Showing papers in "Journal of Pharmaceutical and Biomedical Analysis in 1998"

TL;DR: How to evaluate the calibration line, devise experiments to estimate precision and bias and how to determine the stability of the analyte between the time of the sample collection and the analysis of the processed sample is explained.

TL;DR: Dissolution efficiency (D.E.), the area under a dissolution curve between defined time points, and the fit factors have been compared for the characterisation of dissolution profiles, using data from three batches of a product in nine different packs stored under two conditions to conclude that D.E. offers a suitable alternative to the single point dissolution measurement for QC of immediate release products.

TL;DR: The results obtained indicated that during development and validation of LC/MS/MS based assays the potential effect of co-eluting 'unseen' endogenous species should be evaluated to ensure that sample preparation and chromatography is adequate to overcome the matrix effect problems.

TL;DR: It has been demonstrated that the WApH technique is able to deduce pKa values with high accuracy even if the absorption spectra of the reacting species are very similar, as well as those derived from pH-metric titrations.

TL;DR: In this article, a D-optimal experimental design is used to cover the 85-115% range of the target formulation which is comprised of the active component at 3.5% w/w, Microcrystalline Cellulose (Avicel PH102) at 62%, Dibasic Calcium Phosphate Anhydrous at 31.5%, Sodium Starch Glycolate (Explotab) at 2%, and 1% Magnesium Stearate.

TL;DR: These are the first reported results on human tumour tissues using this technique and the approach offers potential for the rapid classification of different types of tumour tissue.

TL;DR: This review covers applications of NMR spectroscopy in drugs analysis, in particular, methods of international pharmacopoeiae, pharmaceutics and pharmacokinetics.

TL;DR: The physical instability of proteins and peptides as well as the various analytical techniques used to study the various aspects of physical instability have been reviewed.

TL;DR: The present paper provides the principles of chemiluminescence (CL) and its powerful applications in analytical chemistry, mainly in the area of flow injection analysis, column liquid chromatographic and capillary electrophoretic separating systems, and its potential in immunoassays.

TL;DR: The HPTLC method was found to be reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime in their raw materials and their dosage forms.

TL;DR: On the basis of DSC results, ibuproxam was found to be compatible with corn starch, avicel and sodium carboxymethylcellulose, and some drug-excipient interaction was observed with polyethyleneglycol 4000, palmitic acid, stearic acid and Mg stearate.

TL;DR: This report describes a simple, rapid and reproducible method with a calibration range of 0.2-10 micrograms ml-1 voriconazole in human plasma which is more appropriate for routine clinical use than the authors previously published method.

TL;DR: It is demonstrated that in situ micromachining can be used to simultaneously fabricate millions of micrometer size, particle like structures in multiple liquid chromatography columns on a single wafer.

TL;DR: A novel spectrophotometric method based on the development of a red colour with sodium bismuthate, as a sensitive chromogenic reagent, in aqueous medium at pH 3.0 nm has successfully been applied to determination of these catecholamines in pharmaceutical preparations.

TL;DR: The use of FT-Raman spectroscopy for pharmaceutical development activities is introduced and specific examples will be shown for investigations of crystal forms (qualitative and quantitative) and crystallization studies.

TL;DR: The possibility of evaluating the content of hydrogen peroxide in several authentic matrices, such as cosmetic and pharmaceutical formulations, was studied and a preliminary check was needed to establish the best conditions to analyse these matrices.

TL;DR: A reversed-phase high-performance thin-layer chromatography method has been validated and shown to be sensitive, efficient, and reliable, and can be used as an excellent alternative to the HPLC stability testing of losartan potassium in COZAAR tablets.

TL;DR: The applicability of the gas chromatography-mass spectrometry method is illustrated by the determination of guanidinoacetate in urine, plasma and CSF of a patient affected with guanidine methyltransferase deficiency, in all body fluids of this patient, which was highly elevated.

TL;DR: SPME/LC is more sensitive than direct HPLC analysis without the SPME process and is enough to assay benzodiazepines in a human urine sample without tedious and complex analytical procedures.

TL;DR: A voltammetric method has been developed for the determination of metronidazole in dosage forms based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applying a new pretreatment.

TL;DR: A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate, imidazolidinylurea, a mixture of methyl-(III), ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and ascor byl palmitate, was studied.

TL;DR: The temperature influence on creation of a supramolecular complex in which beta-cyclodextrin is the host molecule and phenolphtalein is the guest has been studied in aqueous solution by UV-visible absorption spectroscopy and the stoichiometric ratio of investigated complex was found to be 1:1.

TL;DR: Good separations of methyl, ethyl, butyl and propyl hydroxybenzoates, and a range of ionic and neutral water soluble and insoluble compounds was achieved using a single set of separation conditions.

TL;DR: A high-performance liquid chromatography tandem mass spectromaetry-mass spectrometry (LC-MS-MS) assay was developed for the analyses of morphine, morphine glucuronides and normorphine in plasma samples from rats and was applied to a pharmacokinetic study in rats after intraperitoneal administration of morphine.

TL;DR: A rapid, simple assay procedure was developed for simultaneous analysis of aspirin (ASA) and salicylic acid (SA) in aspirin delayed-release tablet formulation by 'zero crossing' second-derivative UV spectrophotometry.

TL;DR: Solid phase micro extraction and gas chromatographic analysis was used for the analysis of several benzodiazepines in human urine and plasma and this method offers sufficient enrichment for bioanalysis after a single dose, but for low dose benzdiazepines as flunitrazepam, further sensitivity is needed.

TL;DR: A modified high performance liquid chromatography (HPLC) method for the quantification of vancomycin levels in plasma and tissues is described and was fully validated in terms of recovery, linearity, selectivity and various stability conditions.

TL;DR: Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in biological material of humans and rats following solid-phase or liquid-liquid extraction.