Journal ArticleDOI
Cyclodextrins and their pharmaceutical applications.
TLDR
Cyclodextrins are still regarded as novel excipients of unexplored potential and, thus, 100 years after their discovery, new cyclodextrin-based technologies are constantly being developed.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2007-02-01. It has received 1394 citations till now.read more
Citations
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Journal ArticleDOI
Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Ocular Drug Delivery
TL;DR: Current developments in the field of ophthalmic drug delivery promise a significant improvement in overcoming the challenges posed by various anterior and posterior segment diseases.
Journal ArticleDOI
Insoluble drug delivery strategies: review of recent advances and business prospects
TL;DR: A review of the recent advances in the field of insoluble drug delivery and business prospects covers the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
References
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Journal ArticleDOI
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
TL;DR: The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation
Tetsumi Irie,Kaneto Uekama +1 more
TL;DR: The objective of this review is to summarize recent findings on the safety profiles of three natural cyclodextrins (alpha, beta- and gamma-CDs) and several chemically modified CDs and their effects on cellular processes mediated by heparin binding growth factors.