B.W.J.H. Penninx

TL;DR: In this article, the authors present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD.

TL;DR: A genome-wide association study of single nucleotide polymorphisms genotyped in 1738 MDD cases and 1802 controls selected to be at low liability for MDD found 11 signals localized to a 167 kb region overlapping the gene piccolo, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain.

TL;DR: A meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN), identified 17 loci newly associated with kidney function-related traits.

TL;DR: The involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis is demonstrated and the association of SNPs in TPMRSS6 to serum iron is identified.

TL;DR: Polygenic features of major depressive disorder and two common clinical subtypes defined by symptom profiles in a large sample of adults with established diagnoses are examined, finding that subtypes are characterized by partially distinct polygenic liabilities and may represent more homogeneous phenotypes.