Showing papers in "Joint Bone Spine in 2020"

TL;DR: The risk of COVID-19 in rheumatic patients under biologic agents or small molecules does not appear different from that observed in the general population, and patients should be informed to safely proceed with their treatment and follow the rules for self-protection to COVID

TL;DR: In this article, the authors proposed tocilizumab, a humanized monoclonal antibody anti-interleukin-6 receptor (anti-IL-6R) to turn off the cytokine storm.

TL;DR: This review summarizes the predictors of radiographic progression in patients with axial spondyloarthritis as well as the current evidence on the effect of available treatments on structural progression.

TL;DR: Though the prognosis of SSc remains poor, an optimized stratification of patients along with the recent and ongoing advances in therapies could greatly impact the natural course of the disease in the near future.

TL;DR: A meta-analysis revealed an increased risk of RA in patients with periodontitis compared to healthy controls and when stratified by disease type, there was a higher risk between incident RA andperiodontitis.

TL;DR: One new focus is on the importance of microbiological documentation (blood cultures and joint aspiration) before starting antibiotic treatment, looking for differential diagnoses (microcrystal detection), the relevance of a joint ultrasound to guide aspiration, and the indication to perform a reference X-ray.

TL;DR: These are the first recommendations of the SFR on the pharmacological treatment of knee osteoarthritis and five general principles were established: need to combine pharmacological and non-pharmacological treatments, need to regularly re-assess the treatments, and need to talk about arthroplasty if medical treatment fails.

TL;DR: Recommendations aim to provide simple and clear guidance for the management of ULT in France and emphasize the importance of patient education.

TL;DR: Metabolomics provides important new opportunities for further research in rheumatoid arthritis and is expected to elucidate the pathogenesis of rheumatic arthritis that has not been fully understood before.

TL;DR: Severe SAMSs with major weakness and marked CK elevation should suggest the rare eventuality of necrotizing autoimmune myopathy and prompt an anti-HMGCR antibody assay and muscle biopsy to ensure that immunosuppressant therapy is started rapidly if needed.

TL;DR: The expanding spectrum of rheumatologic and autoimmune conditions for which JAK inhibition may represent new avenues in clinical practice is described, including arthritis, psoriatic arthritis, and ulcerative rectocolitis.

TL;DR: Current available data on managing patients with rheumatic diseases during the COVID-19 pandemic are reassuring and support continuing or initiating symptomatic as well as specific treatments of these diseases, the main target of their management remaining their appropriate control, even during this pandemic.

TL;DR: PsA is characterized by an increase in cardiovascular morbidity in relation with insulin resistance, and current treatments seem to improve this risk with a decrease in cardiovascular mortality in comparison with patients with plaque psoriasis but this requires confirmation in larger prospective studies.

TL;DR: A meta-analysis showed an increased risk of hip fracture in patients with BDZs compared with non-users, and Physicians should be aware of the unwanted consequence of BDzs when they will prescribe BDZS for their patients especially elderly patients.

TL;DR: It is demonstrated that bone-resorptive volume in post-collapse ONFH was significantly associated with the disease stage, which was more widespread in the anterior portion of the femoral head than in the posterior portion.

TL;DR: Burosumab (KRN23) is a fully human monoclonal antibody against fibroblast growth factor-23 that was recently approved for the treatment of X-linked hypophosphatemia and resulted in improvement in pain symptoms and mobility.

TL;DR: Future studies should examine modifiable mediators of differences in healthcare utilization by insurance payer, and income to target them to reduce utilization.

TL;DR: Löfgren's syndrome is a well-differentiated form of sarcoidosis with persuasive different epidemiological, clinical, radiological and prognostic features.

TL;DR: This state of the art article addresses six questions revived by the recent demonstration that DNA from several mucosal bacteria could be found in numerous tissues, including Prevotella spp, either in HLA-B27 rats with or without arthritis, or control ratsWithout arthritis.

TL;DR: Treatment of GPA is based on a combination of corticosteroids and cyclophosphamide or rituximab, which allows remission to be achieved in more than 80% of cases, and Azathioprine was the most widely used maintenance treatment, but low-dose semi-annual ritUXimab maintenance infusions further decrease relapses with acceptable safety.

TL;DR: Joint Bone Spine - Sous presse, corrigees par l'auteur.

TL;DR: Inflammatory cytokines such as TNF-α, IL-1 and IL-17, are certain implicated, but not initially, and appear as a common execution pathway for a lengthy sentence following an unfortunate encounter between genetic predisposition and a harmful environment.

TL;DR: This kind of procedure should be kept in the therapeutic armament in the current setting of costly targeted systemic treatments of spondyloarthritis, however, definition of a clear position in the treatment strategy needs further well-conducted studies.

TL;DR: Infectious complications with biologics occurring in children treated for JIA are rare, and in most of the cases have a mild or moderate severity, affecting mainly the upper respiratory tract or the Ear, nose and throat system.

TL;DR: The association observed between the gen HLA-B27 and the presence of osteoporosis in Axial Spondyloarthritis patients could be of great relevance given the impact of osteoplasms in the phenotypical frame of these patients.

TL;DR: AS-qCRP performed similarly well compared to ASDAS-CRP with the absolute agreement on the disease activity category according to the ASDAS of 94% and is feasible for an immediate decision-making in clinical practice and trials aimed at treating to target.