Showing papers in "International Orthopaedics in 2015"

Evidence showing the relationship between sagittal balance and clinical outcomes in surgical treatment of degenerative spinal diseases: a literature review

Abstract: The measure of radiographic pelvic and spinal parameters for sagittal balance analysis has gained importance in reconstructive surgery of the spine and particularly in degenerative spinal diseases (DSD). Fusion in the lumbar spine may result in loss of lumbar lordosis (LL), with possible compensatory mechanisms: decreased sacral slope (SS), increased pelvic tilt (PT) and decreased thoracic kyphosis (TK). An increase in PT after surgery is correlated with postoperative back pain. A decreased SS and/or abnormal sagittal vertical axis (SVA) after fusion have a higher risk of adjacent segment degeneration. High pelvic incidence (PI) increases the risk of sagittal imbalance after spine fusion and is a predictive factor for degenerative spondylolisthesis. Restoration of a normal PT after surgery is correlated with good clinical outcome. Therefore, there is a need for comparative prospective studies that include pre- and postoperative spinopelvic parameters and compare complication rate, degree of disability, pain and quality of life.

Incidence and predisposing factors of periprosthetic proximal femoral fractures: a literature review

Abstract: Purpose The purpose of this review article was to investigate the incidence and predisposing factors for periprosthetic proximal femoral fractures (PFF) following total hip arthroplasty

Does varus alignment adversely affect implant survival and function six years after kinematically aligned total knee arthroplasty

Abstract: We report the six year implant survivorship, tibial component alignment and knee and limb function measured by the Oxford Knee Score and Western Ontario and McMaster Universities Osteoarthritis Index ((WOMAC) score after kinematically aligned total knee arthroplasty (TKA) and tested the hypothesis that varus alignment of the tibial component, knee, or limb does not adversely affect implant survival and function. We prospectively followed 214 consecutive patients (219 knees) treated with a kinematically aligned TKA in 2007. Kaplan–Meier survival analysis and revision rate per 100 component years determined implant failure. The Oxford Knee Score (0 worst, 48 best) and WOMAC score (0 worst, 100 best) were used to measure function. We categorised tibial component alignment as in-range (≤ 0°) or varus (>0°), knee alignment as in-range (between -2.5° and -7.4°), varus (>-2.5°), or valgus ( 3°) or valgus (<-3°). At a mean of 6.3 years (range, 5.8–7.2), implant survivorship was 97.5 % and revision-rate per 100 component years 0.40. Three implants had been revised (deep infection one, loose tibial component one and patella instability [1); two loose patella components were pending revision and considered failures. The average Oxford Knee Score was 43 and WOMAC 91. Function of tibial components (80 %), knees (31 %) and limbs (7 %) that were aligned in varus was similar to patients aligned in-range. At a mean of 6.3 years after kinematically aligned TKA, varus alignment of the tibial component, knee and limb did not adversely affect implant survival or function, which supports the consideration of kinematic alignment as an alternative to mechanical alignment for performing primary TKA. Level of evidence, III; therapeutic study.

Effect of humeral stem design on humeral position and range of motion in reverse shoulder arthroplasty

Abstract: The impacts of humeral offset and stem design after reverse shoulder arthroplasty (RSA) have not been well-studied, particularly with regard to newer stems which have a lower humeral inclination. The purpose of this study was to analyze the effect of different humeral stem designs on range of motion and humeral position following RSA. Using a three-dimensional computer model of RSA, a traditional inlay Grammont stem was compared to a short curved onlay stem with different inclinations (155°, 145°, 135°) and offset (lateralised vs medialised). Humeral offset, the acromiohumeral distance (AHD), and range of motion were evaluated for each configuration. Altering stem design led to a nearly 7-mm change in humeral offset and 4 mm in the AHD. Different inclinations of the onlay stems had little influence on humeral offset and larger influence on decreasing the AHD. There was a 10° decrease in abduction and a 5° increase in adduction between an inlay Grammont design and an onlay design with the same inclination. Compared to the 155° model, the 135° model improved adduction by 28°, extension by 24° and external rotation of the elbow at the side by 15°, but led to a decrease in abduction of 9°. When the tray was placed medially, on the 145° model, a 9° loss of abduction was observed. With varus inclination prostheses (135° and 145°), elevation remains unchanged, abduction slightly decreases, but a dramatic improvement in adduction, extension and external rotation with the elbow at the side are observed.

Massive rotator cuff tears: definition and treatment

Abstract: The aim of this review is to summarise tear pattern classification and management options for massive rotator cuff tears (MRCT), as well as to propose a treatment paradigm for patients with a MRCT. Data from 70 significant papers were reviewed in order to define the character of reparability and the possibility of alternative techniques in the management of MRCT. Massive rotator cuff tears (MRCT) include a wide panoply of lesions in terms of tear pattern, functional impairment, and reparability. Pre-operative evaluation is critical to successful treatment. With the advancement of medical technology, arthroscopy has become a frequently used method of treatment, even in cases of pseudoparalytic shoulders. Tendon transfer is limited to young patients with an irreparable MRCT and loss of active rotation. Arthroplasty can be considered for the treatment of a MRCT with associated arthritis. There is insufficient evidence to establish an evidence-based treatment algorithm for MRCTs. Treatment is based on patient factors and associated pathology, and includes personal experience and data from case series.

Combined supracondylar femoral derotation osteotomy and patellofemoral ligament reconstruction for recurrent patellar dislocation and severe femoral anteversion syndrome: surgical technique and clinical outcome.

Abstract: Severly increased femoral anteversion is an important risk factor for patellofemoral instability. Recurrent dislocations cause a traumatic disruption of the medial patellofemoral ligament. Therefore a procedure that combines femoral derotation osteotomy and patellofemoral ligament reconstruction should be considered for patients with severely increased femoral anteversion. The aim of the study was to evaluate the subjective and objective outcomes after combined femoral derotation osteotomy and anatomical reconstruction of the MPFL. 12 consecutive patients (12 knees) with patellofemoral instability and severely increased femoral anteversion underwent combined femoral derotation osteotomy and anatomical reconstruction of the MPFL. Preoperative radiographic examination included AP and lateral views to assess patella alta. MRI was performed to evaluate trochlear dysplasia and tibial tubercle-trochlear groove (TT-TG) distance. Additionally, MRI assessment of the rotational profile was performed. Evaluation included evaluation of cartilage injuries, preoperative and postoperative physical examination, visual analog scale (VAS), Kujala score, International Knee Documentation Committee score (IKDC), Activity Rating Scale (ARS) and Tegner activity score. The average age at the time of operation was 18.2 years (range, 15–26 years). The average follow-up after operation was 16.4 months postoperatively (range, 12–28 months). No recurrent dislocation occurred. The results showed a significant improvement of the Kujala score, IKDC score and VAS (p < 0.01). The activity level according to the Tegner activity score and ARS did not show statistically significant changes (p = 0.75; p = 1.0). Combined anatomical reconstruction of the MPFL and femoral derotation osteotomy resulted in significant improvement of knee function and good patient satisfaction in young patients with severely increased femoral anteversion. No re-dislocation of the patella occured.

Consensus for physiotherapy for shoulder pain

Abstract: Shoulder pain is a common disorder. Despite growing evidence of the importance of physiotherapy, in particular active exercise therapy, little data is available to guide treatment. The aim of this project was to contribute to the development of an internationally accepted assessment and treatment algorithm for patients with shoulder pain. Nine physiotherapists with expertise in the treatment of shoulder dysfunction met in Sweden 2012 to begin the process of developing a treatment algorithm. A questionnaire was completed prior to the meeting to guide discussions. Virtual conferences were thereafter the platform to reach consensus. Consensus was achieved on a clinical reasoning algorithm to guide the assessment and treatment for patients presenting with local shoulder pain, without significant passive range of motion deficits and no symptoms or signs of instability. The algorithm emphasises that physiotherapy treatment decisions should be based on physical assessment findings and not structural pathology, that active exercises should be the primary treatment approach, and that regular re-assessment is performed to ensure that all clinical features contributing to the presenting shoulder pain are addressed. Consensus was also achieved on a set of guiding principles for implementing exercise therapy for shoulder pain, namely, a limited number of exercises, performed with appropriate scapulo-humeral coordination and humeral head alignment, in a graduated manner without provoking the presenting shoulder pain. The assessment and treatment algorithm presented could contribute to a more formal, extensive process aimed at achieving international agreement on an algorithm to guide physiotherapy treatment for shoulder pain.

Subsartorial adductor canal vs femoral nerve block for analgesia after total knee replacement

Abstract: Providing effective analgesia for total knee arthroplasty (TKA) patients remains challenging. Femoral nerve block (FNB) offers targeted pain control; however, its effect on motor function, related fall risk and impact on rehabilitation has been the source of controversy. Adductor canal block (ACB) potentially spares motor fibres of the femoral nerve, but the comparative effect of the two approaches has not yet been well defined due to considerable variability in pain perception. Our study compares both single-shot FNB and ACB, side to side, in the same patients undergoing bilateral TKA. Sixty patients scheduled for bilateral TKA were randomised to receive ultrasound-guided FNB on one leg and ACB on the other, in addition to combined spinal epidural anaesthesia. The primary outcome was comparative postoperative pain in either extremity at six to eight, 24 and 48 hours postoperatively. Secondary comparative outcomes included motor strength (manually and via dynamometer), physical therapy milestones and patient satisfaction. While pain levels were lowest at six to eight hours postoperatively and increased thereafter (P < 0.001), no significant differences were seen between extremities at any time point with regard to pain in the quantitative comparison using visual analogue scale (VAS) scores (P = 0.4154), motor strength (P = 0.7548), physical therapy milestones or patient satisfaction. However, in the qualitative comparison, a significant proportion of patients reported the leg receiving ACB to be more painful than that receiving FNB at 24 h [50.9 % (n = 30) vs 25.42 % (n = 15), P = 0.0168)]. Although we could not confirm a benefit in motor function between ACB and FNB, given the equivalent analgesic potency combined with its potentially lower overall impact if neuropraxia should occur, ACB may represent an attractive alternative to FNB.

Biological aspects of segmental bone defects management

Abstract: Segmental bone defect management is among the most demanding issues in orthopaedics and there is a great medical need for establishing an appropriate treatment option. Tissue transfer, including bone autografts or free flaps, depending on the size of the bone deficiency, is currently the "gold standard" for treatment of such defects. Osteogenic cells in combination with adequate growth factors and a suitable scaffold, from the aspect of osteoinductivity, osteoconductivity and mechanical stability, are mandatory to successfully restore a bone defect as determined in the "diamond concept". Our current knowledge on this topic is limited and mostly based on retrospective studies, case reports and a few small randomised clinical trials due to the lack of large and accurately designed randomised clinical trials using novel approaches to regenerative orthopaedics. However, preclinical research on different animal models for critical size defects is abundant, showing emerging candidate cells and cytokines for defect rebridgement. In this article we provide an overview on existing clinical studies and promising preclinical experiments that utilised osteogenic cells, growth factors and biomaterials, as well as their combination for repair of segmental bone defects.

Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis

Abstract: The purpose of this study was to access the efficacy of mesenchymal stem cells (MSCs) injection in the treatment of knee osteoarthritis (OA). Studies were identified from databases (Pubmed, Embase, Cochrane Library, Biosis Previews, ClincalTrials.gov, CBMdisc) searched to December 2014 using a battery of keywords. We included randomized controlled and controlled clinical trials of people with knee OA comparing the outcomes of pain and function for those receiving MSCs injection with those receiving no MSCs injection. Two reviewers independently selected studies, extracted relevant data and assessed study quality. Data were pooled and meta-analyses were performed. Seven randomized controlled and controlled clinical trials, studying a total of 314 participants with a diagnosis of knee OA were included. Overall, MSCs injection has no significant effect on pain [weighted mean difference (WMD) (95 % confidence interval (CI)) [−1.33(−3.08, 0.41), P = 0.13], and tends to improve self-reported physical function [standardized mean difference (SMD) (CI) = 2.35(0.92, 3.77), P = 0.001] at the last follow-up. But results from two high quality trials (94 patients) show a positive effect of MSCs injection on pain [WMD(CI) = −0.49 (−0.79, −0.19), P = 0.001]. Heterogeneity observed between studies regarding the effect of MSCs injection on pain and function was explained by the difference of follow-up time, outcome measures, control group, the source and dose of MSCs. The quality of evidence supporting these effect estimates was rated as low. MSCs injection could be potentially efficacious for decreasing pain and may improve physical function in patients with knee OA. The findings of this review should be confirmed using methodologically rigorous and adequately powered clinical trials.

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation.

Abstract: Osteochondral lesions of the talus (OLT) usually require surgical treatment. Regenerative techniques for hyaline cartilage restoration, like autologous chondrocytes implantation (ACI) or bone marrow derived cells transplantation (BMDCT), should be preferred. The aim of this work is comparing two clusters with OLT, treated with ACI or BMDCT. Eighty patients were treated with regenerative techniques, 40 with ACI and 40 with BMDCT. The two groups were homogenous regarding age, lesion size and depth, previous surgeries, etiology of the lesion, subchondral bone graft, final follow-up and pre-operative AOFAS score. The two procedures were performed arthroscopically. The scaffold was a hyaluronic acid membrane in all the cases, loaded with previously cultured chondrocytes (ACI) or with bone marrow concentrated cells, harvested in the same surgical session (BMDCT). All the patients were clinically and radiologically evaluated, using MRI Mocart score and T2 mapping sequence. Clinical results were similar in both groups at 48 months. No statistically significant influence was reported after evaluation of all the pre-operative parameters. The rate of return to sport activity showed slightly better results for BMDCT than ACI. MRI Mocart score was similar in both groups. MRI T2 mapping evaluation highlighted a higher presence of hyaline like values in the BMDCT group, and lower incidence of fibrocartilage as well. To date, ACI and BMDCT showed to be effective regenerative techniques for the treatment of OLT. BMDCT could be preferred over ACI for the single step procedure, patients’ discomfort and lower costs.

Evaluation of the accuracy of patient-specific cutting blocks for total knee arthroplasty: a meta-analysis

Abstract: Because published studies on the accuracy achieved with patient-specific guides during total knee arthroplasty (TKA) contradict each other, this systematic review and meta-analysis sought to compare radiological TKA outcomes when patient-specific cutting blocks (PSCB) were used to the outcomes when standard manual instrumentation was used. The meta-analysis was implemented according to PRISMA Statement Criteria. The primary endpoint was the hip-knee-ankle (HKA) angle, which represents the leg’s mechanical axis. The accuracy of component placement in the coronal and sagittal planes, and the accuracy of femoral component rotation were also compiled. After testing for publication bias and heterogeneity across studies, data were aggregated random-effects modeling when necessary. Fifteen articles were included: 916 total knee arthroplasty cases in the PSCB group and 998 in the MI group. The mechanical axis did not differ between the two groups (weighted mean difference 0.07°; 95 % CI, -0.5° to 0.65°; p = 0.8). Risk ratio analysis revealed no protective effect of using PSCB relative to the appearance of HKA angle outliers (RR = 0.88; 95 % CI, 0.68–1.13; p = 0.3). There was a trend towards a protective effect with PSCB for the risk of femoral component outliers, but the opposite was observed for the tibial component. The implantation procedure was stopped in 30 cases because the surgeon-authors found excessive discrepancies between the intra-operative observations and the pre-operative plan. This meta-analysis found no evidence that using patient-specific cutting blocks provides superior accuracy to using manual instrumentation during TKA.

Pre-operative education prior to elective hip arthroplasty surgery improves postoperative outcome.

Abstract: Enhanced recovery programmes have improved outcomes following elective arthroplasty surgery. There are few studies assessing the role of patient education. We therefore assessed the outcomes for patients treated at our unit. In our enhanced recovery programme, all patients are offered the chance to attend a pre-operative education class. Not all patients attend, thus allowing comparison of outcomes using our prospectively collected database. Between April 2009 and March 2013, 318 patients underwent elective total hip replacement (THR): 233 attended the class, and 85 did not. Patients attending had a significantly reduced length of stay when compared with nonattenders (3.53 vs 4.27 days, p = 0.046). This produced cost savings of >£10,000 per year. Our analysis demonstrates that preoperative education produces significantly shorter lengths of stay and cost savings. There are also effects on mobilisation and outcome scores. Patients should therefore be encouraged to attend these classes.

A nationwide analysis of risk factors for in-hospital myocardial infarction after total joint arthroplasty.

Abstract: Despite acute myocardial infarction (AMI) being a feared medical complication and currently a major cause of death after total hip and knee arthroplasty (THA/TKA), little is known about its peri-operative associated factors. Data for this retrospective cohort study were extracted from the Nationwide Inpatient Sample for 2008–2011. Multivariate logistic regression modeling was performed to determine peri-operative factors associated with the development of inpatient AMI following THA/TKA. An estimated 3,096,791 procedures were identified. Perioperative AMI rates were 0.25 % for THA and 0.18 % for TKA. Patients with AMI had significantly greater comorbidity burden, higher peri-operative mortality rates, longer length of hospital stay and increased complication rates. Independent risk factors for the development of AMI comprised advance age, male gender [odds ratio (OR) 1.4, 95 % confidence interval (CI) 1.4–1.5], THA surgery (OR 1.3, 95 % CI 1.3–1.4), low household income (OR 1.3, 95 % CI 1.2–1.4), history of cardiac disease (coronary artery disease: OR 4.9, 95 % CI 4.6–5.2; congestive heart failure: OR 2.6, 95 % CI 2.4–2.8; valvular disease: OR 1.2, 95 % CI 1.1–1.3), diabetes (OR 1.1, 95 % CI 1.1–1.2), pulmonary circulation disorders (OR 1.4, 95 % CI 1.2–1.6), cerebrovascular disease (OR 2.3, 95 % CI 2.0–2.6), peripheral vascular disorders (OR 1.5, 95 % CI 1.4–1.7), coagulopathy (OR 1.4, 95 % CI 1.2–1.5), AIDS/HIV infection (OR 7.9, 95 % CI 4.5–13.9), deficiency anaemia (OR 1.4, 95 % CI 1.3–1.5), fluid and electrolyte disorders (OR 1.9, 95 % CI 1.8–2.0) and the occurrence of concomitant postoperative complications. Our findings can be used to better identify patients at high risk of AMI and to develop strategies aimed at diminishing its incidence, which could in turn translate to improved hospital efficiency and quality of care.

Management of periprosthetic femoral fractures following total hip arthroplasty: a review.

Abstract: As the number of total hip arthroplasties (THAs) is increasing, the expected number of periprosthetic femur fractures is also expected to increase. As such, a thorough grasp of the evaluation and management of patients with periprosthetic femur fractures is imperative, and discussed in this review. This review discusses the epidemiology, classification, and management of periprosthetic femur fractures in an evidence-based fashion. Periprosthetic fracture management starts with assessing stem stability and bone quality. Well-fixed stems require fracture fixation without stem revision, while loose stems require revision THA. Periprosthetic femoral fractures after primary total hip arthroplasty are a complex and clinically challenging issue. The treatment must be based on the fracture, the prosthesis, and the patient (Table 1). The Vancouver classification is not only helpful in classifying the fractures, but also in guiding the treatment. In general, well-fixed stems require open reduction and internal fixation, whereas loose stems require revision arthroplasty.

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration.

Abstract: The use of stem cells in regenerative medicine offers hope to treat numerous orthopaedic disorders, including articular cartilage defects. Although much research has been carried out on chondrogenesis, this complicated process is still not well understood and much more research is needed. The present review provides an overview of the stages of chondrogenesis and describes the effects of various growth factors, which act during the multiple steps involved in stem cell-directed differentiation towards chondrocytes. The current literature on stem cell-directed chondrogenesis, in particular the role of members of the transforming growth factor-β (TGF-β) superfamily—TGF-βs, bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs)—is reviewed and discussed. Numerous studies have reported the chondrogenic potential of both adult- and embryonic-like stem cells and the role of growth factors in programming differentiation of these cells towards chondrocytes. Mesenchymal stem cells (MSCs) are adult multipotent stem cells, whereas induced pluripotent stem cells (iPSC) are reprogrammed pluripotent cells. Although better understanding of the processes involved in the development of cartilage tissues is necessary, both cell types may be of value in the clinical treatment of cartilage injuries or osteoarthritic cartilage lesions. MSCs and iPSCs both present unique characteristics. However, at present, it is still unclear which cell type is most suitable in the treatment of cartilage injuries.

Vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fracture: a meta-analysis of prospective comparative studies

Abstract: Purpose The goal of this article is to evaluate the efficacy and the safety of the percutaneous vertebroplasty (PVP) versus percutaneous kyphoplasty (PKP) in dealing with the osteoporotic vertebral compression fracture (OVCF).

Supracondylar humeral fractures in children: current concepts for management and prognosis

Abstract: Supracondylar humeral fractures are the most common elbow fractures in children and represent 3 % of all paediatric fractures. The most common cause is a fall onto an outstretched hand with the elbow in extension, resulting in an extension-type fracture (97-99 % of cases). Currently, the Gartland classification is used, which has treatment implications. Diagnosis is based on plain radiographs, but accurate imaging could be limited due to patient pain. Based on fracture type, the definitive treatment could be either non-operative (type I) or operative (type III/IV); however, when handling type II fractures controversy remains. Neither pin configuration have shown higher efficacy over the other. Complications are ~1 %, the most common being pin migration, with compartment syndrome as the most devastating. Overall, functional outcomes are good, and physical therapy does not appear to be necessary.

Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes

Abstract: Purpose Clinical studies in diabetic patients have demonstrated that there is a high incidence of complications in distal tibia and ankle fracture treatments. One strategy to mitigate issues with wound healing and infection in diabetic patients is to use a percutaneous technique in which autologous, bone marrow-derived, concentrated cells are injected at the site of non-unions.

A comparative study between multiple cannulated screws and dynamic hip screw for fixation of femoral neck fracture in adults

Abstract: In younger adults with fractures of the femoral neck, anatomic reduction is compulsory and maintaining the reduction is crucial. Both cannulated screws and dynamic hip screw (DHS) have the capacity of compression in the fracture site but the strength for keeping reduction is not the same. The aim of this study was to compare the results with fixations of the femoral neck fractures with cannulated screws versus dynamic hip screw. This is a randomized clinical trial study on 58 cases with a minimum of one year follow-up. Leg length discrepancy, Harris Hip Score, infection, avascular necrosis of femoral head, and union of the fracture site were evaluated. There were two failures in the first trimester in the cannulated screw group and three more failures in the second and third trimesters in this group. In the DHS group, there was no reduction and fixation failure in the follow-up period. There was no fixation failure (0 %) in Group B (DHS) but there were five fixation failures (18 %) in Group A (screw), and there is significant difference between the groups (p < 0.001). The rate of avascular necrosis was the same in both groups. It seems to us that in our practice the fixation of femoral neck fracture in young adults with the DHS is a better option compared with the osteosynthsis with multiple cannulated screws.

Mechanical complications with one hundred and thirty eight (antibiotic-laden) cement spacers in the treatment of periprosthetic infection after total hip arthroplasty

Abstract: Periprosthetic infection after total hip arthroplasty is a devastating complication. A two-stage protocol with the temporary insertion of an antibiotic-laden cement spacer is the gold standard treatment for chronic infections (Clinics (Sao Paulo) 62:99–108, 2007; Clin Orthop Relat Res 427:37–46, 2004; J Arthroplast 14:175–181, 1999; Clin Orthop Relat Res 467:1848–1858, 2009; J Arthroplast 20:874–879, 2005; J Arthroplast 24: 607–613, 2009; Clin Orthop Relat Res 469:1009–1015, 2011; Hip Int 20:26–33, 2010; J Arthroplast 24:1051–1060, 2009; J Bone Joint Surg Br 91:44–51, 2009). Some authors, however (Int J Med Sci 6(5):265–73, 2009), report mechanical complication rates with spacers in excess of 50 %.Therefore, the aim of this study is to determine (1) the mechanical complications associated with enclosed articulating partial load-bearing spacers when treating periprosthetic hip infections and (2) possible factors of influence. Between 2000 and 2011, 138 patients received an antibiotic-laden cement spacer as part of a two-stage protocol. The overall frequency of complications (spacer fracture, dislocation, femoral fracture with enclosed spacer, spacer fracture with dislocation, protusion into the pelvis) was recorded. Potential influencing factors (‘mould spacer’ vs. handmade spacer, Steinmann pins as an endoskeleton, addition of vancomycin into the spacer) were analysed. The mean age at the time of the first stage operation was 69.3 ± 10.5 years. Overall, 27 of 138 patients suffered one of the above-mentioned complications (19.6 %). Spacer fracture occurred in 12 cases (8.7 %) and dislocation in another 12 (8.7 %). There was also one periprosthetic femoral fracture with a spacer in situ, one dislocation with a simultaneous spacer fracture, and one protrusion into the pelvis (0.7 % each). Our data revealed an overall complication rate of 13.2 % with a mould spacer enclosing a Steinman pin. The mechanical complication rate of over 50 % reported by some authors cannot be confirmed. As a consequence, we recommend using a mould spacer with an enclosed Steinman pin as an endoskeleton to minimize the complication rate.

Return to work and sporting activities after high tibial osteotomy

Abstract: Purpose High tibial osteotomy (HTO) is a commonly used treatment to correct varus malalignment of the knee. The purpose of this study was, first, to determine, whether HTO allows return to pre-operative work, depending on the amount of work load. Second, the restoration of sports ability and a difference in sports activities pre- to postoperative should be analyzed.

Two-stage revision of prosthetic hip joint infections using antibiotic-loaded cement spacers: When is the best time to perform the second stage?

Abstract: Aim Managing periprosthetic joint infections remains a challenging task, and adequate treatment strategies seem to be mandatory to avoid irreversible damage of the affected joint and/or systemic complications. Two-stage revision arthroplasty includes removing all implants and subsequent implantation of an antibiotic-loaded cement spacer, followed by revision arthroplasty as the second stage. Although this procedure is well described in the literature, results remain unpredictable due to various clinical findings and the absence of prospective randomised trials. We analysed (1) mortality and (2) reinfection rates in a series of patients who underwent two-stage revision surgery for periprosthetic hip joint infections with antibiotic-augmented joint spacers. We maintained a special focus on the spacer retention period and its influence on outcome in order to determine the best time for second-stage surgery.

Meniscal scaffolds: results and indications. A systematic literature review

Abstract: Purpose The aim of this systematic review was to document the available clinical evidence to support meniscal scaffold implantation, analysing results and indications for the treatment of meniscal loss.

A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis

Abstract: Purpose Chronic tendinopathy of lateral epicondyle of the humerus, commonly known as “tennis elbow” is one of the most frequent tendinopathies caused by recurrent overload of the muscle origins. The aim of the study was to assess the effectiveness of treating lateral epicondylitis (LE) with autologous conditioned plasma (ACP) and betamethasone injections, and to compare these methods over the course of a one year follow-up.

Clinical outcome and return to work following single-stage combined autologous chondrocyte implantation and high tibial osteotomy

Abstract: Purpose Concomitant unloading procedures, such as high tibial osteotomy (HTO), are increasingly recognized as an important part of cartilage repair. This study presents survival rate, functional outcome, complication rate, and return to work following combined single-stage autologous chondrocyte implantation (ACI) and HTO.

Complications of radial head prostheses

Abstract: Radial head prostheses are indicated for treatment of complex radial head fractures not amenable for fixation. After the initial experience with silastic implants, metallic or pyrocarbon arthroplasty have been used for 20 years. Little is known about complications related to these implants. Main complications are related to loosening whether they are cemented or not cemented. Hypotheses have been proposed like inadequate stem design, insufficient cement technique, stress shielding, and foreign body reactions secondary to polyethylene wear. Pain and stiffness are other common complications often related to oversized radial head component or overstuffing of the joint with excessive lengthening of the radius. Instability can be another complication in the context of more complex trauma with lateral collateral ligament complex lesion and coronoid fracture. Fixation of the coronoid fracture, reinsertion of the lateral collateral ligament complex, and the use of monobloc radial head prosthesis are recommended to stabilize the joint. Finally, osteoarthritis is common with follow-up.

Uncemented versus cemented humeral stem fixation in reverse shoulder arthroplasty.

Abstract: This study compares the radiographic and functional outcomes of uncemented and cemented humeral fixation in reverse total shoulder arthroplasty (RTSA). A prospective research database was reviewed for RTSA patients from 2007 to 2010. Inclusion criteria were primary RTSA from one manufacturer (Exactech Equinoxe®) with a grit-blasted metaphyseal humeral stem and two year minimum follow-up. Exclusion criteria included shoulder arthroplasty for fractures, fracture sequelae or inflammatory arthropathy. Radiographic and functional outcomes were compared between the uncemented and cemented groups. A total of 97 patients (58 women, 39 men) with 100 RTSAs met the inclusion criteria. Radiographic and clinical two year follow-up was available in 80 % (51 RTSAs) of the uncemented group and 89 % (32 RTSAs) of the cemented group (mean follow-up 3.5 years). Average age at surgery was 72 years. Both groups showed significant improvements in the 12-item Simple Shoulder Test (SST-12), 12-item Short Form (SF-12), Shoulder Pain and Disability Index 130 (SPADI-130), American Society of Shoulder and Elbow Surgeons (ASES) score and normalised Constant scores. One humeral loosening was seen in each group (2 % uncemented, 3 % cemented). Both groups’ overall component revision rate was 6 % (one in each group relating to humeral component failure). There were no significant differences in complication rates, change in functional scores and range of motion improvement. Humeral component press-fitting in RTSA provides similar outcomes as cementation at a minimum two year follow-up.

Orthopaedic surgery in natural disaster and conflict settings: how can quality care be ensured?

Abstract: Medecins sans Frontieres (MSF) is one of the main providers of orthopaedic surgery in natural disaster and conflict settings and strictly imposes a minimum set of context-specific standards before any surgery can be performed. Based on MSF’s experience of performing orthopaedic surgery in a number of such settings, we describe: (a) whether it was possible to implement the minimum standards for one of the more rigorous orthopaedic procedures—internal fixation—and when possible, the time frame, (b) the volume and type of interventions performed and (c) the intra-operative mortality rates and postoperative infection rates. We conducted a retrospective review of routine programme data collected between 2007 and 2014 from three MSF emergency surgical interventions in Haiti (following the 2010 earthquake) and three ongoing MSF projects in Kunduz (Afghanistan), Masisi (Democratic Republic of the Congo) and Tabarre (Haiti). The minimum standards for internal fixation were achieved in one emergency intervention site in Haiti, and in Kunduz and Tabarre, taking up to 18 months to implement in Kunduz. All sites achieved the minimum standards to perform amputations, reductions and external fixations, with a total of 9,409 orthopaedic procedures performed during the study period. Intraoperative mortality rates ranged from 0.6 to 1.9 % and postoperative infection rates from 2.4 to 3.5 %. In settings affected by natural disaster or conflict, a high volume and wide repertoire of orthopaedic surgical procedures can be performed with good outcomes when minimum standards are in place. More demanding procedures like internal fixation may not always be feasible.

Patient-specific implants for lateral unicompartmental knee arthroplasty

Abstract: The lateral compartment of the knee is biomechanically and anatomically different from the medial compartment. Most commercially available unicompartmental implants are not designed specifically for the lateral compartment. Patient-specific custom-made unicompartmental knee arthroplasty (UKA) are designed to provide optimal fit on both femoral and tibial surfaces. This study aimed to determine if the use of patient-specific lateral unicompartmental implants provide better bone coverage than standard, off-the-shelf commercially available unicompartmental implants in lateral unicompartmental knee arthroplasties. As a secondary question, we wished to determine if patient-specific unicompartmental implants provide good clinical outcomes in surgical treatment of lateral unicompartmental osteoarthritis. We prospectively evaluated 33 patients who underwent lateral unicompartmental arthroplasty using patient-specific implants and instrumentation with a minimum of 24 months of follow-up. We analysed bone coverage observed in plain radiographs in 33 patient-specific lateral unicompartmental arthroplasties and compared to 20 lateral unicompartmental arthroplasties performed with commercially-available, standard off-the-shelf unicondylar implants. The mean tibial implant lateral coverage mismatch in the patient-specific implant group was 1.0 mm (S.D. 1.2, range 0–5.7 mm ) versus 3.3 mm (S.D. 2.43, range 0.4–7.8 mm) in the conventional implant group (p < 0.01). In the patient specific cohort, pre-operative limb alignment was 3.3 (valgus) and post-operative limb alignment was −0.9 (varus). The Knee Society score improved from 48 (S.D. 16.2) to 95 (S.D. 7.6). Survivorship in the patient-specific implant group was 97% at an average follow up of 37 months, versus 85% at a follow-up period of 32 months for the standard implant group. Patient-specific lateral unicompartmental knee replacements demonstrated better tibial coverage and provide excellent short-term clinical and radiological results as compared to a standard lateral UKA.