Showing papers in "Synthetic Communications in 2014"

TL;DR: In this paper, the authors summarized various methods for the synthesis of coumarins via Knoevenagel condensation, including mild, efficient, and environmentally friendly protocols with good yield and purity.

TL;DR: A review of recent developments in the synthesis over the past decade (2004-2013) is given in this article, where the 1,3,4-oxadiazole nucleus shows a broad spectrum of pharmaceutical applications.

TL;DR: The development of new synthetic approaches to the 1,4-benzodiazepine ring system and their further elaboration have provided access to a broad range of functionalized derivatives.

TL;DR: In this paper, a review summarizes the synthesis of various multispiro heterocyclic compounds by using isatin through 1,3-dipolar cycloaddition reactions and multicomponent reactions.

TL;DR: A systematic and comprehensive survey of the methods of preparation of benzofurans can be found in this article, with a focus on the synthesis of a variety of synthetically useful and novel heterocyclic systems.

TL;DR: The aim of this review is to present the most recent deeds in the field of synthetic route made for functionalized pyrazole derivatives active against cell proliferation disease.

TL;DR: An overview of the application of microwave irradiation in oxygen-containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5-10 years as mentioned in this paper.

TL;DR: In this paper, the important role of solid-phase synthesis in the synthesis of oxygen-bearing heterocycles is discussed. But, this work is limited to a single class of compounds.

TL;DR: In this article, the authors report the important role of solid phase synthesis in the synthesis of nitrogen containing six-membered ring heterocycles. But they do not consider the use of solid-phase organic synthesis in synthetic medicine.

TL;DR: An overview of the application of microwave irradiation in the synthesis of nitrogen-containing seven and higher membered heterocyclic compounds is presented in this paper, focusing on the developments in the past 5-10 years.

TL;DR: An overview of the application of microwave irradiation in sulfur-containing seven-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5-10 years as discussed by the authors.

TL;DR: An overview of the application of microwave irradiation in oxygen-containing five-membered heterocyclic compound synthesis is presented, focusing on the developments in the past 5-10 years.

TL;DR: In this paper, an efficient base catalyst for the synthesis of biologically active functionalized spirochromene derivatives via three-component reaction of isatins/acenaphthoquinone, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media is presented.

TL;DR: This review focuses on the recent developments in pyrazole along with their structure–activity relationship (SAR) for anticancer activity, particularly for antic cancer activity.

TL;DR: A comprehensive account of the synthetic utility of benzothiazole employed in the design and synthesis of different types of compounds containing fused heterocyclic rings with greater emphasis on recent literature is given in this paper.

TL;DR: An efficient, high-yielding, and rapid protocol has been developed for the synthesis of diversity-oriented 6-amino-2,4-dihydropyrano[2,3-c]pyrazol-5-carbonitriles derivatives via a four-component, one-pot cyclocondensation reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile using silica-supported tetramethylguanidine as a heterogeneous catalyst for the first time as mentioned in this paper.

TL;DR: In this article, a systematic and comprehensive survey of the method of preparation and chemical reactivity of 2-amino-3-cyanopyridines is presented, and the target compounds are important intermediates for the synthesis of a variety of synthetically useful and novel heterocyclic systems.

TL;DR: In this paper, an efficient and environmentally benign synthesis of 3-substituted or 3-4-disubstitized coumarins was accomplished via iron(III) chloride-catalyzed cascade reactions of salicylaldehydes and activated methylene compounds.

TL;DR: In this paper, a review of the applications of peroxy acids for the generation of a range of structurally diverse organic compounds is presented, focusing on the use of peroxide acids in organic synthesis.

TL;DR: In this article, the synthesis and reactions of 2-amino-3-carbethoxythiophenes as building blocks for the syntheses of poly functionalized heterocyclic compounds are described.

TL;DR: The electrochemical bromination of 4-methoxy toluene by two-phase electrolysis yields 3-bromo 4methoxyl benzyl bromide as a final product in 86% yield.

TL;DR: In this article, the synthesis of new thiopyrano[2,3-d]thiazole derivatives relevant for medicinal chemistry purposes under hetero-Diels-Alder reaction conditions was studied.

TL;DR: Water was a suitable medium for Paal-Knorr pyrrole cyclocondensation as mentioned in this paper, and an efficient, green method using water either as environmentally friendly solvent or catalyst was presented.

TL;DR: In this article, the synthesis of coumarins by hydroxyalkylation of phenols with ethyl acetoacetate (via Pechmann reaction) is attempted using magnetically separable and reusable CuFe2O4 nanoparticles in water.

TL;DR: In this article, an acetic acid-promoted, one-pot synthesis of tetrahydropyridines has been developed under metal-catalyst-free conditions via a tandem reaction.

TL;DR: In this paper, a review of the methods of synthesis and chemical reactivity of 2-pyridone and some derivatives as 2-chloro-3-nicotinonitrile is presented.

TL;DR: In this article, a solvent-free oxidative synthesis of substituted benzimidazoles, benzoxazoles and benzothiazoles from aromatic primary amines and o-phenylenediamine, o-aminophenol, and oaminothiophenol has been achieved by using Fe(NO3)3 and TEMPO (2,2,6,6-tetramethyl-1iperidinyloxyl).

TL;DR: In this article, the key concepts of solid-phase methodology and combinatorial synthesis with particular focus on the important role of solid phase synthesis in the synthesis of nitrogen-containing five-membered ring heterocycles are introduced.

TL;DR: In this article, two new organic dyes based on indigo were prepared and used as sensitizers in dye-sensitized solar cells, where indoxyl was utilized as the electron-donor and acrylic acid and cyanoacrylic acid were used as the anchor groups.

TL;DR: In this paper, the desired 1,3,4-thiadiazole compounds bearing different substituents were obtained by the cyclization of the corresponding thiosemicarbazide followed by the reaction with electrophilic reagents, such as aromatic aldehydes, isatin, phenyl isothiocyanate, and carbon disulfide.