Showing papers in "Bone in 2022"

TL;DR: In this paper , the authors investigated the function and mechanism of methyltransferase-like 3 (Mettl3) in chondrocytes in inflammation and found that the expression of Mettl-3 decreased both in vivo TMJ OA mice and in vitro inflammatory stimulation.

TL;DR: In this paper, the authors investigated the function and mechanism of methyltransferase-like 3 (Mettl3) in chondrocytes in inflammation and found that the expression of Mettl-3 decreased both in vivo TMJ OA mice and in vitro inflammatory stimulation.

TL;DR: In this article , the authors evaluated the incidence of de novo bone metastasis across all primary cancer sites and their impact on survival by primary cancer site, age, race, and sex.

TL;DR: In this paper , the authors investigated the potential benefit of calcitriol therapy given to patients hospitalized with COVID-19 infection and found an improvement in oxygenation among subjects who received calcitriols.

TL;DR: In this article, the authors investigated the potential benefit of calcitriol therapy given to patients hospitalized with COVID-19 infection and found an improvement in oxygenation among subjects who received calcitriols.

TL;DR: The recent biomimetic scaffoldbased and scaffold-free approaches in bone tissue engineering, focusing on materials and fabrication methods used, are overviewed in this paper , where the biomimic vascularized approaches are also discussed, namely the development of pre-vascularized scaffolds and prevascularised cellular aggregates.

TL;DR: The recent biomimetic scaffoldbased and scaffold-free approaches in bone tissue engineering, focusing on materials and fabrication methods used, are overviewed in this article, where the biomimic vascularized approaches are also discussed, namely the development of prevascularized scaffolds and pre-vascularised cellular aggregates.

TL;DR: In this article , the authors summarized the current understanding of the RANKL-RANK-OPG system in the context of the bone and the immune system as well as the impact of this pathway in disease conditions, including cancer development and metastasis.

TL;DR: In this article , the authors summarize the data currently available on the role of HtrA1 in skeletal diseases such as Osteoporosis, Rheumatoid Arthritis, Osteoarthritis and Intervertebral Disc Degeneration (IDD).

TL;DR: The bisphosphonates ((HO) 2 P( O )CR 1 R 2 P (O)(OH) 2 , BPs) were first shown to inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed molecular understanding of the relationship between their varied chemical structures and biological activity was elucidated as mentioned in this paper .

TL;DR: A review of the current understanding of the iron-phosphate axis as well as complications of intravenous iron-induced hypophosphatemia is presented in this paper , where the authors identify the typical clinical manifestations of IV-IR-induced HPs and identify a specific pattern of biochemical changes (hyperphosphaturic HPs triggered by high FGF23 that causes low 1,25 (OH)2 vitamin D, hypocalcemia and secondary hyperparathyroidism).

TL;DR: A review of the current understanding of the iron-phosphate axis as well as complications of intravenous iron-induced hypophosphatemia is presented in this paper, where the authors identify the typical clinical manifestations of IV-IR-induced HPs and identify a specific pattern of biochemical changes (hyperphosphaturic HPs triggered by high FGF23 that causes low 1,25 (OH)2 vitamin D, hypocalcemia and secondary hyperparathyroidism).

TL;DR: In this article, the authors examined fundamental bone parameters among mice treated with escalating viral loads and found a significant reduction in several bone parameters and corresponding robust increases in osteoclast number observed within 2 weeks post-infection in surviving asymptomatic and moderately affected mice.

TL;DR: In this paper , the effects of SARS-CoV-2 infection on the musculoskeletal system were examined among mice treated with escalating viral loads, showing a significant reduction in several bone parameters and corresponding robust increases in osteoclast number observed within 2 weeks post-infection in surviving asymptomatic and moderately affected mice.

TL;DR: In this paper, a review of existing literature on changes of bone turnover markers (BTMs), bone mineral density (BMD), and fracture risk following bariatric surgery and provided advice on management based on expert opinion.

TL;DR: In this article , a nanocomposite biomaterial ink (Mg-PCL) comprising of magnesium hydroxide nanoparticles and polycaprolactone thermoplastic was developed for 3D printing of strong and bioactive bone regenerative scaffolds.

TL;DR: In this paper, a nanocomposite biomaterial ink (Mg-PCL) comprising of magnesium hydroxide nanoparticles and polycaprolactone thermoplastic was developed for 3D printing of strong and bioactive bone regenerative scaffolds.

TL;DR: Tetracyclines are a broad-spectrum class of antibiotics that have unclear actions with potentially lasting effects on bone metabolism as discussed by the authors , and they are commonly prescribed as long-term systemic therapy for the treatment of acne in healthy adolescents and young adults.

TL;DR: In this paper , a working group of the European Calcified Tissue Society performed an updated review of existing literature on changes of bone turnover markers (BTMs), bone mineral density (BMD), and fracture risk following bariatric surgery and provided advice on management based on expert opinion.

TL;DR: In this article , the association of circulating microRNpAs with incident fragility fracture in T2D patients was examined and three miRNAs were found to be significantly associated with incident diabetic fragility fractures.

TL;DR: In this article , the association of Type 2 Diabetes mellitus (T2DM) with prevalent and incident vertebral fractures was found to be as strong as they are for hip and other non-vertebral fractures.

TL;DR: A systematic review and meta-analysis was conducted to investigate the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults as mentioned in this paper .

TL;DR: In this paper, the authors found that T2DM is a stronger risk factor for hip and proximal humerus fractures than for vertebral and wrist fractures, but only weakly with incident clinical vertebral fracture.

TL;DR: In this paper, the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults was investigated.

TL;DR: In this paper , a loading-driven mechanism of angiogenesis and the formation of type H vessels in bone was found to influence osteogenesis and haematopoiesis in the bone microenviroment.

TL;DR: In this article , the authors performed in vitro LGR6 knockdown and overexpression experiments in murine osteoblastic cells and found decreased Lgr6 levels results in reduced osteoblast proliferation, differentiation, and mineralization.

TL;DR: A review of the role of the macrophage in bone regeneration and repair is surveyed before discussing recent biomaterial and drug-delivery based approaches that target macocyte modulation with the goal of accelerating and enhancing bone tissue regeneration as discussed by the authors .

TL;DR: In this article , SM04690, a small-molecule inhibitor of the Wnt signaling pathway, is able to promote cartilage regeneration in a rat model of knee joint osteoarthritis.

TL;DR: A comprehensive overview of the skeletal effects of exposure to hypobaric hypoxia and high altitude can be found in this article, with a focus on the bone mineral density (BMD) and cortical morphology.

TL;DR: A comprehensive overview of the skeletal effects of exposure to hypobaric hypoxia and high altitude can be found in this paper , with a focus on the bone mineral density (BMD) and cortical morphology.