Showing papers in "Kidney International in 1988"

TL;DR: It is concluded that continuous CsA therapy for more than 12 months causes a chronic injury to renal microvessels that is rarely reversible and potentially progressive.

TL;DR: Results suggest that abnormal lipid metabolism may be important in the pathogenesis of FGS, although the precise mechanism remains to be defined.

TL;DR: Both the developing atherosclerotic and FSGS lesions seem to share certain postulated pathophysiologic mechanisms, including endothelial cell injury, macrophage infiltration, hyperlipoproteinemia, and hypertension, as an adjunct to increased glomerular barrier dysfunction.

TL;DR: It is concluded that SVS is a common dialysis problem that is amenable to treatment with PTA and lowering venous dialysis pressure and restoring patency to the fistula in 100%.

TL;DR: The influx of leukocytes following obstruction was paralleled by an increase in thromboxane B2 excretion by the kidney and coincided with a decrease in glomerular filtration rate (GFR), suggesting that an influx of immune cells is a prominent feature of the acute renal response to ureteral obstruction.

TL;DR: Overall, a level of baseline proteinuria of 10 g or more per 24 hours and variable blood pressure control in hypertensive patients were associated with renal progression and there was no difference between untreated and treated groups.

TL;DR: Iron chelators which underwent filtration and gained access to this free iron in the urine provided protection, whereas a chelator confined to the vascular space (dextran-conjugated deferoxamine) did not.(ABSTRACT TRUNCATED at 250 WORDS)

TL;DR: It is concluded that plasma exchange associated to chemotherapy rapidly removes large amounts of light chains, improves both renal function and long-term survival expectancies.

TL;DR: Only by considering Ce as the true end-HD urea concentration it is possible to minimize the errors arising from the application of a single pool analysis to a two pool system.

TL;DR: The increase in large pore area seen in patients with clinical nephropathy is preceded by loss of anionic charge in the glomerular basement membrane, likely due to loss of heparan sulphate-proteoglycan.

TL;DR: Of 20 patients treated with oral cyclosporine, 14 had a complete remission and the remaining six had a reduction in their proteinuria, suggesting a sustained remission of up to a year in steroid-resistant nephrotic patients.

TL;DR: It is demonstrated that cellular host defense may be impaired early in the dialysis cycle as a result of lactate mediated "stunning" of resident phagocytes, and low pH (5.3) and high sodium lactate concentration in combination are directly responsible for the suppressive effect of unused fluid and early dwell effluent on cell function.

TL;DR: Two-thirds of pediatric patients undergoing CAPD/CCPD have persistent hyperparathyroidism despite treatment with calcitriol, but aluminum can adversely affect BFR when SA exceeds 30% regardless of histologic lesion or serum parathyroid hormone level.

TL;DR: The data suggest that growth impairment in the uremic rat is partially responsive to GH, and this is not accompanied by an increase of circulating IGF I.

TL;DR: Based on patient and technique survival, CAPD would appear to be an excellent alternative to HD and may be the preferred treatment for high risk patients over the age of 66 and no risk factors were found to be significantly associated with technique survival.

TL;DR: In this paper, the authors established permanent cell lines of cloned glomerular epithelial, mesangial, and endothelial cells from a line of mice transgenic for the early region of simian virus 40 (SV40).

TL;DR: Analysis with radiotracer and high performance liquid chromatography techniques showed that intact GSH is transported intact into cells primarily of proximal tubule origin, and this transported GSH can be used to supplement endogenous synthesis and GSSG reduction to protect cells against oxidative injury.

TL;DR: The results indicate that rats have substantial capacity to tolerate prolonged severe hypoosmolality with little morbidity and mortality as long as proper attention is paid to their nutritional requirements, and provide further evidence that brain volume regulation likely represents the major adaptive mechanism that allows survival despite sustained hypoos molality.

TL;DR: Uremia increases myocardial interstitial ground substance by mechanisms independent of hypertension, and may be relevant for recent findings of diastolic heart malfunction secondary to impaired compliance in uremic patients.

TL;DR: Data show that partial correction of renal anemia results in a significant increase of both exercise capacity and maximum work.

TL;DR: Protein binding of several drugs currently used in renal failure is affected in parallel with renal function, which might affect the therapeutic effectiveness of the drugs.

TL;DR: Evidence is provided for increased cardiac pre-load, as assessed by plasma atrial natriuretic factor (ANF) and cardiac index, in hypertensive as compared to normotensive ADPKD, and hypothesized that the renal involvement of hypertensive AD PKD patients causes an impaired renal response to the observed increase in cardiac index.

TL;DR: In the presence of plasma, IL-1-inducing factors pass into the blood compartment of a dialysis system challenged with bacterial pyrogen; and in vitro MNC production ofIL-1 is enhanced in the absence of plasma.

TL;DR: It is indicated that male MWF/Ztm rats develop spontaneous proteinuria, which progressively increases with the age, and whole kidney inulin clearance and single nephron glomerular filtration rate were significantly higher in male than in female rats.

TL;DR: Observation chez un homme de 33 ans : Traitement par quinine en intraveineuse et guerison 32 jours plus tard avec un taux serique de creatinine a 1,1 mg/dl.

TL;DR: Overall, lovastatin appears to be an effective drug for the treatment of hyperlipidemia in the nephrotic syndrome.

TL;DR: The protective effects of DMTU and DFO provided marked protection even when they were stopped prior to the onset of proteinuria, implicate an important role for hydroxyl radical in PAN-induced nephrotic syndrome.