Showing papers in "Computers and Biomedical Research in 1989"

TL;DR: The method is applied to the study of the mechanism of human alpha 1 globin pre-mRNA splicing and a possible relationship between the structural features of the secondary structures and the order of intron excision in the pathway of precursor splicing of humanalpha 1 globins is discussed.

TL;DR: A method for the detection of the P and T waves, as well as the identification of their onset and offset boundaries in an ECG, is described in this paper, based on a recently proposed "length" transformation.

TL;DR: An algorithm for automatically locating certain characteristic anatomical points called landmarks on cephalograms (skull X-rays) used by orthodontists in diagnosis and treatment planning is presented.

TL;DR: Using the capabilities of the HELP medical information system at LDS Hospital, a Computerized Laboratory Alerting System (CLAS) was developed that monitors and alerts for the presence of life-threatening conditions in hospitalized patients which are indicated by laboratory test results.

TL;DR: The results suggest that the ventilatory support of severely ill ICU patients can be managed by a clinical information system using a blackboard control architecture.

TL;DR: The paired analysis of the cell and nuclear shape provides an exhaustive and accurate definition of the nucleoplasmic configuration.

TL;DR: The evaluation showed that CADIAG-2's initial list of diagnostic hypotheses, based on patient history, physical examination, and basic laboratory tests usually has already included the gold standard diagnosis and thus an application of CADIAg-2 at a very early stage of the diagnostic process seems achievable.

TL;DR: The potential of a computer-based approach called "knowledge management" to aid in clinical problem solving and education and the need for a "critical mass" of knowledge before such an approach will be widely utilized is explored.

TL;DR: The Hepatopix computer program helps the physician go from acomputerized clinical record directly to a computerized search of the medical literature, using a hierarchical list of current (key) topics in hepatology to offer "intelligent" searches.

TL;DR: SESAM-DIABETE is an interactive educational expert system that provides personalized advice and therapeutic recommendations for insulin-requiring diabetic patients and is currently available from their home for selected patients through the French telematic network TELETEL and is under clinical evaluation.

TL;DR: A 3D computer model that simulates electrical activity in the heart during fibrillation suggests that a dispersion of refractory states of the cell population is the cause offibrillation in this computer model.

TL;DR: A new method for aligning histological serial sections for three-dimensional reconstruction by computer is introduced, which has the capability to eliminate deformations caused by compression or stretching during sectioning by the determination of correction factors.

TL;DR: It is shown how bilaterally symmetric Laplacian-of-a-Gaussian filters can be used to recover the borders of selected lesions while remaining robust with respect to factors such as the camera point spread function and additive noise.

TL;DR: It is concluded that the automatic detection of CSR by heart rate spectral analysis during ambulatory ECG monitoring may afford a tool for the evaluation of the patients with congestive heart failure.

TL;DR: Several algorithms which recognize the signal line in the bit map and translate it into a series of numbers which are equivalent to the output of electronic analog-to-digital converters are described.

TL;DR: Spectral analysis is carried out over consecutive nonoverlapping records, and the information is displayed in the form of a compressed spectral array through parametric techniques to quantify the effect of sympatho-vagal balance on heart rate control during the 24-hr period.

TL;DR: A computer graphics program which generates spatially invariant measures of two- and three-dimensional form change using finite element methods using isoparametric scaling of finite elements, strain matrix formulation, and size/shape variable derivation is described.

TL;DR: A computer model simulating both excitation and recovery processes within a block of heart muscle tissue has been developed and implemented on different IBM PC AT compatible computers and has been used in various experiments.

TL;DR: This work presents the results of initial investigations using two dynamic programming algorithms on the Intel iPSC hypercube and the Connection Machine as well as an inexpensive, heuristically-based algorithm on the Encore Multimax.

TL;DR: The smoothing problem is formulated as a general linear model and the concurrent estimates of both V'L and Q are demonstrated and it is demonstrated how the Q estimate can be improved by utilizing more appropriate estimates of arterial carbon dioxide tension.

TL;DR: This work presents a procedure to derive simple dynamic models that capture the cardiac mechanisms which control the particular timing sequences of P and R waves characteristic of different arrhythmias in electrocardiograms.

TL;DR: A methodology that can be used to study the length of stay distribution of the patient in various states of the disease and the treatment data on cancer of cervix patients are used to illustrate its application.

TL;DR: An object-oriented and a fact-based model for the representation of genealogical information and two prototype systems are presented to explore the applicability of different inference mechanisms for various genetic problems.

TL;DR: A computer graphics system is described which reconstructs three-dimensional images from tomographic sectional data which can be exploited in planning reconstructive bone surgery and illustrates the versatility and speed of the new algorithm.

TL;DR: BUMP is a FORTRAN implementation of a modified Jonckheere-Terpstra test, proposed by Simpson and Margolin, to test nonparametrically for a dose-response curve when a downturn is possible at high doses.

TL;DR: In this article, the authors studied high-fidelity ECG waveforms displaying pronounced notches and slurs and found that the notches were found to contribute to a frequency range of 40-185 Hz whereas the slurs contributed only to the lower subrange of this frequency band below 100 Hz.

TL;DR: The purpose of this paper is to present a FORTRAN computer program allowing the computation of a kappa coefficient and to illustrate its use with examples respectively involving multiple psychiatric and multiple physical diagnoses.

TL;DR: A method for the analysis of the clinical trial design process used by experts showed that the experts rely heavily, for much of the design, on ideas presented in numerical displays in published documents.

TL;DR: A Fortran program that analyzes occupational mortality using vital statistics and census data and allows stratification on social class or other user-defined correlates of occupation such as smoking behavior is presented.