretion by hypovolemia in these hypertensive states.

TL;DR: Four compliance strategies were compared with education alone to investigate their impact on the control of high blood pressure, finding that education alone does not influence compliance while the specific techniques studied did improve compliance.

TL;DR: The hypothesis that local angiotensin concentrations may exceed those of plasma levels and may play an important role in the tonic control of vascular resistance, cardiac and adrenal functions, and intrarenal events could explain the broad spectrum of activity of angiotENSin-converting enzyme (ACE) inhibitors in hypertensives as well as their continuing antihypertensive activity after plasma ACE levels have been restored.

TL;DR: The patient underwent percutaneous transluminal angioplasty of the right renal artery with subsequent improvement in blood pressure control on reduced, and later, no antihypertensive therapy, illustrating that moyamoya syndrome may be an intracranial manifestation of a systemic arterial disorder.

TL;DR: Dietary Ca2+ and Na+ induced favorable changes in total bodyfat content in both the SHR and WKY, and significant differences in body weight, blood pressure, and total body fat were observed between diet groups in both strains.

TL;DR: It is concluded that sensory stimuli have an important effect on HR and on the variability of MAP and HR, but not on MAP itself, indicating that to some extent blood pressure and its variability are regulated independently.

TL;DR: One hundred and six patients were determined to have renovascular hypertension (RVH) out of 3520 patients with hypertension referred by their physicians for a 1-day blood pressure study (1-day BP study) to evaluate the presence of secondary forms of hypertension.

TL;DR: It is suggested that abnormalities of taste are commonly associated with captopril therapy and may be related to changes in zinc metabolism and this is especially true in patients on long-term, high-dose captoprill therapy.

TL;DR: Dietary calcium supplementation may prove beneficial in lowering systolic blood pressure in the long term and respond dramatically initially to calcium supplementation.

TL;DR: Role of the hypothalamic digitalis-like substance (EDLS) on the hypertension associated with an excess intake of sodium and the releasing mechanism were investigated, and the plasma content of the EDLS was significantly greater in the hypertonic NaCl group than the control group treated with either the artificial CSF or urea solution.

TL;DR: It is proposed that in essential hypertension higher cytosolic free Ca2+ ([Ca2+]i) is associated with hyperactivity of the Na+/H+ antiport and that augmented activity of this transport system explains at least some abnormalities in Na+ metabolism associated with this disease.

TL;DR: In obese rats undergoing a supplemented fast, blood pressure fell almost immediately but then stabilized despite continuing weight loss, and the depressor effect of fasting was reversed within 2 days of refeeding.

TL;DR: The results suggest that vinpocetine may effect vasodilatation through blockade of the slow channel and selective inhibition of CaM-PDE in the vascular smooth muscle.

TL;DR: The data indicate that the antihypertensive effect of calcium in salt-sensitive blacks may be attributable, in part, to Ca-induced natriuresis and an associated volume contraction.

TL;DR: A II can centrally attenuate baroreflex, which might be independent from vasopressin, and in the brain A II can contribute to the central resetting of barore Flex in SHRs.

TL;DR: It is concluded that the computer-assisted diary is an effective way to monitor behavioral states during ambulatory blood pressure monitoring which merits further trial applications.

TL;DR: The results indicate that long-term diuretic treatment may give rise to an intracellular magnesium deficiency and a suppression in cell membrane active transport for sodium, with a resultant increase in intrACEllular sodium content.