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Showing papers in "International Journal of Biochemistry in 1985"


PatentDOI
TL;DR: The invention relates to novel oligonucleotides, the process for their preparation and their biological uses as mediators of the action of interferon, which have antiviral use.

521 citations




Journal ArticleDOI
TL;DR: A broad range of substituted aromatic nitriles were attacked with a general preference being shown for those with meta substitution for the conversion of p-hydroxybenzonitrile to p-Hydroxybenzoic acid and ammonia without intermediate formation of the amide.

108 citations


Journal ArticleDOI
TL;DR: The demonstration that green plant and sea urchin egg kinases are targets for calmodulin regulation by intracellular Ca2+ links NADP+ production in these sources to the multi-level discriminatory control functions inherent to this Ca2-protein complex.

89 citations



Journal ArticleDOI
TL;DR: The abilities of Staphylococcus aureus and Streptococcus pyogenes to remove iron from mouse 59Fe hemoglobin that was either in free form or complexed with human haptoglobin, were evaluated.

65 citations



Journal ArticleDOI
TL;DR: Rat reticulocytes were incubated with rat 125I-Tf-59Fe under conditions inhibiting heme synthesis and uncoupling the oxidative phosphorylations lead to a large increase in the Fe-containing low molecular weight fraction in the cytosol.

61 citations


Journal ArticleDOI
TL;DR: In this paper, the N-terminal leader sequence of a hen methionine-containing phosphoprotein was determined for approximately seventy-seven residues from the amino terminus.

53 citations


Journal ArticleDOI
TL;DR: The experimental evidence for endocytosis in every situation is found wanting, particularly true for the hepatocyte where an alternative mechanism of iron release at the cell surface can account for all iron uptake.

Journal ArticleDOI
W. Schipfer1, B. Neophytou1, R. Trobisch1, O. Groiss1, H. Goldenberg1 
TL;DR: It is concluded that the observed reaction is brought about by transmembrane NADH-acceptor oxidoreductase with donorbinding at the inner and acceptor binding at the outer cell surface.

Journal ArticleDOI
TL;DR: The data indicate that the carbon-chains of amino acids entering the citric acid cycle in muscle, are not used for oxidation or for alanine synthesis, but are converted exclusively to glutamine.

Journal ArticleDOI
TL;DR: It is established that dietary treatment can considerably modify the fatty acid as well as the phospholipid composition of liver plasma membranes.

Journal ArticleDOI
TL;DR: The glycogen level in mouse liver was maximal during the night and decreased to the lowest level during the light period, and the peak activity of phosphorylase alpha was observedDuring the light hours and thus paralleled the decline of hepatic glycogen concentrations.

Journal ArticleDOI
TL;DR: In vitro uptake of beta-galactosidase in hepatocytes and nonparenchymal liver cells was saturable, Ca2+-dependent and it could be partly inhibited by mannose or alpha-methyl-mannoside.

Journal ArticleDOI
TL;DR: Chlorination process within phagocytosing neutrophils seems to be essential for formation of both, total HCN and that deriving from bacterial structures, which indicates that there are other substrates for HCN production.

Journal ArticleDOI
TL;DR: Concentrations of RNA in the hearts of rats fed on diets containing 27% of calories as ethanol were not altered, indicating a decrease in RNA activity for protein synthesis.

Journal ArticleDOI
TL;DR: Two acid phosphatase forms were isolated from chicken liver by gel filtration on Sephadex G-100 with similar Km- and Vmax-values, but differ in molecular weight, optimum pH, sensitivity to various inhibitors and substrate specificity.

Journal ArticleDOI
TL;DR: A purification procedure is described for Aspergillus urease, the most important step being affinity chromatography on hydroxyurea Sepharose.


Journal ArticleDOI
TL;DR: The levels of free porphyrins was low and the level of Heme-S, measured using protoporphyrin as substrate, was twice as high in symbiote-containing than in aposymbiotic C. deanei.

Journal ArticleDOI
TL;DR: Cultured chick embryo fibroblast, and rat spleen, cells rapidly and very efficiently import their own or each others cytosolic DNA complexes into their respective cytosol fractions: the material recovered from the cytOSol of recipient cells is characteristic of the presented material.

Journal ArticleDOI
TL;DR: The decline in force generating capabilities of skeletal muscle associated with prolonged, repetitive low force producing contractions does have a biochemical basis and the myofilament dissolution may be the last stage in this fatigue process and associated with only extreme conditions of muscle use.

Journal ArticleDOI
TL;DR: It is suggested that AHD-5 may be the primary enzyme for oxidizing mitochondrial acetaldehyde during ethanol oxidation in vivo, and may also exist as a monomeric form as well.


Journal ArticleDOI
TL;DR: It is taken one example of an alternative method using DABITC manually for the degradation of peptides in order to illustrate the evolution of manual degradation techniques (Chang, 1983) and takes two manual examples and two automatic procedures of degradation to underline the progress over the last decade.

Journal ArticleDOI
TL;DR: Irrespective of age, the amount of proteoglycan protein extracted from each gramme wet cartilage is the same and the amino acid composition and the proportion of the aggregable proteoglycans are also the same.

Journal ArticleDOI
TL;DR: A hitherto unknown recognition system for species specificity is postulated which protects homologous AsRTf from degradation, but directs foreign AsTf to lysosomes.

Journal ArticleDOI
TL;DR: These studies show how NMR-polarization transfer pulse sequences can be used to monitor the metabolism of 13C-ethanol in vivo, and provide a unique tool to measure in vivo concentrations of acetaldehyde.