Showing papers in "Immunopharmacology in 1987"

TL;DR: The data show that prolactin can stimulate the immune system in a biphasic manner and that a reduction in the basal levels of this hormone results in an attenuated immune response.

TL;DR: Results provide further evidence for an important role of PAF in anaphylaxis and support the hypothesis that PAF is involved in asthma and other allergic diseases.

TL;DR: It is found that pretreatment of human neutrophils with ibuprofen results in an irreversible, concentration-dependent inhibition of superoxide anion generation and release of lysosomal enzymes stimulated by the synthetic peptide, N-formyl-methionyl-leucyl-phenylalanine, the complement fragment C5a, and to a lesser extent by serum opsonized zymosan.

TL;DR: The data suggests that the observed potent immunosuppressive effect of alpha- and beta-momorcharin is unlikely to be due to direct lymphocytotoxicity or due to a shift in the kinetic parameter of the immune response.

TL;DR: It is suggested that pefloxacin and ciprofloxACin could antagonize IL-1 production and release by lipopolysaccharide-stimulated monocytes, which could be interesting tools to study the production, processing, transport and release from the monocytes of IL- 1.

TL;DR: The present review concerns a relatively little explored aspect of anaphylatoxin biology; namely actions of these mediators on the circulation.

TL;DR: It is shown that thymosin fraction 5 peptides exert immunoregulatory effects on the human MLR proliferative responses in vitro.

TL;DR: DSP did not significantly suppress the responsiveness of spleen cells to succinylated concanavalin A or production of interleukin-1 or -2.0 mg/kg body weight, and responsiveness to lipopolysaccharide in vitro was not reduced.

TL;DR: Results show that beta-endorphin can selectively modulate concanavalin A-induced mitogenesis with a behavior depending on the individual characteristics of the donor's response, and that the effect is not reverted by naloxone, the specific opiate antagonist.

TL;DR: Disruption of T cell differentiation during ontogenesis is suggested which may have profound implications on the ability to resist induction and growth of neoplasias after in utero exposure to the carcinogen benzo(a)pyrene.

TL;DR: The results of inhibition and reversal by SRI 63-441 strongly implicate PAF as a pivotal mediator of hypotension and shock.

TL;DR: The results suggest that the effect of DFMO on interleukin 2 levels is mediated through polyamines, and polyamine biosynthesis may play a role in the intracellular regulation of interleucin 2 production.

TL;DR: Thymus immune suppressor function is deficient during the metamorphosis of Xenopus laevis, the South African clawed toad and endogenous corticosteroid regulation of IL-1 production to create IL-2 deficiency, thereby inhibiting T cell clonal expansion.

TL;DR: The data suggest that forskolin-induced elevations in cyclic AMP may lead to inhibition (or, more correctly, prevents the activation) of protein kinase C, presumably by inhibiting phospholipid turnover.

TL;DR: It seemed quite valuable that 15-deoxyspergualin drastically suppressed the progress of polyclonal B cell activation in both strains of autoimmune mice, which have different mechanisms leading to B cellactivation.

TL;DR: Ethanol inhibits antibody-dependent cell-mediated cytotoxicity at the programming for lysis or the lethal hit stages, consistent with a model which assumes that lysis is due to a critical number of interactions which ultimately trigger the lytic event.

TL;DR: Morphine pellet implantation in mice was demonstrated to diminish resistance to encephalomyocarditis virus infections and a clear inhibition in IFN induction appeared as a concomitant phenomenon with the syndrome of morphine dependence.

TL;DR: The results indicated the B cell from DMN-treated mice as the splenic cell type responsible for suppressed antibody-forming cell responses to dinitrophenyl-Ficoll as the primary cellular target of DMN exposure resulting in suppressed antibody responses is the B lymphocyte.

TL;DR: The results suggest that cell migration from primary lymphoid organs, particularly from the bone marrow to the spleen, is regulated by a prostaglandin-mediated system and that a prostAGlandin E2 synthesis inhibition would have a positive effect on the restoration of peripheral nucleated cells following irradiation.

TL;DR: The results suggest the existence of (R)PAF-acether-specific receptors inside the retina, which are dose-dependent and partially inhibited by simultaneous administration of Ginkgolide B (BN 52021; 2 X 10(-5) M).

TL;DR: The results obtained suggest that the drug acts on both T effector cells and lymphoblasts, and demonstrates that DXS considerably reduces lymphoblast extravasation in skin sites inflamed either by non-immune causes or by DTH.

TL;DR: The hypothesis that DMN-induced alterations in Macrophage hematopoietic differentiation/maturation are manifested in changes in macrophage function is supported.

TL;DR: The lymphocyte activation with allo A was inhibited by lactose, but not by melibiose, N-acetyl-D-glucosamine, or methyl-alpha-D -mannoside, which suggests that cell surface molecules containing beta- D-galactosyl residues are of importance in the structure of allo B receptors on the cell surface.

TL;DR: Results indicate selective effects of 2'- deoxycoformycin on immune function and suggest that subpopulations of lymphocytes differ in the degree of sensitivity to 2'-deoxyco Formycin, and provide indirect evidence that natural killer effector cells lack sensitivity to the drug.

TL;DR: It is concluded that MCA exerts an inhibitory effect on T-cell functional activity such as interleukin-2 and lymphotoxin production which correlate with a suppression of blastogenesis and natural killer cell activity.

TL;DR: Results suggest differential sensitivity in components of the host defense system to weak carcinogens in mice treated with methyl methanesulfonate and Cyclophosphamide.

TL;DR: It is found that the drug impairs the expression of both the total and high-affinity interleukin-2 (IL-2)-binding receptors on lymphoid cells in response to the mitogen phytohaemagglutinin.

TL;DR: Spleen and lymph node cells from weanling mice were more readily suppressed to concanavalin A and phytohemagglutinin than those from older mice when treated with the cannabinoid preparations, seen in the dose-response studies as well as in the studies with varying cell numbers in culture.

TL;DR: No significant differences in antibody synthesis, alpha- and gamma-interferon yield, cutaneous delayed hypersensitivity or lymphocyte blastogenic response to mitogens have been detected between erythromycin-treated subjects and controls, and the drug seems to be devoid of any adverse effects on the immune system.

TL;DR: Results indicate that cimetidine may be capable of modulating PFC development in vivo, however, this modulation depends critically upon dose, timing, and route ofcimetidine administration.