Showing papers in "International Journal of Pharmaceutics in 1985"

TL;DR: In this article, the effects of some formulation variables on the release rates of promethazine hydrochloride from hydroxypropylmethylcellulose (HPMC) tablet matrices have been investigated.

TL;DR: In this article, the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared and particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer.

TL;DR: The micellar properties of the ABA poly(oxyethylene)-poly(oxypropylene) block copolymer Pluronic F127 have been examined in water and electrolyte solution by photon correlation spectroscopy, total intensity light scattering and viscometric techniques as discussed by the authors.

TL;DR: In this article, the effect of drug: HPMC ratio and drug particle size on drug release has also been investigated, and a straight line relationship was established between the logarithm of tablet HMMC content and the linear relationship between the HMMC ratio and the release rate.

TL;DR: In this paper, polymers of acrylic acid crosslinked (0.3% w/w) with divinyl glycol and 2,5-dimethyl-1,5hexadiene were synthesized and examined as to their utility in ocular drug delivery.

TL;DR: Investigation of the ability of Azone (1-dodecylazacycloheptan-2-one), a novel penetration enhancer, to increase the percutaneous delivery of metronidazole has been investigated, across full thickness human skin in vitro, and repeated doses of the drug indicated that the effect of AzOne on the skin remains after several days.

TL;DR: In this article, the solubility properties of β-cyclodextrin derivatives with different substituents were tested for their solubilizing properties in combination with hydrocortisone, diazepam, digitoxin and indomethacin.

TL;DR: In this paper, an attempt is made to extend the definition of the term to include cationic and non-ionic organic compounds bearing the essential structural features of Neuberg's hydropes.

TL;DR: Subsequent retention data suggested that faster process(es) than those described for insoluble particulates were contributing to the clearance of alveolar deposited liposomes.

TL;DR: In this article, the disposition of polyhexyl-2-cyanoacrylate nanoparticles in tears, aqueous humor, cornea and conjunctiva of albino rabbits was studied using radiotracer techniques.

TL;DR: In this article, an HPLC technique was used to monitor the stability of doxorubicin-HCl (DXR) in aqueous media, and the results indicated that pH 4 and 4 °C provide optimum shelf-life conditions.

TL;DR: In this paper, a modified solvent evaporation process was used to extract polylactic acid (PLA) loaded with triamcinolone acetonide (Tc)-labeled nanoparticles.

TL;DR: The thermomechanical properties and glass transition temperatures of cellulose derivatives used in the film coating of oral dosage forms have been studied using differential scanning calorimetry (DSC), differential thermal analysis (DTA), and the torsional braid pendulum as discussed by the authors.

TL;DR: In this paper, the authors showed that increasing uptake of A (0.0015 mole fraction) displaces water from the crystals (from 0.041 to 0.013 mole fraction), and increases the enthalpy of fusion, ΔH f, by 1-9%, the melting point, T m, by 0.1-0.6%, and the entropy of fusion (ΔS f, T m, and ΔS f decrease, suggesting weakening and disruption of the crystal lattice.

TL;DR: In this article, the authors studied the systemic absorption of ocularly applied pilocarpine (1.2 mg) after administration in aqueous solution, in hydroxypropylcellulose (HPC) matrix, and in a matrix of n-butyl half-ester of poly(methyl vinyl ether/maleic anhydride) (PVM/MA).

TL;DR: Coacervate yield was dependent on: the final temperature of the mixture; the time allowed for equilibration; the concentration of the gelatin solutions; and the pH and ionic strength of the media.

TL;DR: The usefulness of measuring tablet surface areas by a permeametry technique for the characterization of particle fragmentation during compaction was evaluated in this article, where eight materials (sieve fraction 212-250 μm) with varying and documented consolidation behavior were compacted at a series of pressures in the range 20-200 MPa.

TL;DR: In this article, it was shown that the degree of crystallinity depends on the fraction of crystalline material in the mixture (two-state model) and the state of disorder in the lattice (one state model).

TL;DR: In this article, microspheres intended for intra-arterial targeting of cytotoxic agents have been prepared from human serum albumin using a water-in-oil emulsion technique with chemical cross-linking of the protein.

TL;DR: In this paper, the average number of particles in such an aggregate and the variance of this number is calculated from the Poisson probability distribution function, and the ranges of concentration and ratios of droplet/particle diameters where aggregation is likely to affect significantly the aerodynamic behaviour of the drug, are outlined.

TL;DR: There appeared to be a significant vehicle effect on lymphatic absorption when monitoring the lymphatic transport of testosterone undecanoate after its oral administration in various lipid vehicles, and it did appear to be the major determinant of the bioavailability of orally administered testosterone undECanoate.

TL;DR: In this paper, the effect of propylene glycol, azone (LDA), and n -decylmethyl sulfoxide (LDB) on the permeation course of fluorouracil through the hairless mouse skin was studied.

TL;DR: In this article, the kinetics and mechanism of hydrolysis of various 1-, 3- and 1, 3-acyloxymethyl derivatives of 5-fluorouracil were studied to assess their potential as prodrugs with the aim of enhancing the delivery characteristics of the parent drug.

TL;DR: In this paper, high purity magnesium stearate and palmitate powders have been prepared at two batch sizes under different pH environments and analyzed for chemical and physical character using gas chromatography, atomic absorption, surface area estimation, scanning electron microscopy, thermal analysis, and infra-red and X-ray diffraction techniques.

TL;DR: Spreading of the solution was highly variable; the preparation reaching the ascending colon in some subjects but not dispersing beyond the sigmoid colon in others, and the distributions achieved were unrelated to bowel habit.

TL;DR: In this article, the authors showed that β-CyD · EP polymers increased the solubility and dissolution rate of phenytoin in aqueous solution and in the solid phase.

TL;DR: Sometimes antimicrobial combinations show synergy, that is their combined effects are greater than would be expected from simple addition, providing enhanced activity at lower individual preservative concentrations and its occurrence will form the basis of this review.

TL;DR: In this paper, the phagocytosis of lipid emulsion droplets prepared from soybean oil and using various emulsifying agents has been studied in vitro using mouse peritoneal macrophages.

TL;DR: In this article, both fine and coarse fractions of Avicel PH 101, AVICEL PH 105, methyl cellulose and polyvinylpyrrolidone were added to compounds with poor binding properties.

TL;DR: In this article, drug release in synthetic gastric liquid has been studied by using sheets made of sodium salicylate and Eudragit, this component playing the role of a polymer matrix.