Showing papers in "Arthritis & Rheumatism in 1964"

Hemochromatosis and arthritis.

Abstract: Two patients with hemochromatosis and what appears to be a distinctive arthritis are presented. Both showed prominent involvement of the hands, minimal evidence of inflammation, significant x-ray changes and synovial hemosiderin deposition. Five other cases of a similar arthritis were found in a review of 23 cases of idiopathic hemochromatosis. The arthritis is postulated to be the result of iron excess damaging articular tissue in a yet undefined manner.

Inflammatory reaction after intrasynovial injection of microcrystalline adrenocorticosteroid esters.

Abstract: Injection of commercially available microcrystalline adrenocorticosteroid esters into normal canine joints was ac-companied by a leukocyte-rich exudative response, roughly proportional to the dose injected. No tenderness or evidence of pain was noted. Injection of these preparations into normal human joints often induced similar reactions which were sometimes painful. The response varied with the preparation employed and in the case of hydrocortisone acetate, with the manufacturer of the drug. The possible injurious effects of this relatively painless inflammatory response are discussed.

Significance of antibody to dna in systemic lupus erythematosus.

Abstract: A study was made of serum antibody to DNA and nucleoprotein in 35 patients with SLE, using immunofluorescent spot techniques. Anti DNA was confirmed by complement fixation and observation of the “shaggy” nuclear fluorescent pattern. A striking correlation was observed between presence of anti DNA and the acute phase of SLE. Anti-nucleoprotein, the most constant finding, showed only a general correlation of titer with phase of disease. Diagnostic and pathogenetic implications are discussed. Esseva studiate le anticorpore del sero anti acido deoxyribonucleic e nucleo-proteina in 35 patientes con generalisate lupus erythematose. Le studio esseva effectuate con le uso de technicas a spot immunofluorescente. Anticorpore anti acido deoxyribonucleic esseva confirmate per fixation de complemento e le observation del characteristic configuration de fluorescentia in le nucleos. Esseva constatate un frappante correlation inter le presentia de anticorpore anti acido deoxyribonucleic e le phase acute de generalisate lupus erythematose. Anticorpore anti nucleoproteina, le constatation le plus constante, monstrava solmente un correlation general de titro con le phase del morbo. Le signification diagnostice pathogenetic del resultatos del studio es discutite.

The clinical course of kashin-beck disease.

Abstract: Kashin-Beck or Urov disease is described with authority by an astute scholar and clinician, Prof. Nesterov, Director of the Institute for Rheumatism and member of the Academy of Medical Sciences of the USSR in Moscow. The disease is a chronic, disabling, degenerative, generalized osteoarthrosis involving peripheral (symmetrical) joints and spine un-associated with systemic or visceral manifestations. It occurs principally in childhood and results in growth disturbances. It is endemic in Eastern Siberia, Northern China and Northern Korea and is believed to be due to ingestion of cereal grain grown in these areas and infected with the fungus, Fusaria sporotrichiella. The incidence has been considerably reduced and hopefully will soon be eradicated by importing cereals from unaffected areas. This is a classic example of a generalized degenerative joint disease due to environmental causes, unrelated to genetic factors or inborn errors of metabolism.

Role of the finger flexors in rheumatoid deformities of the metacarpophalangeal joints

Abstract: HEN LOOKING for the major cause of deformity in the rheumatoid W metacarpophalangeal joint, several clinical observations offer clues. The characteristics of the early deformity recur with remarkable consistency, being comprised of varying degrees of luxation of the proximal phalanx in a volar and an ulnar direction, and deviation in an ulnar dir~ti0n.l.~ Secondly, the deformity has both passive and dynamic aspects. Passively, the finger can be luxated and deviated more than normal, even though it may be readily returned to a normal position in many patient^.^^^ Dynamically, the finger tracks along a more luxated and ulnarly deviated path during voluntary active flexion.? The passive deformity implies a loss of integrity of the specific structures normally preventing deviation and luxation. This damage in turn is indicative of forces acting consistently in the direction of the passive deformity. The dynamic deformity implies a new balance of forces during MCP flexion, which are in dynamic equilibrium only when the finger is tracking along a more ulnar and luxated path. In fact, some patients are totally unhble to

Rheumatoid arthritis, baker's cyst, and "thrombophlebitis".

Abstract: From a small series of patients hospitalized with rheumatoid arthritis, six cases are presented in which Baker's cysts were associated with pain and swelling of the calf, initially erroneously diagnosed as thrombophlebitis. The pathogenesis of these calf symptoms is reviewed.

Study of rheumatoid factor in a normal population.

Abstract: Five thousand four hundred and sixty-one normal individuals were tested for rheumatoid factor. The latex slide test was positive in 4.1 per cent SHC in 2.4 per cent and SSC in 0.18 per cent. There was no positive correlation of presence of rheumatoid factor and race or sex, but all tests increased in positivity with age. Physical examinations of individuals with at least one test positive for rheumatoid factor showed 5.4 percent had possible or definite rheumatoid arthritis.

Experimentally induced arthritis using intra-articular papain.

Abstract: Daily injection of a crude papain solution into the knee joint of young rabbits continued over a six day period resulted in a degeneration of the articular cartilage within two weeks. The initial findings were elevation and loosening of the cartilage in the weight bearing area followed by thinning and fibrillation of the remaining surface. Microscopic changes consisted of disruption of the cartilage adjacent to the subchondral bone and loss of the superficial layers. Changes in the articular cartilage were similar to changes seen in clinical forms of degenerative arthritis. Le injection diurne de un solution de papaina crude ad in le articulation genicular de juvene conilios, quando continuate durante sex dies, resultava intra duo septimanas in un degeneration del cartilagine articular. Le constatationes initial esseva elevation e distachamento del cartilagine in le in areas sub pression de peso, sequite de tenuifi cation e fibrillation del remanente superficie. Le alterations microscopic que esseva notate consisteva de disruption del cartilagine adjacente al osso subchondral con perdita del stratos superficial. Alterationes in le cartilagine articular esseva simile a alterationes vidite in formas clinic de arthritis degenerative.

Studies on adjuvant-induced polyarthritis in rats. III. The effect of “immunosuppressive agents” on arthritis and tuberculin hypersensitivity

Abstract: Methotrexate, 6-mercaptopurine and total body x-irradiation, given to rats injected with mycobacterial adjuvant, suppressed the development of polyarthritis without altering hypersensitivity to old tuberculin. Mechlorethamine hydrochloride was without effect. This dissociation of arthritis and tuberculin hypersensitivity suggests that sensitization to tuberculoprotein plays no direct role in producing the arthritis. Methotrexate and 6-mercaptopurine also suppressed the early inflammation at the site of adjuvant injection indicating an antiinflammatory action which is independent of their effects on immunologic mechanisms. Methotrexato, 6-mercaptopurina, e roentgeno-irradiation del corpore total, quando administrate a rattos que habeva recipite injectiones de adjuvante mycobacterial, supprimeva le disveloppamento de polyarthritis sin alterar le hypersensibilitate pro tuberculina ancian. Hydrochloruro de mechlorethamina remaneva sin ille effecto. Iste dissociation de arthritis e hypersensibilitate pro tuberculina suggere que le sensibilisation pro tuberculoproteina ha nulle directe rolo in le production de arthritis. Methotrexato e 6-mercaptopurina etiam supprimeva le precoce inflammation al sito del injection del adjuvante, lo que reflecte un effecto anti-inflammatori del duo agentes le qual es independente de lor rolo in le mechanismo immunologic.

Enzymatic degradation of chondromucoprotein by cell-free extracts of human cartilage.

Abstract: Normal and fibrillated human articular cartilage contains significant levels of an agent which reduces the viscosity of cartilage protein-polysaccharides. This agent is cyanide and heat sensitive and has typical enzyme behavior. It splits the mucoprotein at or near the P-P bond. This enzyme may initiate the degradation of ground substance seen in early osteoarthritis. Normal e fibrillate cartilagine articular de humanos contine nivellos significative de un agente que reduce le viscositate de proteino-polysaccharidos de cartilagine. Iste agente es sensibile pro calor e cyanido e manifesta un comportamento typicamente enzymatic. Illo finde le mucoproteina in o proxime ad le ligamine P-P. II es possible que iste enzyme initia le degradation de substantia de base que es a observar in osteoarthritis precoce.

Antinuclear factor in systemic lupus erythematosus. a consideration of the immunofluorescent method of detecting antinuclear antibodies, with results obtained in a family study.

Abstract: An immunofluorescent technique used for demonstrating antinuclear factor is discussed and the possible influence of differences in method on A.N.F. findings in family studies already reported is considered. The incidence of serum antinuclear factor in first degree relatives of patients suffering from systemic lupus erythematosus was higher than in matched population controls; the difference was a small but a significant one. Es discutite un technica immunofluorescente utilisate pro le demonstration del factor antinuclear. Le possible influential de differentias in methodo super constatationes de factor antinuclear in previemente reportate studios familial es considerate. In consanguineos del prime grado de patientes suffrente de systemic lupus erythematose le incidentia del factor antinuclear in Ie sero esseva plus grande que in le appariate population de controlo. Iste differentia esseva micre sed significative.

Lactic dehydrogenase (ldh) and transaminase (got) activity of synovial fluid and serum in rheumatic disease states, with a note on synovial fluid ldh isozymes.

Abstract: Lactic acid dehydrogenase (LDH) and glutamic-oxalacetic transaminase determinations were carried out on the serums and synovial fluids of patients with a variety of rheumatic diseases. The LDH activity of the synovial fluid was elevated in patients with rheumatoid degenerative joint disease. Transaminase activity was normal in both serum and synovial fluid in all cases. Starch gel zymograms of LDH showed qualitatively increased amounts of the isozyme LDH 5 in the pathological synovial fluids.

Simultaneous salicylate concentrations in synovial fluid and plasma in rheumatoid arthritis.

Abstract: Total, free (diffusible) and proteinbound salicylate concentrations were determined in synovial fluid samples obtained from 12 patients with rheumatoid arthritis, and compared with simultaneously obtained plasma concentrations. Free salicylate concentrations were essentially identical in the two fluids, implying complete equilibrium. Both the total and protein-bound salicylate concentrations were consistently lower in the synovial fluids than in the corresponding plasmas; this difference may be explained by the lower albumin concentration in the joint fluid. Le concentrationes de salicylato total, libere (diffusibile), e ligate a proteina esseva determinate in specimens de fluido synovial obtenite ab 12 patientes con arthritis rheumatoide, e esseva comparate con ie concentrationes in simultaneemente obtenite specimens de plasma. Le concentrationes de libere salicylato esseva essentialmente identic in le duo fluidos, lo que implica complete equilibrio. Le concentrationes de salicylato total e de salicylato ligate a proteina esseva uniformemente plus basse in le fluidos synovial que in le correspondente plasmas; iste differentia pote esser explicabile per le plus basse concentration de albumina in le fluido del articulationes.

Aseptic necrosis in systemic lupus erythematosus. Report of a case involving six joints

Abstract: Aseptic necrosis involving 6 joints (shoulders, hips, one knee and one ankle) is described in a young woman with systemic lupus erythematosus (SLE) treated with systemic corticosteroids. This is the largest number of joints involved by this process in a single case yet reported. Vasculitis, with ischemia of bone, is thought to be the pathogenesis of the necrotic changes observed. Es describite necrosis aseptic afficiente sex articulationes (spald coxas, un genu, un cavilia) in un juvene femina con disseminate lupus erythematose sub therapia a corticosteroides in administration constitutional. Isto es le plus grande numero de articulationes unquam reportate como afficite per iste processo in un caso particular. Vasculitis, con ischemia del ossos, es reguardate como como le mechanismo del pathogenese del alterationes necrotic observate.

The costovertebral joints, anatomical-clinical observations in arthritis.

Abstract: Costovertebral arthritis was found to be a frequent condition in a study of 346 skeletons and 100 roentgenograms. It followed a definite pattern of distribution, which seems to be related to the anatomical characteristics of the joints and the ribs involved at the different thoracic levels. No differences were found between the races and sexes. In a few patients in which the diagnosis of costovertebral arthritis was established, local treatment was tried with good results.

Excretion of tryptophan metabolites by patients with rheumatoid arthritis

Abstract: The urinary excretion of tryptophan metabolites was measured in control subjects, in patients with active rheumatoid arthritis, and in patients with related disorders. After tryptophan loading, 12/15 female patients and 4/5 male patients with active rheumatoid arthritis and a positive latex test had significantly elevated levels of one or more of the tryptophan metabolites measured. Hydroxykynurenine and kynurenine were the metabolites most frequently elevated. Although excretion of 4-pyridoxic acid was in the normal range in these subjects, administration of supplements of pyridoxine restored tryptophan metabolism toward normal in a group of 11 female patients in which this was studied. The data suggests that a high percentage of these patients have a functional pyridoxine deficiency demonstrable in tryptophan metabolism only by means of a tryptophan loading test. Le excretion urinari de metabolitos de tryptophano esseva mesurate in sub-jectos de controlo, in patientes con active arthritis rheumatoidee, e in patientes con relationate disordines. Post cargation con tryptophano, 12 inter 15 patientes feminin e 4 inter 5 patientes mascule con active arthritis rheumatoidee e posi-tivitate del test a latex monstrava significative elevationes de un o plures del metabolitos de tryptophano mesurate. Hydroxycynurenina e cynurenina esseva le metabolitos elevate le plus frequente-mente. Ben que le excretion de acido 4-pyridoxic esseva in iste subjectos intra le limites del norma, le administration de supplementos de pyridoxina restaurava le metabolismo de tryptophano in le direction de valores normal in un gruppo de 11 patientes feminin in qui iste aspecto del question esseva studiate. Le datos suggere que un alte procentage de iste patientes ha un carentia functional de pyridoxina que es demonstrabile in le metabolismo de tryptophano solmente per medio de un test a cargation de tryptophano.

Effect of chloroquine on the sulfhydryl group and the denaturation of bovine serum albumin

Abstract: Chloroquine diphosphate was demonstrated to be capable of blocking the sulfhydryl disulfide interchange reaction that ordinarily occurs during the denaturation of bovine serum albumin by either heat or urea. Chloroquine was also shown to inhibit the reduction of ferricyanide by cysteine, and to bind to certain sulfhydryl groups of human serum protein when present in concentrations found in patients taking the compound for rheumatoid arthritis. Esseva demonstrate que diphosphato de chloroquina es capace de blocar le reaction de intercambio de sulfhydrylo e disulfide que ordinarimente occurre durante le disnaturation de albumina in sero bovin per medio de calor o de urea. Esseva demonstrate etiarn que chloroquina inhibi le reduction de ferricyanido per systeina e que illo se liga a certe gruppos sulfhydrylic in le proteina de sero human quando illo es presente in concentrationes que es trovate in patients qui recipe le composito pro le tractamento de arthritis rheumatoide.

Tryptophan metabolism in rheumatic disease.

Abstract: Five tryptophan metabolites were measured in the urine after an oral tryptophan load in patients with rheumatoid arthritis, scleroderma, systemic lupus and a variety of other diseases. An excessive excretion of kynurenine and 3-hydroxykynurenine was a common but nonspecific occurrence in rheumatic disease. The excretion did not correlate well with various clinical parameters. Inhibition of pyridoxal-dependent hepatic enzymes may be the cause of the abnormality but the mechanism is unknown. Cinque metabolitos de tryptophano esseva mesurate in le urina post cargas oral de tryptophano administrate a patientes con arthritis rheumatoidee, scleroderma, lupus generalisate, e un varietate de altere morbos. Un excretion excessive de kynurenina e 3-hydroxykynurenina esseva un occurrentia commun sed non specific in casos de morbo rheumatic. Le excretion revelava nulle nette correlation con ulle del parametros clinic studiate. Inhibition de enzymas hepatic que depende de pyridoxal es possibilemente le causa del anormalitate mentionate, sed le mechanismo non es clar.

Personality patterns of rheumatoid arthritic patients.

Abstract: Thirty-five female and ten male rheumatoid arthritic outpatients were administered the Minnesota Multiphasic Personality Inventory (MMPI). Their MMPI group profile was found to resemble a classical neurotic pattern with elevations of the MMPI scales could be accounted for by the presence of rheumatoid arthritis-associated somatic complaints contained within the items of the scales. Further analyses with regard to hostility were also undertaken. Le Inventario Minnesota Multiphasic de Personalitate (IMMP) esseva administrate a 35 feminin e 10 mascule patientes non-hospitalisate de arthritis rheumatoide. Le profilo del gruppo se monstrava como simile a un classic configuration neurotic con elevationes del scalas de hypochondriasis, depression, e hysteria. Un certe grado de elevation de iste scalas del IMMP es explicabile per le inclusion intra le scalas de Crete gravamines somatic que es associate con le presentia de arthritis rheumatoide. Analyses addition-al con respecto a hostilitate esseva etiam interprendite.

Calcinosis universalis complicating dermatomyositis-its treatment with Na2EDTA. Report of two cases in children

Abstract: The treatment of calcinosis by chelation in two children with dermatomyositis is described. The amount of calcium in skin, muscle and fascia was chemically determined before and after chelation in one child. The amount in fascia was strikingly less after chelation than before chelation, though still elevated. Neither child showed clinical improvement. Treatment of calcinosis with chelating agents might be more effective if the drug were given over more prolonged periods. Es describite le tractamento de calcinosis per chelation in duo casos de dermatomyositis in juveniles. In un del patientes, le quantitate de calcium in pelle, musculo, e fascia esseva determinate chimicamente ante e post le chelation. Le quantitate de fascia post le chelation esseva frappantemente minus que ante le chelation, sed illo esseva ancora elevate in supra del norma. Nulle del duo juveniles monstrava melioration clinic. Il es possible que le tractamento de calcinosis con agentes de chelation esserea plus effi cace si le pharmaco esseva administrate plus perdurativemente.

A clinical-pathological study of aleutian mink disease; an experimental model for study of the connective-tissue diseases.

Abstract: A chronic disease spontaneously occurring in mink is described. This disease is characterized by a genetic predisposition for mink carrying the Aleutian gene. It is manifested by renal, hepatic, and possibly arterial changes. There is marked hyperglobulinemia. The pathologic features of the disease are reviewed. Current studies have extended the knowledge regarding the hematologic and biochemical abnormalities. Comparison of the abnormalities of this disease to human connective-tissue diseases is made. Es describite un morbo chronic que occurre spontaneemente in visones. Iste morbo es characterisate per su predilection a base genetic pro visones portator del gen aleutian. Illo se manifesta in alterationes renal, hepatic, e possibilemente arterial. Marcate grados de hyperglobulinemia es presente. Le characteristicas pathologic del morbo es revistate. Studios currentemente in progresso ha servite a extender nostre cognoscentias relative al anormalitates hematologic e biochimic. Es interprendite un comparation de iste morbo con le morbos de tissu conjunctive in humanos.

Relationships between genitourinary infection and complicating arthritis.

Abstract: Sixty-nine episodes of arthritis associated with urethritis or cystitis were studied in 58 heterosexual Caucasian males and 7 episodes in 2 North American Indians, the observations being made in Vancouver, British Columbia. The arthritis following gonorrhea was similar to that following non-gonococcal urethritis and in both groups extramarital venereal exposure was the usual initiating event. No evidence could be found that mycoplasmal or viral agents were responsible for the arthritis. Esseva studiate 69 episodios de arthritis in association con urethritis o cystitis in 58 masculos heterosexual Caucasian e 7 episodios in 2 indios nord-american. Iste observationes esseva facite in Vancouver in Columbia Britannic. Le arthritis que sequeva gonorrhea esseva simile a illo que sequeva urethritis nongonococcal, e in ambe gruppos exposition veneree extramarital esseva le usual evento initiante. Nulle evidentia esseva trovate que agentes mycoplasmal o viral esseva responsabile pro Ie arthritis.

Erythrocyte survival in rheumatoid arthritis.

Abstract: Thirty patients with active rheumatoid arthritis were transfused with chromium-51 labeled erythrocytes from either normal or rheumatoid donors. Three sets of identical twins discordant for rheumatoid arthritis had a cross transfusion from a healthy donor to the affected recipient. In no instance was there any significant shortening of erythrocyte survival which could not be attributed to minor blood group incompatibility. The presence of rheumatoid factor in either the donor, the recipient, or both did not effect erythrocyte survival. Trenta patientes con active arthritis rheumatoidee recipeva transfusiones de erythrocytos a marcage con chromo-51 ab donatores normal o rheumatoidee. In tres pares de geminos identic con discordantia pro arthritis rheumatoidee esseva le subjectos de un experimento de transfusion cruciate ab un donator normal a un recipiente afficite. Esseva notate nulle caso de un reduction significative del durata vital del erythrocytos gue non poteva esser attribuite a minor incompatibilitates de gruppo de sanguine. Le presentia de factor rheumatoidee in le donator, in le recipiente, o in ambes non afficeva le durata vital del erythrocytos.