Showing papers in "Brain, Behavior, & Immunity - Health in 2022"

TL;DR: In this article , the authors provide summarized information about the neurological symptomatology and the brain pathogenic mechanisms involved and reported in COVID-19, which is a major novel challenge for neuroscience.

TL;DR: In this paper , the safety of low-dose Naltrexone (LDN) was explored in patients with Post COVID-19 Syndrome (PCS), defined by NICE as patients with ongoing symptoms 12 or more weeks after initial infections with SARS-CoV-2 where alternative explanation for symptoms cannot be found.

TL;DR: In this article , the authors focus on transforming growth factor beta (TGFB), a cytokine that has been previously associated with ME/CFS and has an important role in circadian rhythms, especially in peripheral cells.

TL;DR: Yoga is an ancient system for integrating the mind, body, and spirit, and the benefits of yoga for mental and physical health are rooted in the practice's origins: in yoga, stress is said to be the root of all diseases as discussed by the authors .

TL;DR: In this article , a systematic review and meta-analysis is proposed to estimate the prevalence of depression and anxiety in MS patients and to perform subgroup analyses (study type, Extended Disability Status Scale/EDSS, duration of MS, region, type of MS) on observational studies.

TL;DR: This article reported a case series of two patients who developed aseptic meningitis after vaccination after COVID-19 pandemic and reported that the BNT-162b2 (Pfizer-BioNTech) vaccine is one of the most widely used vaccines.

TL;DR: In this paper , the authors investigated the effect of circadian disruption on cancer-induced inflammation in an orthotopic breast cancer model, using a validated chronic jetlag protocol that advances the light-cycle by 8h every 2 days to disrupt circadian rhythms.

TL;DR: Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD) as discussed by the authors , a virtual symposium focused on connecting microglial transcriptional states to functional states, mouse models that better mimic human immunity, the potential involvement of inflammasome signaling, metabolic alterations, self-reactive T cells, gut microbes and fungal infections.

TL;DR: In this paper , the authors highlighted the relationship between COVID-19 and insomnia and how insomnia is increasing due to the pandemic, and suggested future research directions to explore the long-term health impacts of the Pandemic, therapeutic strategies and the implementation of social policies to support people with sleep difficulties.

TL;DR: In this article , the authors present the case of a 26-year-old female who suffered from acute disseminated encephalomyelitis (ADEM) four weeks after Gam-COVID-Vac administration.

TL;DR: In this paper , the authors synthesize available evidence for the association between inflammatory periodontal diseases (IPD) and major depression in relation to a broad range of biomarkers (i.e., salivary, serum, urine or gingival crevicular fluid cortisol, C reactive protein, cytokines, etc.).

TL;DR: The authors in this paper investigated the severity and chronicity of these neurologic findings over the five-year period following the COVID-19 pandemic and found that self-reported symptoms are associated with depression and anxiety.

TL;DR: In this article , the effect of anti-inflammatory medications in mental disorders was assessed using a search in Medline and the Cochrane database focusing on randomised controlled trials and systematic reviews identified 53 primary research articles, conducted in major depression, bipolar disorder, schizophrenia and somatic symptom disorders and related disorders.

TL;DR: In this paper , a 3-month trial of cognitive-behavioral and mindfulness-based stress reduction (COBMINDEX) was conducted on Crohn's disease patients, and the results showed that higher levels of distinct cytokines and cortisol at baseline correlated negatively with changes in disease activity (by Harvey-Bradshaw Index) and psychological distress.

TL;DR: In this article , a 65-year-old man developed cognitive deficits and memory impairments following his first dose of Oxford AstraZeneca vaccine (Covishield), which could be another complication to COVID-19 vaccination that physicians and neurologists need to be warned.

TL;DR: The UK public's preferences for prioritizing vaccine donations over booster shot programs suggest broad support for national policies that strike a balance between domestic containment and global philanthropy as discussed by the authors , which is consistent with the findings in the USA.

TL;DR: In this article , the authors evaluated associations between peripheral immune inflammatory markers and motor symptoms of Parkinson's disease, specifically tremor, bradykinesia, and postural and gait instability.

TL;DR: In this article , the authors described three women with pre-existing bipolar disorder presenting in catatonia, while benzodiazepines and electroconvulsive therapy failed, a dramatic resolution with corticosteroids was noted following the detection of Hashimoto's thyroiditis.

TL;DR: In this article , the authors examined the relationship between systemic inflammation and cardiometabolic genetic risk in persons with psychosis and found that persons with higher inflammation had lower BACS scores (p = 0.038) compared to those with lower inflammation.

TL;DR: In this paper , the authors identify specific associations between cognitive impairment, self-reported disruptions in memory, and psychiatric symptoms including depression, anxiety, posttraumatic stress disorder (PTSD), and perceived sleep concerns.

TL;DR: In this article , the authors outline evidence that probiotic use may attenuate stress effects on frontolimbic development, providing a novel means of improving depressive symptoms among adolescent populations.

TL;DR: The INFLAMED trial as mentioned in this paper is a double-blind randomized controlled trial with 140 patients with IMD characteristics (MDD with Inventory of Depressive Symptomatology (IDS) ≥ 26, IDS atypical, energy related symptoms ≥ 6, C-Reactive Protein (CRP) > 1 mg/L) and matching placebo for a period of 12 weeks.

TL;DR: In this paper , the role of Body Mass Index (BMI) on protein expression and signaling at the time of ELVO intervention was investigated and the protein adenosine deaminase (ADA) was found to be significantly higher in the obese population when compared to normal or overweight groups.

TL;DR: In this paper , the authors assess the associations of MS disease course and disability status with risk of serious infections, and find that the risk for serious infection was greater for progressive disease than relapsing-remitting disease (HR = 3.80; 95% CI 3.52: 4.09).

TL;DR: The α-7-nicotinic-acetylcholine receptor (α7nAChR) is involved in the inhibition of inflammatory processes, modulating the production of cytokines, suppressing dendritic cells and macrophage activity, leading to the suppression of T cells as discussed by the authors .

TL;DR: The Canadian COVID-19 Experiences Project (CCEP) as mentioned in this paper was proposed to identify social-cognitive and neurocognitive predictors of mitigation behaviors, identify optimal communication strategies to promote vaccination and mitigation behaviors and examine brain health outcomes of SARS-CoV-2 infection.

TL;DR: In this paper , the potential associations between inflammatory/antioxidant peripheral markers and presence of psychotic symptoms or severity of illness in patients affected by major psychiatric disorders were evaluated using psychometric scales.

TL;DR: For example, this article found that positive SARS-CoV-2 infection history and moderate or higher COVID-19 symptom severity are associated with significant symptoms of cognitive dysfunction and amplified delay discounting among young and middle-aged adults with no history of medically induced coma.

TL;DR: A comprehensive narrative review of studies investigating biological markers of BBB in patients with bipolar disorder, mechanisms that modulate BBB integrity, their clinical implications on patients, and key targets for future development of novel therapies is presented in this article .

TL;DR: In this article , the authors investigated cytokines levels over the course of pregnancy in women with different trajectories of depressive symptoms peripartum, and relate the levels to levels of non-pregnant controls.